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24-h pH monitoring is necessary to assess acid reflux suppression in patients with Barrett's oesophagus undergoing treatment with proton pump inhibitors.
Br J Surg 1999; 86(11):1472-4BJ

Abstract

BACKGROUND

Control of acid reflux is the main objective of treatment for Barrett's oesophagus. However, as these patients have a reduced sensitivity to acid reflux, disappearance of symptoms may not correlate with efficient control of acid reflux. The aim of this study was to determine in a group of patients with Barrett's oesophagus whether treatment with proton pump inhibitors suppressed pathological acid reflux once the symptoms of reflux had been controlled and the associated inflammatory lesions cured.

METHODS

Eighteen consecutive patients with Barrett's oesophagus were studied, all of whom presented with heartburn. Twenty-four-hour oesophageal pH monitoring before treatment showed pathological acid reflux in all cases: median percentage of total time with pH less than 4, 22 (range 8-52) per cent. All patients received proton pump inhibitors (dose 20-60 mg/day) until symptoms were controlled.

RESULTS

While on therapy, pH was reduced (median percentage of total time with pH less than 4, 3 versus 22 per cent; P < 0.001). However, three patients had persistent pathological rates of acid reflux.

CONCLUSION

Disappearance of symptoms is not a good indicator of control of pathological acid reflux in patients with Barrett's oesophagus. Twenty-four-hour pH monitoring should be performed for proper adjustment of the dose of medication.

Authors+Show Affiliations

Department of Surgery, University Hospital Virgen de la Arrixaca, El Palmar, Murcia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10583299

Citation

Ortiz, A, et al. "24-h pH Monitoring Is Necessary to Assess Acid Reflux Suppression in Patients With Barrett's Oesophagus Undergoing Treatment With Proton Pump Inhibitors." The British Journal of Surgery, vol. 86, no. 11, 1999, pp. 1472-4.
Ortiz A, Martínez de Haro LF, Parrilla P, et al. 24-h pH monitoring is necessary to assess acid reflux suppression in patients with Barrett's oesophagus undergoing treatment with proton pump inhibitors. Br J Surg. 1999;86(11):1472-4.
Ortiz, A., Martínez de Haro, L. F., Parrilla, P., Molina, J., Bermejo, J., & Munitiz, V. (1999). 24-h pH monitoring is necessary to assess acid reflux suppression in patients with Barrett's oesophagus undergoing treatment with proton pump inhibitors. The British Journal of Surgery, 86(11), pp. 1472-4.
Ortiz A, et al. 24-h pH Monitoring Is Necessary to Assess Acid Reflux Suppression in Patients With Barrett's Oesophagus Undergoing Treatment With Proton Pump Inhibitors. Br J Surg. 1999;86(11):1472-4. PubMed PMID: 10583299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 24-h pH monitoring is necessary to assess acid reflux suppression in patients with Barrett's oesophagus undergoing treatment with proton pump inhibitors. AU - Ortiz,A, AU - Martínez de Haro,L F, AU - Parrilla,P, AU - Molina,J, AU - Bermejo,J, AU - Munitiz,V, PY - 1999/12/3/pubmed PY - 1999/12/3/medline PY - 1999/12/3/entrez SP - 1472 EP - 4 JF - The British journal of surgery JO - Br J Surg VL - 86 IS - 11 N2 - BACKGROUND: Control of acid reflux is the main objective of treatment for Barrett's oesophagus. However, as these patients have a reduced sensitivity to acid reflux, disappearance of symptoms may not correlate with efficient control of acid reflux. The aim of this study was to determine in a group of patients with Barrett's oesophagus whether treatment with proton pump inhibitors suppressed pathological acid reflux once the symptoms of reflux had been controlled and the associated inflammatory lesions cured. METHODS: Eighteen consecutive patients with Barrett's oesophagus were studied, all of whom presented with heartburn. Twenty-four-hour oesophageal pH monitoring before treatment showed pathological acid reflux in all cases: median percentage of total time with pH less than 4, 22 (range 8-52) per cent. All patients received proton pump inhibitors (dose 20-60 mg/day) until symptoms were controlled. RESULTS: While on therapy, pH was reduced (median percentage of total time with pH less than 4, 3 versus 22 per cent; P < 0.001). However, three patients had persistent pathological rates of acid reflux. CONCLUSION: Disappearance of symptoms is not a good indicator of control of pathological acid reflux in patients with Barrett's oesophagus. Twenty-four-hour pH monitoring should be performed for proper adjustment of the dose of medication. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/10583299/24_h_pH_monitoring_is_necessary_to_assess_acid_reflux_suppression_in_patients_with_Barrett's_oesophagus_undergoing_treatment_with_proton_pump_inhibitors_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0007-1323&amp;date=1999&amp;volume=86&amp;issue=11&amp;spage=1472 DB - PRIME DP - Unbound Medicine ER -