Tags

Type your tag names separated by a space and hit enter

Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis.
Ann Intern Med. 1999 Nov 02; 131(9):668-72.AIM

Abstract

BACKGROUND

Iron deficiency anemia is the most common form of anemia worldwide. Recent studies have suggested an association between Helicobacter pylori infection and iron deficiency.

OBJECTIVE

To investigate the effects of eradicating H. pylori with combination antibiotic therapy on iron deficiency anemia in patients with H. pylori-associated gastritis.

DESIGN

Case series.

SETTING

University hospital.

PATIENTS

30 patients with a long history of iron deficiency anemia in whom H. pylori-associated gastritis was the only pathologic gastrointestinal finding detected.

INTERVENTION

Eradication therapy with two antibiotics and discontinuation of iron replacement therapy.

MEASUREMENTS

Complete blood count, ferritin levels, and gastroscopy with biopsy to evaluate H. pylori status.

RESULTS

At 6 months, 75% of patients had recovered from anemia (P<0.001), ferritin values increased from 5.7+/-0.7 microg/L to 24.5+/-5.2 microg/L (95% CI, 8.85 to 29.97). After 12 months, 91.7% of patients had recovered from anemia.

CONCLUSIONS

Cure of H. pylori infection is associated with reversal of iron dependence and recovery from iron deficiency anemia.

Authors+Show Affiliations

University La Sapienza, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10577329

Citation

Annibale, B, et al. "Reversal of Iron Deficiency Anemia After Helicobacter Pylori Eradication in Patients With Asymptomatic Gastritis." Annals of Internal Medicine, vol. 131, no. 9, 1999, pp. 668-72.
Annibale B, Marignani M, Monarca B, et al. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med. 1999;131(9):668-72.
Annibale, B., Marignani, M., Monarca, B., Antonelli, G., Marcheggiano, A., Martino, G., Mandelli, F., Caprilli, R., & Delle Fave, G. (1999). Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Annals of Internal Medicine, 131(9), 668-72.
Annibale B, et al. Reversal of Iron Deficiency Anemia After Helicobacter Pylori Eradication in Patients With Asymptomatic Gastritis. Ann Intern Med. 1999 Nov 2;131(9):668-72. PubMed PMID: 10577329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. AU - Annibale,B, AU - Marignani,M, AU - Monarca,B, AU - Antonelli,G, AU - Marcheggiano,A, AU - Martino,G, AU - Mandelli,F, AU - Caprilli,R, AU - Delle Fave,G, PY - 1999/11/30/pubmed PY - 2000/9/8/medline PY - 1999/11/30/entrez SP - 668 EP - 72 JF - Annals of internal medicine JO - Ann Intern Med VL - 131 IS - 9 N2 - BACKGROUND: Iron deficiency anemia is the most common form of anemia worldwide. Recent studies have suggested an association between Helicobacter pylori infection and iron deficiency. OBJECTIVE: To investigate the effects of eradicating H. pylori with combination antibiotic therapy on iron deficiency anemia in patients with H. pylori-associated gastritis. DESIGN: Case series. SETTING: University hospital. PATIENTS: 30 patients with a long history of iron deficiency anemia in whom H. pylori-associated gastritis was the only pathologic gastrointestinal finding detected. INTERVENTION: Eradication therapy with two antibiotics and discontinuation of iron replacement therapy. MEASUREMENTS: Complete blood count, ferritin levels, and gastroscopy with biopsy to evaluate H. pylori status. RESULTS: At 6 months, 75% of patients had recovered from anemia (P<0.001), ferritin values increased from 5.7+/-0.7 microg/L to 24.5+/-5.2 microg/L (95% CI, 8.85 to 29.97). After 12 months, 91.7% of patients had recovered from anemia. CONCLUSIONS: Cure of H. pylori infection is associated with reversal of iron dependence and recovery from iron deficiency anemia. SN - 0003-4819 UR - https://www.unboundmedicine.com/medline/citation/10577329/Reversal_of_iron_deficiency_anemia_after_Helicobacter_pylori_eradication_in_patients_with_asymptomatic_gastritis_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-131-9-199911020-00006?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -