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Serologic evaluation of patients with primary and recurrent ocular toxoplasmosis for evidence of recent infection.
Am J Ophthalmol 1999; 128(4):407-12AJ

Abstract

PURPOSE

To identify the frequency of recently acquired vs chronic systemic Toxoplasma gondii infections in patients with ocular toxoplasmosis.

METHODS

Serum samples from 22 patients with primary ocular toxoplasmosis (not from scars) and 42 patients with recurrent ocular toxoplasmosis were tested for the presence of anti-T. gondii IgM, IgG, and IgA antibodies and compared with samples from 24 patients with other causes of uveitis. Intraocular production of anti-T. gondii IgG and IgA, and the presence of T. gondii DNA was determined in patient s and control subjects from whom ocular fluid was available.

RESULTS

Serologic evidence of recently acquired infection was found for 11 (50%) of 22 patients with primary ocular toxoplasmosis and for one (2%) of 42 with recurrent ocular toxoplasmosis. In the uveitis control group, anti-T. gondii IgM antibodies could be detected in two (8%) of 24 patients, but anti-T. gondii IgA antibodies were not detectable. Patients with primary ocular toxoplasmosis and serologic markers of recently acquired systemic infection were significantly older than those with chronic infection (P = .008). Intraocular production of anti-T. gondii IgG was more frequently noted in patients with recurrent than primary ocular toxoplasmosis (81% vs 41%; P < .001), but intraocular T. gondii DNA was more frequently found in patients with primary ocular toxoplasmosis than in those with recurrent ocular toxoplasmosis (37% vs 4%; P < .01).

CONCLUSIONS

Primary ocular toxoplasmosis can be seen in either recently acquired or chronic T. gondii infection. Patients with ocular disease and recently acquired infection were older and more likely to have T. gondii DNA in intraocular fluids.

Authors+Show Affiliations

Department of Ophthalmology, Academic Medical Center, Netherlands Ophthalmic Research Institute, Amsterdam. j.v.ongkosuwito@amc.uva.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10577580

Citation

Ongkosuwito, J V., et al. "Serologic Evaluation of Patients With Primary and Recurrent Ocular Toxoplasmosis for Evidence of Recent Infection." American Journal of Ophthalmology, vol. 128, no. 4, 1999, pp. 407-12.
Ongkosuwito JV, Bosch-Driessen EH, Kijlstra A, et al. Serologic evaluation of patients with primary and recurrent ocular toxoplasmosis for evidence of recent infection. Am J Ophthalmol. 1999;128(4):407-12.
Ongkosuwito, J. V., Bosch-Driessen, E. H., Kijlstra, A., & Rothova, A. (1999). Serologic evaluation of patients with primary and recurrent ocular toxoplasmosis for evidence of recent infection. American Journal of Ophthalmology, 128(4), pp. 407-12.
Ongkosuwito JV, et al. Serologic Evaluation of Patients With Primary and Recurrent Ocular Toxoplasmosis for Evidence of Recent Infection. Am J Ophthalmol. 1999;128(4):407-12. PubMed PMID: 10577580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serologic evaluation of patients with primary and recurrent ocular toxoplasmosis for evidence of recent infection. AU - Ongkosuwito,J V, AU - Bosch-Driessen,E H, AU - Kijlstra,A, AU - Rothova,A, PY - 1999/11/30/pubmed PY - 1999/11/30/medline PY - 1999/11/30/entrez SP - 407 EP - 12 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 128 IS - 4 N2 - PURPOSE: To identify the frequency of recently acquired vs chronic systemic Toxoplasma gondii infections in patients with ocular toxoplasmosis. METHODS: Serum samples from 22 patients with primary ocular toxoplasmosis (not from scars) and 42 patients with recurrent ocular toxoplasmosis were tested for the presence of anti-T. gondii IgM, IgG, and IgA antibodies and compared with samples from 24 patients with other causes of uveitis. Intraocular production of anti-T. gondii IgG and IgA, and the presence of T. gondii DNA was determined in patient s and control subjects from whom ocular fluid was available. RESULTS: Serologic evidence of recently acquired infection was found for 11 (50%) of 22 patients with primary ocular toxoplasmosis and for one (2%) of 42 with recurrent ocular toxoplasmosis. In the uveitis control group, anti-T. gondii IgM antibodies could be detected in two (8%) of 24 patients, but anti-T. gondii IgA antibodies were not detectable. Patients with primary ocular toxoplasmosis and serologic markers of recently acquired systemic infection were significantly older than those with chronic infection (P = .008). Intraocular production of anti-T. gondii IgG was more frequently noted in patients with recurrent than primary ocular toxoplasmosis (81% vs 41%; P < .001), but intraocular T. gondii DNA was more frequently found in patients with primary ocular toxoplasmosis than in those with recurrent ocular toxoplasmosis (37% vs 4%; P < .01). CONCLUSIONS: Primary ocular toxoplasmosis can be seen in either recently acquired or chronic T. gondii infection. Patients with ocular disease and recently acquired infection were older and more likely to have T. gondii DNA in intraocular fluids. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/10577580/Serologic_evaluation_of_patients_with_primary_and_recurrent_ocular_toxoplasmosis_for_evidence_of_recent_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002939499002664 DB - PRIME DP - Unbound Medicine ER -