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Development of immunoglobulin G and immunoglobulin E antibodies to cow's milk proteins and ovalbumin after a temporary neonatal exposure to hydrolyzed and whole cow's milk proteins.

Abstract

The ingestion of food antigens usually results in the induction of oral tolerance, but the clinical and immunologic consequences of brief exposure to cow's milk proteins during the neonatal period are not well-documented. The aim of this work was to study immunoglobulin (Ig)E and IgG responses to cow's milk proteins and ovalbumin after exposure during the first three days of life in infants who were otherwise exclusively breast-fed. A group of 129 infants was randomly assigned at birth to one of three feeding regimens: human milk (HM), cow's milk formula (CMF), or a casein hydrolysate formula (CHF), during the first three days of life. They were then all exclusively breast-fed for a varying period of time and followed for two years. Serum IgG and IgE antibodies to cow's milk proteins and ovalbumin (OVA) were analyzed in blood samples obtained at birth, at 4 days and at 2, 4, 8, 12 and 24 months of age. The levels of IgG antibodies to beta-lactoglobulin (IgG-BLG) and bovine serum albumin (IgG-BSA) were higher in the CMF and the HM groups than in the CHF group for up to two years. This was particularly obvious for IgG-BLG in infants who started weaning before two months. The levels of IgG antibodies to casein (IgG-CAS) were higher in the CMF group, as compared with the CHF group at 8 and 12 months. The levels of IgG antibodies to OVA were similar in all three feeding groups. The levels of IgE antibodies to CAS or OVA were similar in the three feeding groups. Exposure to cow's milk during the first three days of life stimulated IgG antibody production to cow's milk proteins and this was still obvious at 2 years of age, while feeding with a casein hydrolysate during the first three days of life was associated with low levels of IgG antibodies to cow's milk proteins.

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  • Authors+Show Affiliations

    ,

    Department of Paediatrics, Odense University Hospital, Denmark.

    , , ,

    Source

    MeSH

    Animals
    Antibody Specificity
    Bottle Feeding
    Caseins
    Cattle
    Child, Preschool
    Female
    Humans
    Hypersensitivity
    Immunoglobulin E
    Immunoglobulin G
    Infant
    Infant, Newborn
    Lactoglobulins
    Longitudinal Studies
    Male
    Milk Proteins
    Ovalbumin
    Prevalence
    Protein Hydrolysates
    Serum Albumin, Bovine
    Time Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10565560

    Citation

    Juvonen, P, et al. "Development of Immunoglobulin G and Immunoglobulin E Antibodies to Cow's Milk Proteins and Ovalbumin After a Temporary Neonatal Exposure to Hydrolyzed and Whole Cow's Milk Proteins." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 10, no. 3, 1999, pp. 191-8.
    Juvonen P, Månsson M, Kjellman NI, et al. Development of immunoglobulin G and immunoglobulin E antibodies to cow's milk proteins and ovalbumin after a temporary neonatal exposure to hydrolyzed and whole cow's milk proteins. Pediatr Allergy Immunol. 1999;10(3):191-8.
    Juvonen, P., Månsson, M., Kjellman, N. I., Björkstén, B., & Jakobsson, I. (1999). Development of immunoglobulin G and immunoglobulin E antibodies to cow's milk proteins and ovalbumin after a temporary neonatal exposure to hydrolyzed and whole cow's milk proteins. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 10(3), pp. 191-8.
    Juvonen P, et al. Development of Immunoglobulin G and Immunoglobulin E Antibodies to Cow's Milk Proteins and Ovalbumin After a Temporary Neonatal Exposure to Hydrolyzed and Whole Cow's Milk Proteins. Pediatr Allergy Immunol. 1999;10(3):191-8. PubMed PMID: 10565560.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Development of immunoglobulin G and immunoglobulin E antibodies to cow's milk proteins and ovalbumin after a temporary neonatal exposure to hydrolyzed and whole cow's milk proteins. AU - Juvonen,P, AU - Månsson,M, AU - Kjellman,N I, AU - Björkstén,B, AU - Jakobsson,I, PY - 1999/11/24/pubmed PY - 1999/11/24/medline PY - 1999/11/24/entrez SP - 191 EP - 8 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 10 IS - 3 N2 - The ingestion of food antigens usually results in the induction of oral tolerance, but the clinical and immunologic consequences of brief exposure to cow's milk proteins during the neonatal period are not well-documented. The aim of this work was to study immunoglobulin (Ig)E and IgG responses to cow's milk proteins and ovalbumin after exposure during the first three days of life in infants who were otherwise exclusively breast-fed. A group of 129 infants was randomly assigned at birth to one of three feeding regimens: human milk (HM), cow's milk formula (CMF), or a casein hydrolysate formula (CHF), during the first three days of life. They were then all exclusively breast-fed for a varying period of time and followed for two years. Serum IgG and IgE antibodies to cow's milk proteins and ovalbumin (OVA) were analyzed in blood samples obtained at birth, at 4 days and at 2, 4, 8, 12 and 24 months of age. The levels of IgG antibodies to beta-lactoglobulin (IgG-BLG) and bovine serum albumin (IgG-BSA) were higher in the CMF and the HM groups than in the CHF group for up to two years. This was particularly obvious for IgG-BLG in infants who started weaning before two months. The levels of IgG antibodies to casein (IgG-CAS) were higher in the CMF group, as compared with the CHF group at 8 and 12 months. The levels of IgG antibodies to OVA were similar in all three feeding groups. The levels of IgE antibodies to CAS or OVA were similar in the three feeding groups. Exposure to cow's milk during the first three days of life stimulated IgG antibody production to cow's milk proteins and this was still obvious at 2 years of age, while feeding with a casein hydrolysate during the first three days of life was associated with low levels of IgG antibodies to cow's milk proteins. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/10565560/Development_of_immunoglobulin_G_and_immunoglobulin_E_antibodies_to_cow's_milk_proteins_and_ovalbumin_after_a_temporary_neonatal_exposure_to_hydrolyzed_and_whole_cow's_milk_proteins_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0905-6157&date=1999&volume=10&issue=3&spage=191 DB - PRIME DP - Unbound Medicine ER -