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A comparison of electrophysiological tests for the early diagnosis of diabetic neuropathy.
Muscle Nerve. 1999 Dec; 22(12):1667-73.MN

Abstract

Clinical criteria and several electrophysiological parameters for detecting nerve damage were compared in 99 patients with diabetes mellitus type 1 and type 2. Abnormal results were found in sural/radial amplitude ratio (51%), minimal F-wave latency of the tibial nerve (36.4%), sensory conduction velocity of the sural nerve (29.8%), and sural sensory nerve action potential amplitude (29.3%) when pooling data from all patients and comparing them to age- and height-matched normal control subjects. Analysis of all the parameters revealed large differences between the diabetes mellitus type 1 and type 2 groups, suggesting that the type of diabetes must be taken into account when comparing the sensitivity of nerve conduction tests. In diabetes mellitus type 1, the sural/radial ratio had the clearest correlation with course of illness and was the first parameter to show a significant reduction. We conclude that the simple ratio between sural and radial amplitudes is a very sensitive parameter and abnormalities in this ratio provide the means for earliest detection of neuropathy in diabetes mellitus type 1.

Authors+Show Affiliations

S. de Neurofisiología Clínica (EMG), Hospital Universitario de San Juan, Ctra. Alicante-Valencia s/n, 03550 San Juan, Alicante, Spain. cpastore@san.gva.esNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

10567079

Citation

Pastore, C, et al. "A Comparison of Electrophysiological Tests for the Early Diagnosis of Diabetic Neuropathy." Muscle & Nerve, vol. 22, no. 12, 1999, pp. 1667-73.
Pastore C, Izura V, Geijo-Barrientos E, et al. A comparison of electrophysiological tests for the early diagnosis of diabetic neuropathy. Muscle Nerve. 1999;22(12):1667-73.
Pastore, C., Izura, V., Geijo-Barrientos, E., & Dominguez, J. R. (1999). A comparison of electrophysiological tests for the early diagnosis of diabetic neuropathy. Muscle & Nerve, 22(12), 1667-73.
Pastore C, et al. A Comparison of Electrophysiological Tests for the Early Diagnosis of Diabetic Neuropathy. Muscle Nerve. 1999;22(12):1667-73. PubMed PMID: 10567079.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of electrophysiological tests for the early diagnosis of diabetic neuropathy. AU - Pastore,C, AU - Izura,V, AU - Geijo-Barrientos,E, AU - Dominguez,J R, PY - 1999/11/24/pubmed PY - 1999/11/24/medline PY - 1999/11/24/entrez SP - 1667 EP - 73 JF - Muscle & nerve JO - Muscle Nerve VL - 22 IS - 12 N2 - Clinical criteria and several electrophysiological parameters for detecting nerve damage were compared in 99 patients with diabetes mellitus type 1 and type 2. Abnormal results were found in sural/radial amplitude ratio (51%), minimal F-wave latency of the tibial nerve (36.4%), sensory conduction velocity of the sural nerve (29.8%), and sural sensory nerve action potential amplitude (29.3%) when pooling data from all patients and comparing them to age- and height-matched normal control subjects. Analysis of all the parameters revealed large differences between the diabetes mellitus type 1 and type 2 groups, suggesting that the type of diabetes must be taken into account when comparing the sensitivity of nerve conduction tests. In diabetes mellitus type 1, the sural/radial ratio had the clearest correlation with course of illness and was the first parameter to show a significant reduction. We conclude that the simple ratio between sural and radial amplitudes is a very sensitive parameter and abnormalities in this ratio provide the means for earliest detection of neuropathy in diabetes mellitus type 1. SN - 0148-639X UR - https://www.unboundmedicine.com/medline/citation/10567079/A_comparison_of_electrophysiological_tests_for_the_early_diagnosis_of_diabetic_neuropathy_ L2 - https://doi.org/10.1002/(sici)1097-4598(199912)22:12<1667::aid-mus8>3.0.co;2-w DB - PRIME DP - Unbound Medicine ER -