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Cow's milk and intestinal blood loss in late infancy.
J Pediatr. 1999 Dec; 135(6):720-6.JPed

Abstract

OBJECTIVES

Young infants commonly show occult intestinal blood loss when fed cow's milk, but in older infants blood loss may be less common. This study examined intestinal blood loss in response to cow's milk feeding in normal 7(1/2)-month-old and 12-month-old infants.

STUDY DESIGN

Infants (n = 62) were fed formula for 1 month and then pasteurized cow's milk for 2 months. Stools were collected for quantitative determination of hemoglobin. Iron nutritional status was assessed.

RESULTS

Infants fed cow's milk from 7(1/2) months of age showed a significant increase in guaiac-positive stools and in stool hemoglobin concentration. These effects were largely limited to those infants who had been breast fed early in life. Infants fed cow's milk from 12 months of age at baseline had greater stool hemoglobin concentrations than 7(1/2)-month-old infants, but cow's milk produced no significant increase. In neither age group did cow's milk affect iron nutritional status.

CONCLUSION

The response to cow's milk is attenuated in infants aged 7(1/2) months compared with younger infants. By 12 months of age, the response has disappeared entirely. We conclude that the gastrointestinal tract of healthy infants gradually loses its responsiveness to cow's milk.

Authors+Show Affiliations

Fomon Infant Nutrition Unit, Department of Pediatrics, University of Iowa, Iowa City 52242, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10586175

Citation

Ziegler, E E., et al. "Cow's Milk and Intestinal Blood Loss in Late Infancy." The Journal of Pediatrics, vol. 135, no. 6, 1999, pp. 720-6.
Ziegler EE, Jiang T, Romero E, et al. Cow's milk and intestinal blood loss in late infancy. J Pediatr. 1999;135(6):720-6.
Ziegler, E. E., Jiang, T., Romero, E., Vinco, A., Frantz, J. A., & Nelson, S. E. (1999). Cow's milk and intestinal blood loss in late infancy. The Journal of Pediatrics, 135(6), 720-6.
Ziegler EE, et al. Cow's Milk and Intestinal Blood Loss in Late Infancy. J Pediatr. 1999;135(6):720-6. PubMed PMID: 10586175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cow's milk and intestinal blood loss in late infancy. AU - Ziegler,E E, AU - Jiang,T, AU - Romero,E, AU - Vinco,A, AU - Frantz,J A, AU - Nelson,S E, PY - 1999/12/10/pubmed PY - 1999/12/10/medline PY - 1999/12/10/entrez SP - 720 EP - 6 JF - The Journal of pediatrics JO - J Pediatr VL - 135 IS - 6 N2 - OBJECTIVES: Young infants commonly show occult intestinal blood loss when fed cow's milk, but in older infants blood loss may be less common. This study examined intestinal blood loss in response to cow's milk feeding in normal 7(1/2)-month-old and 12-month-old infants. STUDY DESIGN: Infants (n = 62) were fed formula for 1 month and then pasteurized cow's milk for 2 months. Stools were collected for quantitative determination of hemoglobin. Iron nutritional status was assessed. RESULTS: Infants fed cow's milk from 7(1/2) months of age showed a significant increase in guaiac-positive stools and in stool hemoglobin concentration. These effects were largely limited to those infants who had been breast fed early in life. Infants fed cow's milk from 12 months of age at baseline had greater stool hemoglobin concentrations than 7(1/2)-month-old infants, but cow's milk produced no significant increase. In neither age group did cow's milk affect iron nutritional status. CONCLUSION: The response to cow's milk is attenuated in infants aged 7(1/2) months compared with younger infants. By 12 months of age, the response has disappeared entirely. We conclude that the gastrointestinal tract of healthy infants gradually loses its responsiveness to cow's milk. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/10586175/Cow's_milk_and_intestinal_blood_loss_in_late_infancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(99)70091-0 DB - PRIME DP - Unbound Medicine ER -