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Positron emission tomography with fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) does not visualize extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)-type.
Ann Oncol. 1999 Oct; 10(10):1185-9.AO

Abstract

BACKGROUND

On the basis of promising data on the use of fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) whole body positron emission tomography (WB-FDG-PET) in the staging of patients with lymphoma, we initiated a pilot series to evaluate the role of WB-FDG-PET in the staging of extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type.

PATIENTS AND METHODS

We examined ten consecutive patients with histologically-verified MALT-type lymphomas of various origin before initiation of therapy. Nine patients had low-grade lymphomas (five cases of gastric lymphoma, two patients with lymphoma arising in the lung, one parotid and one lacrimal gland lymphoma), while one patient had a high-grade gastric lymphoma arising from a low-grade background. Two patients had stage EI, seven had stage EII disease, and one presented with stage EIII. WB-FDG-PET scans were performed 40 min following the injection of 300-380 MBq of F18-FDG. The PET scans were correlated with extensive conventional staging including ophthalmologic investigation, otolaryngologic examination, gastroscopy, endosonography, enteroclysis, colonoscopy, CT of thorax and abdomen, and bone marrow biopsy.

RESULTS

WB-FDG-PET documented no lymphoma in any of the 10 patients studied, as no focal tracer uptake was demonstrated in either gastric or extragastric lesions or in involved lymph nodes, irrespective of histologic grading. In three patients the scan showed a false negative result with respect to the MALT lesions but showed focal tracer uptake indicating tumor spread, which, however, was ruled out by further follow-up and biopsy, respectively, and was thus rated false positive. Due to these results, the study was discontinued prematurely after the first ten patients.

CONCLUSIONS

These discouraging results indicated that WB-FDG-PET is not useful for staging and follow-up of MALT-type lymphoma, and should therefore not be included in the clinical decision making process.

Authors+Show Affiliations

Department of Nuclear Medicine, University of Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10586335

Citation

Hoffmann, M, et al. "Positron Emission Tomography With fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) Does Not Visualize Extranodal B-cell Lymphoma of the Mucosa-associated Lymphoid Tissue (MALT)-type." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 10, no. 10, 1999, pp. 1185-9.
Hoffmann M, Kletter K, Diemling M, et al. Positron emission tomography with fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) does not visualize extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)-type. Ann Oncol. 1999;10(10):1185-9.
Hoffmann, M., Kletter, K., Diemling, M., Becherer, A., Pfeffel, F., Petkov, V., Chott, A., & Raderer, M. (1999). Positron emission tomography with fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) does not visualize extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)-type. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 10(10), 1185-9.
Hoffmann M, et al. Positron Emission Tomography With fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) Does Not Visualize Extranodal B-cell Lymphoma of the Mucosa-associated Lymphoid Tissue (MALT)-type. Ann Oncol. 1999;10(10):1185-9. PubMed PMID: 10586335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Positron emission tomography with fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) does not visualize extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT)-type. AU - Hoffmann,M, AU - Kletter,K, AU - Diemling,M, AU - Becherer,A, AU - Pfeffel,F, AU - Petkov,V, AU - Chott,A, AU - Raderer,M, PY - 1999/12/10/pubmed PY - 1999/12/10/medline PY - 1999/12/10/entrez SP - 1185 EP - 9 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 10 IS - 10 N2 - BACKGROUND: On the basis of promising data on the use of fluorine-18-2-fluoro-2-deoxy-D-glucose (F18-FDG) whole body positron emission tomography (WB-FDG-PET) in the staging of patients with lymphoma, we initiated a pilot series to evaluate the role of WB-FDG-PET in the staging of extranodal B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type. PATIENTS AND METHODS: We examined ten consecutive patients with histologically-verified MALT-type lymphomas of various origin before initiation of therapy. Nine patients had low-grade lymphomas (five cases of gastric lymphoma, two patients with lymphoma arising in the lung, one parotid and one lacrimal gland lymphoma), while one patient had a high-grade gastric lymphoma arising from a low-grade background. Two patients had stage EI, seven had stage EII disease, and one presented with stage EIII. WB-FDG-PET scans were performed 40 min following the injection of 300-380 MBq of F18-FDG. The PET scans were correlated with extensive conventional staging including ophthalmologic investigation, otolaryngologic examination, gastroscopy, endosonography, enteroclysis, colonoscopy, CT of thorax and abdomen, and bone marrow biopsy. RESULTS: WB-FDG-PET documented no lymphoma in any of the 10 patients studied, as no focal tracer uptake was demonstrated in either gastric or extragastric lesions or in involved lymph nodes, irrespective of histologic grading. In three patients the scan showed a false negative result with respect to the MALT lesions but showed focal tracer uptake indicating tumor spread, which, however, was ruled out by further follow-up and biopsy, respectively, and was thus rated false positive. Due to these results, the study was discontinued prematurely after the first ten patients. CONCLUSIONS: These discouraging results indicated that WB-FDG-PET is not useful for staging and follow-up of MALT-type lymphoma, and should therefore not be included in the clinical decision making process. SN - 0923-7534 UR - https://www.unboundmedicine.com/medline/citation/10586335/Positron_emission_tomography_with_fluorine_18_2_fluoro_2_deoxy_D_glucose__F18_FDG__does_not_visualize_extranodal_B_cell_lymphoma_of_the_mucosa_associated_lymphoid_tissue__MALT__type_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1023/a:1008312726163 DB - PRIME DP - Unbound Medicine ER -