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Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study.

Abstract

Controversy persists about the etiology of Parkinson's disease (PD). Pesticides, herbicides, well-water consumption, head injury, and a family history of PD have been reported as risk factors for PD. The purpose of this study was to (1) investigate the impact of environmental factors on PD risk (2) estimate the chronology, frequency, and duration of those exposures associated with PD; and (3) investigate the effects of family history on PD risk. One-hundred and forty PD cases were recruited from Boston University Medical Center. The control group was composed of 147 friends and in-laws of PD patients. Environmental, medical, and family history data were obtained by structured interview from each participant for events recalled prior to PD onset for cases, or corresponding censoring age for controls (mean age = 56 years of age for each group). A traditional stratified analysis, adjusting for birth cohort and sex, was employed. Four factors were associated with increased risk for PD: (1) head injury (OR=6.23, confidence interval [CI]: 2.58-15.07); (2) family history of PD (OR=6.08, CI: 2.35-15. 58); (3) family history of tremor (OR=3.97, CI: 1.17-13.50); and (4) history of depression (OR=3.01, CI: 1.32-6.88). A mean latency of 36. 5 (SE=2.81) years passed between the age of first reported head injury and PD onset. A mean latency of 22 (SE=2.66) years passed between the onset of the first reported symptoms of depression and onset of PD. Years of education, smoking, and well-water intake were inversely associated with PD risk. PD was not associated with exposure to pesticides or herbicides. These findings support the role of both environmental and genetic factors in the etiology in PD. The results are consistent with a multifactorial model. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:742-749, 1999.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.

    , , , , ,

    Source

    American journal of medical genetics 88:6 1999 Dec 15 pg 742-9

    MeSH

    Adult
    Age of Onset
    Aged
    Aged, 80 and over
    Case-Control Studies
    Craniocerebral Trauma
    Demography
    Depression
    Environmental Exposure
    Family Health
    Female
    Genetic Predisposition to Disease
    Humans
    Interviews as Topic
    Male
    Middle Aged
    New England
    Parkinson Disease
    Parkinson Disease, Secondary
    Risk Factors
    Smoking
    Tremor

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10581500

    Citation

    Taylor, C A., et al. "Environmental, Medical, and Family History Risk Factors for Parkinson's Disease: a New England-based Case Control Study." American Journal of Medical Genetics, vol. 88, no. 6, 1999, pp. 742-9.
    Taylor CA, Saint-Hilaire MH, Cupples LA, et al. Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study. Am J Med Genet. 1999;88(6):742-9.
    Taylor, C. A., Saint-Hilaire, M. H., Cupples, L. A., Thomas, C. A., Burchard, A. E., Feldman, R. G., & Myers, R. H. (1999). Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study. American Journal of Medical Genetics, 88(6), pp. 742-9.
    Taylor CA, et al. Environmental, Medical, and Family History Risk Factors for Parkinson's Disease: a New England-based Case Control Study. Am J Med Genet. 1999 Dec 15;88(6):742-9. PubMed PMID: 10581500.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Environmental, medical, and family history risk factors for Parkinson's disease: a New England-based case control study. AU - Taylor,C A, AU - Saint-Hilaire,M H, AU - Cupples,L A, AU - Thomas,C A, AU - Burchard,A E, AU - Feldman,R G, AU - Myers,R H, PY - 1999/12/3/pubmed PY - 2000/2/26/medline PY - 1999/12/3/entrez SP - 742 EP - 9 JF - American journal of medical genetics JO - Am. J. Med. Genet. VL - 88 IS - 6 N2 - Controversy persists about the etiology of Parkinson's disease (PD). Pesticides, herbicides, well-water consumption, head injury, and a family history of PD have been reported as risk factors for PD. The purpose of this study was to (1) investigate the impact of environmental factors on PD risk (2) estimate the chronology, frequency, and duration of those exposures associated with PD; and (3) investigate the effects of family history on PD risk. One-hundred and forty PD cases were recruited from Boston University Medical Center. The control group was composed of 147 friends and in-laws of PD patients. Environmental, medical, and family history data were obtained by structured interview from each participant for events recalled prior to PD onset for cases, or corresponding censoring age for controls (mean age = 56 years of age for each group). A traditional stratified analysis, adjusting for birth cohort and sex, was employed. Four factors were associated with increased risk for PD: (1) head injury (OR=6.23, confidence interval [CI]: 2.58-15.07); (2) family history of PD (OR=6.08, CI: 2.35-15. 58); (3) family history of tremor (OR=3.97, CI: 1.17-13.50); and (4) history of depression (OR=3.01, CI: 1.32-6.88). A mean latency of 36. 5 (SE=2.81) years passed between the age of first reported head injury and PD onset. A mean latency of 22 (SE=2.66) years passed between the onset of the first reported symptoms of depression and onset of PD. Years of education, smoking, and well-water intake were inversely associated with PD risk. PD was not associated with exposure to pesticides or herbicides. These findings support the role of both environmental and genetic factors in the etiology in PD. The results are consistent with a multifactorial model. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:742-749, 1999. SN - 0148-7299 UR - https://www.unboundmedicine.com/medline/citation/10581500/Environmental_medical_and_family_history_risk_factors_for_Parkinson's_disease:_a_New_England_based_case_control_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0148-7299&date=1999&volume=88&issue=6&spage=742 DB - PRIME DP - Unbound Medicine ER -