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Gastroduodenal perforation in cancer patients.
Hepatogastroenterology. 1999 Sep-Oct; 46(29):2878-81.H

Abstract

BACKGROUND/AIMS

Patients with advanced or metastatic cancer have compromised nutritional, metabolic, and immune conditions. Little is known about gastroduodenal perforation in cancer patients.

METHODOLOGY

Data of 11 cancer patients with gastroduodenal perforation were retrospectively reviewed.

RESULTS

There were 2 females and 9 males with a mean (+/- s.e.) age of 56.7+/-4.7 years and a median of 55. The primary malignancies included lung cancers (3 cases), hepatocellular carcinomas (2 cases), squamous cell carcinomas of the tongue (2 cases), malignant lymphoma of the small bowel (1 case), adenocarcinoma of the pancreas (1 case), adenocarcinoma of the stomach (1 case), and acute lymphoblastic leukemia (1 case). The average duration of symptoms was 36.5+/-10.1 hours (median: 24 hours). Methods of surgical treatment included simple closure of the perforation (6 cases), truncal vagotomy and pyloroplasty (3 cases), pyloroplasty (1 case), and subtotal gastrectomy (1 case). Four patients (36.4%) had post-operative complications. The post-operative hospital mortality rate was 18.2%. One patient died of sepsis with gastrointestinal hemorrhage and 1 died of hepatic failure and respiratory failure. Pre-operative shock is the only significant factor in predicting operative mortality.

CONCLUSIONS

Gastroduodenal perforation occurring in cancer patients without chemotherapy had favorable short-term operative results.

Authors+Show Affiliations

Department of Surgery, Chang Gung University College of Medicine, Taipei, Taiwan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10576365

Citation

Chao, T C., et al. "Gastroduodenal Perforation in Cancer Patients." Hepato-gastroenterology, vol. 46, no. 29, 1999, pp. 2878-81.
Chao TC, Wang CS, Chen MF. Gastroduodenal perforation in cancer patients. Hepatogastroenterology. 1999;46(29):2878-81.
Chao, T. C., Wang, C. S., & Chen, M. F. (1999). Gastroduodenal perforation in cancer patients. Hepato-gastroenterology, 46(29), 2878-81.
Chao TC, Wang CS, Chen MF. Gastroduodenal Perforation in Cancer Patients. Hepatogastroenterology. 1999 Sep-Oct;46(29):2878-81. PubMed PMID: 10576365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroduodenal perforation in cancer patients. AU - Chao,T C, AU - Wang,C S, AU - Chen,M F, PY - 1999/11/27/pubmed PY - 1999/11/27/medline PY - 1999/11/27/entrez SP - 2878 EP - 81 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 46 IS - 29 N2 - BACKGROUND/AIMS: Patients with advanced or metastatic cancer have compromised nutritional, metabolic, and immune conditions. Little is known about gastroduodenal perforation in cancer patients. METHODOLOGY: Data of 11 cancer patients with gastroduodenal perforation were retrospectively reviewed. RESULTS: There were 2 females and 9 males with a mean (+/- s.e.) age of 56.7+/-4.7 years and a median of 55. The primary malignancies included lung cancers (3 cases), hepatocellular carcinomas (2 cases), squamous cell carcinomas of the tongue (2 cases), malignant lymphoma of the small bowel (1 case), adenocarcinoma of the pancreas (1 case), adenocarcinoma of the stomach (1 case), and acute lymphoblastic leukemia (1 case). The average duration of symptoms was 36.5+/-10.1 hours (median: 24 hours). Methods of surgical treatment included simple closure of the perforation (6 cases), truncal vagotomy and pyloroplasty (3 cases), pyloroplasty (1 case), and subtotal gastrectomy (1 case). Four patients (36.4%) had post-operative complications. The post-operative hospital mortality rate was 18.2%. One patient died of sepsis with gastrointestinal hemorrhage and 1 died of hepatic failure and respiratory failure. Pre-operative shock is the only significant factor in predicting operative mortality. CONCLUSIONS: Gastroduodenal perforation occurring in cancer patients without chemotherapy had favorable short-term operative results. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/10576365/Gastroduodenal_perforation_in_cancer_patients_ DB - PRIME DP - Unbound Medicine ER -