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Worsening of motor features of parkinsonism with olanzapine.
Mov Disord. 1999 Nov; 14(6):1014-6.MD

Abstract

Clozapine is the current treatment of choice for drug-induced psychosis (DIP) occurring in Parkinson's disease. However, alternative medications have been sought because of the small but significant risk of agranulocytosis and the need for frequent blood testing. The new "atypical" antipsychotic olanzapine (OLZ) has recently been proposed as a safe and effective option for treating psychosis in this setting. To investigate this, we retrospectively evaluated all 12 of our patients treated with OLZ for DIP. Symptoms of psychosis were improved in nine of 12 patients, but nine of 12 patients also experienced worsening of motor functioning while on OLZ. The worsening was considered dramatic in six of these patients. Overall, there was no significant increase in levodopa doses on OLZ. Only one patient remained on OLZ at the time of the analysis. Nine patients were switched to alternative treatment for DIP. We conclude that although OLZ may improve symptoms of psychosis in parkinsonian patients, it can also worsen motor functioning. In some patients, the degree of motor worsening may be intolerable.

Authors+Show Affiliations

Department of Neurology, Albany Medical College, New York, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10584679

Citation

Molho, E S., and S A. Factor. "Worsening of Motor Features of Parkinsonism With Olanzapine." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 14, no. 6, 1999, pp. 1014-6.
Molho ES, Factor SA. Worsening of motor features of parkinsonism with olanzapine. Mov Disord. 1999;14(6):1014-6.
Molho, E. S., & Factor, S. A. (1999). Worsening of motor features of parkinsonism with olanzapine. Movement Disorders : Official Journal of the Movement Disorder Society, 14(6), 1014-6.
Molho ES, Factor SA. Worsening of Motor Features of Parkinsonism With Olanzapine. Mov Disord. 1999;14(6):1014-6. PubMed PMID: 10584679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Worsening of motor features of parkinsonism with olanzapine. AU - Molho,E S, AU - Factor,S A, PY - 1999/12/10/pubmed PY - 1999/12/10/medline PY - 1999/12/10/entrez SP - 1014 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 14 IS - 6 N2 - Clozapine is the current treatment of choice for drug-induced psychosis (DIP) occurring in Parkinson's disease. However, alternative medications have been sought because of the small but significant risk of agranulocytosis and the need for frequent blood testing. The new "atypical" antipsychotic olanzapine (OLZ) has recently been proposed as a safe and effective option for treating psychosis in this setting. To investigate this, we retrospectively evaluated all 12 of our patients treated with OLZ for DIP. Symptoms of psychosis were improved in nine of 12 patients, but nine of 12 patients also experienced worsening of motor functioning while on OLZ. The worsening was considered dramatic in six of these patients. Overall, there was no significant increase in levodopa doses on OLZ. Only one patient remained on OLZ at the time of the analysis. Nine patients were switched to alternative treatment for DIP. We conclude that although OLZ may improve symptoms of psychosis in parkinsonian patients, it can also worsen motor functioning. In some patients, the degree of motor worsening may be intolerable. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/10584679/Worsening_of_motor_features_of_parkinsonism_with_olanzapine_ L2 - https://doi.org/10.1002/1531-8257(199911)14:6<1014::aid-mds1017>3.0.co;2-9 DB - PRIME DP - Unbound Medicine ER -