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HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics.
Pharm Res. 1999 Nov; 16(11):1748-56.PR

Abstract

PURPOSE

The purpose of this study was to investigate the drug release mechanisms from hydroxypropyl methylcellulose (HPMC)-matrices, and to develop a new model for quantitative predictions of controlled drug delivery.

METHODS

The dissolved mass of pure HPMC-matrices and the drug release rate from propranolol HCl-loaded HPMC-matrices were determined experimentally. Based on Fick's second law of diffusion for cylinders, the transport of water and drug were modeled considering (i) both radial and axial diffusion, (ii) concentration-dependent drug diffusivities, (iii) matrix swelling and (iv) HPMC dissolution.

RESULTS

Good agreement between theory and experiment (dissolved mass and drug release studies) was obtained, proving the validity of the presented model. The water and drug diffusivities are strongly dependent on the matrix swelling ratio. Diffusion, swelling and dissolution are the governing mechanisms involved in the overall drug release process.

CONCLUSIONS

The practical benefit of the presented model is to identify the required shape and dimensions of drug-loaded HPMC-matrices in order to achieve desired release profiles, thus facilitating the development of new controlled drug delivery products. This will be demonstrated in a future study.

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Authors+Show Affiliations

Siepmann J
College of Pharmacy, Freie Universität Berlin, Germany. siepmann@zedat.fu-berlin.de
Kranz H
No affiliation info available
Bodmeier R
No affiliation info available
Peppas NA
No affiliation info available

MeSH

Delayed-Action PreparationsDiffusionLactoseMethylcelluloseModels, ChemicalOxazinesPropranololReproducibility of ResultsSolubilityTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10571282

Citation

Siepmann, J, et al. "HPMC-matrices for Controlled Drug Delivery: a New Model Combining Diffusion, Swelling, and Dissolution Mechanisms and Predicting the Release Kinetics." Pharmaceutical Research, vol. 16, no. 11, 1999, pp. 1748-56.
Siepmann J, Kranz H, Bodmeier R, et al. HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics. Pharm Res. 1999;16(11):1748-56.
Siepmann, J., Kranz, H., Bodmeier, R., & Peppas, N. A. (1999). HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics. Pharmaceutical Research, 16(11), 1748-56.
Siepmann J, et al. HPMC-matrices for Controlled Drug Delivery: a New Model Combining Diffusion, Swelling, and Dissolution Mechanisms and Predicting the Release Kinetics. Pharm Res. 1999;16(11):1748-56. PubMed PMID: 10571282.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics. AU - Siepmann,J, AU - Kranz,H, AU - Bodmeier,R, AU - Peppas,N A, PY - 1999/11/26/pubmed PY - 1999/11/26/medline PY - 1999/11/26/entrez SP - 1748 EP - 56 JF - Pharmaceutical research JO - Pharm Res VL - 16 IS - 11 N2 - PURPOSE: The purpose of this study was to investigate the drug release mechanisms from hydroxypropyl methylcellulose (HPMC)-matrices, and to develop a new model for quantitative predictions of controlled drug delivery. METHODS: The dissolved mass of pure HPMC-matrices and the drug release rate from propranolol HCl-loaded HPMC-matrices were determined experimentally. Based on Fick's second law of diffusion for cylinders, the transport of water and drug were modeled considering (i) both radial and axial diffusion, (ii) concentration-dependent drug diffusivities, (iii) matrix swelling and (iv) HPMC dissolution. RESULTS: Good agreement between theory and experiment (dissolved mass and drug release studies) was obtained, proving the validity of the presented model. The water and drug diffusivities are strongly dependent on the matrix swelling ratio. Diffusion, swelling and dissolution are the governing mechanisms involved in the overall drug release process. CONCLUSIONS: The practical benefit of the presented model is to identify the required shape and dimensions of drug-loaded HPMC-matrices in order to achieve desired release profiles, thus facilitating the development of new controlled drug delivery products. This will be demonstrated in a future study. SN - 0724-8741 UR - https://www.unboundmedicine.com/medline/citation/10571282/HPMC_matrices_for_controlled_drug_delivery:_a_new_model_combining_diffusion_swelling_and_dissolution_mechanisms_and_predicting_the_release_kinetics_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10571282.ui DB - PRIME DP - Unbound Medicine ER -