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[Fournier's gangrene].
Ned Tijdschr Geneeskd. 1999 Oct 30; 143(44):2177-81.NT

Abstract

Fournier's gangrene is a rapidly progressive, necrotizing fasciitis of the perineal, genital or perianal regions. Despite increasing knowledge about aetiology, diagnostic procedures and treatment, the gangrene is still a destructive and potentially lethal disease. In two patients, men aged 54 and 63 years, Fournier's gangrene was diagnosed. The first one died of septic shock 12 hours after admission. Surgical débridement had been performed immediately. He had a latent promyelocytic leukaemia. The second patient recovered fully after extensive surgical and antimicrobial therapy. Fournier's gangrene appears to be caused by the synergistic pathogenic action of various individually non-pathogenic commensal bacteria. Virtually all patients have an underlying systemic disorder, mainly chronic alcoholism or diabetes mellitus. Immunosupression is a predisposing factor. The gangrene requires an aggressive approach, treatment being based on the combination of haemodynamic stabilisation, antibiotic triple therapy and radical surgical débridement.

Authors+Show Affiliations

Medisch Centrum Leeuwarden, afd. Urologie.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Review

Language

dut

PubMed ID

10578408

Citation

Pol, A G., et al. "[Fournier's Gangrene]." Nederlands Tijdschrift Voor Geneeskunde, vol. 143, no. 44, 1999, pp. 2177-81.
Pol AG, Groeneveld AE, de Jong IJ, et al. [Fournier's gangrene]. Ned Tijdschr Geneeskd. 1999;143(44):2177-81.
Pol, A. G., Groeneveld, A. E., de Jong, I. J., & Mensink, H. J. (1999). [Fournier's gangrene]. Nederlands Tijdschrift Voor Geneeskunde, 143(44), 2177-81.
Pol AG, et al. [Fournier's Gangrene]. Ned Tijdschr Geneeskd. 1999 Oct 30;143(44):2177-81. PubMed PMID: 10578408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fournier's gangrene]. AU - Pol,A G, AU - Groeneveld,A E, AU - de Jong,I J, AU - Mensink,H J, PY - 1999/12/1/pubmed PY - 1999/12/1/medline PY - 1999/12/1/entrez SP - 2177 EP - 81 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 143 IS - 44 N2 - Fournier's gangrene is a rapidly progressive, necrotizing fasciitis of the perineal, genital or perianal regions. Despite increasing knowledge about aetiology, diagnostic procedures and treatment, the gangrene is still a destructive and potentially lethal disease. In two patients, men aged 54 and 63 years, Fournier's gangrene was diagnosed. The first one died of septic shock 12 hours after admission. Surgical débridement had been performed immediately. He had a latent promyelocytic leukaemia. The second patient recovered fully after extensive surgical and antimicrobial therapy. Fournier's gangrene appears to be caused by the synergistic pathogenic action of various individually non-pathogenic commensal bacteria. Virtually all patients have an underlying systemic disorder, mainly chronic alcoholism or diabetes mellitus. Immunosupression is a predisposing factor. The gangrene requires an aggressive approach, treatment being based on the combination of haemodynamic stabilisation, antibiotic triple therapy and radical surgical débridement. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/10578408/[Fournier's_gangrene]_ DB - PRIME DP - Unbound Medicine ER -