Tags

Type your tag names separated by a space and hit enter

Nasal mucosa and skin of smear-positive leprosy patients after 24 months of fixed duration MDT: histopathological and microbiological study.
Int J Lepr Other Mycobact Dis. 1999 Sep; 67(3):292-7.IJ

Abstract

The skin and nasal mucosa of 10 lepromatous leprosy patients who had completed 24 doses of fixed duration multidrug therapy (MDT) but who continued to be skin-smear positive for acid-fast bacilli (AFB) were examined histopathologically. The nasal mucosa showed granuloma fractions that exceeded those seen in the skin specimens, signifying that activity in this region subsides much more gradually than the activity in the skin. Mouse foot pad studies done using T900r mice with an inoculum from the nasal mucosa biopsy specimens of these patients did not demonstrate any growth of Mycobacterium leprae, indicating that these bacilli were not viable. A skin specimen from one patient grew significant amounts of bacteria in the T900r mouse foot pad. These results show that 2 years of treatment with MDT would prevent dissemination of M. leprae from the nasal mucosa and, therefore, should preclude further transmission of the disease. It also indicates that viable bacteria might persist in the skin of patients, especially those with an initial bacterial index of > or = 4+ who have completed 24 doses of regular MDT. Therefore, a more cautious approach to administering only 12 doses of MDT to highly positive multibacillary patients is suggested.

Authors+Show Affiliations

Department of Histopathology and Experimental Pathology, Schieffelin Leprosy Research and Training Center, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10575409

Citation

Ebenezer, G J., et al. "Nasal Mucosa and Skin of Smear-positive Leprosy Patients After 24 Months of Fixed Duration MDT: Histopathological and Microbiological Study." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 67, no. 3, 1999, pp. 292-7.
Ebenezer GJ, Job A, Abraham S, et al. Nasal mucosa and skin of smear-positive leprosy patients after 24 months of fixed duration MDT: histopathological and microbiological study. Int J Lepr Other Mycobact Dis. 1999;67(3):292-7.
Ebenezer, G. J., Job, A., Abraham, S., Arunthathi, S., Rao, P. S., & Job, C. K. (1999). Nasal mucosa and skin of smear-positive leprosy patients after 24 months of fixed duration MDT: histopathological and microbiological study. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 67(3), 292-7.
Ebenezer GJ, et al. Nasal Mucosa and Skin of Smear-positive Leprosy Patients After 24 Months of Fixed Duration MDT: Histopathological and Microbiological Study. Int J Lepr Other Mycobact Dis. 1999;67(3):292-7. PubMed PMID: 10575409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasal mucosa and skin of smear-positive leprosy patients after 24 months of fixed duration MDT: histopathological and microbiological study. AU - Ebenezer,G J, AU - Job,A, AU - Abraham,S, AU - Arunthathi,S, AU - Rao,P S, AU - Job,C K, PY - 1999/11/27/pubmed PY - 1999/11/27/medline PY - 1999/11/27/entrez SP - 292 EP - 7 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 67 IS - 3 N2 - The skin and nasal mucosa of 10 lepromatous leprosy patients who had completed 24 doses of fixed duration multidrug therapy (MDT) but who continued to be skin-smear positive for acid-fast bacilli (AFB) were examined histopathologically. The nasal mucosa showed granuloma fractions that exceeded those seen in the skin specimens, signifying that activity in this region subsides much more gradually than the activity in the skin. Mouse foot pad studies done using T900r mice with an inoculum from the nasal mucosa biopsy specimens of these patients did not demonstrate any growth of Mycobacterium leprae, indicating that these bacilli were not viable. A skin specimen from one patient grew significant amounts of bacteria in the T900r mouse foot pad. These results show that 2 years of treatment with MDT would prevent dissemination of M. leprae from the nasal mucosa and, therefore, should preclude further transmission of the disease. It also indicates that viable bacteria might persist in the skin of patients, especially those with an initial bacterial index of > or = 4+ who have completed 24 doses of regular MDT. Therefore, a more cautious approach to administering only 12 doses of MDT to highly positive multibacillary patients is suggested. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/10575409/Nasal_mucosa_and_skin_of_smear_positive_leprosy_patients_after_24_months_of_fixed_duration_MDT:_histopathological_and_microbiological_study_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -