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[Alternative nutrition and glutathione levels].
Cas Lek Cesk. 1999 Aug 30; 138(17):528-31.CL

Abstract

BACKGROUND

Low protein quality and quantity is reported to be a possible risk of alternative nutrition. Pulses contain 18-41% of methionine in relation to reference protein, moreover, its content in cereals is by one half lower. Therefore vegetarians and vegans may have an insufficient intake of sulphur-containing amino acids that may subsequently affect glutathione values (precursors of its synthesis).

METHODS AND RESULTS

In groups of adults on an alternative diet--lactoovovegetarians (n = 47) and vegans (n = 44) aged 19-62 years with average duration on a vegetarian or vegan diet of 7.6 and 4.9 years, respectively, glutathione levels (GSH) were measured in erythrocytes (spectrophotometrically), as well as the activity of GSH-dependent enzymes. As nutritional control (n = 42) served an average sample of omnivores selected from a group of 489 examined, apparently healthy subjects of the same age range living in the same region. One to low protein intake (56% of RDA) exclusively of plant origin significantly lower levels of total proteins were observed in vegans with a 16% frequency of hypoproteinaemia (vs 0% in omnivores). In comparison to omnivores a significantly lower glutathione level was found (4.28 +/- 0.12 vs 4.84 +/- 0.14 mumol/g Hb, P < 0.01). Lactoovovegetarians because of their protein intake in adequate amounts with a 27% proportion of animal proteins (dairy products, eggs) consume a balanced mixture of amino acids, which is reflected in total protein levels similar to omnivores and significantly higher values of glutathione -5.26 +/- 0.12 mumol/g Hb, P < 0.05 (intake of glutathione in diet, higher consumption of fruit and vegetable in comparison to omnivores). A sufficient supply of glutathione as the substrate for enzymatic reactions of hydrogen peroxide or lipid hydroperoxide catabolism, as well as for detoxication of xenobiotics, was reflected in lactoovovegetarians in a significantly higher activity of glutathione-peroxidase and glutathione-S-transferase in erythrocytes.

CONCLUSIONS

Low protein intake exclusively of plant origin, significantly lower protein levels with 16% frequency of hypoproteinaemia, significantly lower glutathione values in blood in comparison to omnivores and lactoovovegetarians confirm the risk of a vegan diet also in adult age.

Authors+Show Affiliations

Výskumný ústav výzivy, Bratislava.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

slo

PubMed ID

10566232

Citation

Krajcovicová-Kudlácková, M, et al. "[Alternative Nutrition and Glutathione Levels]." Casopis Lekaru Ceskych, vol. 138, no. 17, 1999, pp. 528-31.
Krajcovicová-Kudlácková M, Simoncic R, Béderová A, et al. [Alternative nutrition and glutathione levels]. Cas Lek Cesk. 1999;138(17):528-31.
Krajcovicová-Kudlácková, M., Simoncic, R., Béderová, A., Brtková, A., Magálová, T., & Barteková, S. (1999). [Alternative nutrition and glutathione levels]. Casopis Lekaru Ceskych, 138(17), 528-31.
Krajcovicová-Kudlácková M, et al. [Alternative Nutrition and Glutathione Levels]. Cas Lek Cesk. 1999 Aug 30;138(17):528-31. PubMed PMID: 10566232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Alternative nutrition and glutathione levels]. AU - Krajcovicová-Kudlácková,M, AU - Simoncic,R, AU - Béderová,A, AU - Brtková,A, AU - Magálová,T, AU - Barteková,S, PY - 1999/11/24/pubmed PY - 1999/11/24/medline PY - 1999/11/24/entrez SP - 528 EP - 31 JF - Casopis lekaru ceskych JO - Cas Lek Cesk VL - 138 IS - 17 N2 - BACKGROUND: Low protein quality and quantity is reported to be a possible risk of alternative nutrition. Pulses contain 18-41% of methionine in relation to reference protein, moreover, its content in cereals is by one half lower. Therefore vegetarians and vegans may have an insufficient intake of sulphur-containing amino acids that may subsequently affect glutathione values (precursors of its synthesis). METHODS AND RESULTS: In groups of adults on an alternative diet--lactoovovegetarians (n = 47) and vegans (n = 44) aged 19-62 years with average duration on a vegetarian or vegan diet of 7.6 and 4.9 years, respectively, glutathione levels (GSH) were measured in erythrocytes (spectrophotometrically), as well as the activity of GSH-dependent enzymes. As nutritional control (n = 42) served an average sample of omnivores selected from a group of 489 examined, apparently healthy subjects of the same age range living in the same region. One to low protein intake (56% of RDA) exclusively of plant origin significantly lower levels of total proteins were observed in vegans with a 16% frequency of hypoproteinaemia (vs 0% in omnivores). In comparison to omnivores a significantly lower glutathione level was found (4.28 +/- 0.12 vs 4.84 +/- 0.14 mumol/g Hb, P < 0.01). Lactoovovegetarians because of their protein intake in adequate amounts with a 27% proportion of animal proteins (dairy products, eggs) consume a balanced mixture of amino acids, which is reflected in total protein levels similar to omnivores and significantly higher values of glutathione -5.26 +/- 0.12 mumol/g Hb, P < 0.05 (intake of glutathione in diet, higher consumption of fruit and vegetable in comparison to omnivores). A sufficient supply of glutathione as the substrate for enzymatic reactions of hydrogen peroxide or lipid hydroperoxide catabolism, as well as for detoxication of xenobiotics, was reflected in lactoovovegetarians in a significantly higher activity of glutathione-peroxidase and glutathione-S-transferase in erythrocytes. CONCLUSIONS: Low protein intake exclusively of plant origin, significantly lower protein levels with 16% frequency of hypoproteinaemia, significantly lower glutathione values in blood in comparison to omnivores and lactoovovegetarians confirm the risk of a vegan diet also in adult age. SN - 0008-7335 UR - https://www.unboundmedicine.com/medline/citation/10566232/[Alternative_nutrition_and_glutathione_levels]_ L2 - https://medlineplus.gov/vegetariandiet.html DB - PRIME DP - Unbound Medicine ER -