Antibody responses to the outer membrane protein P6 of non-typeable Haemophilus influenzae and pneumococcal capsular polysaccharides in otitis-prone children.Acta Otolaryngol. 1999; 119(6):703-7.AO
Abstract
Acute otitis media (AOM) is a common infectious disease in children. Some children experience recurrent episodes of AOM. Recent investigations demonstrate antigen-specific immunological deficiencies in children prone to AOM. In the present study, the immune responses to non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (S. pneumoniae) were further investigated in otitis-prone children and normal children. Forty-eight percent of otitis-prone children exhibited reduced IgG2 levels to S. pneumoniae and 55% exhibited reduced IgG levels to NTHi. These data suggest that otitis proneness appears to be related to numerous immunological derangements. Pathogen-specific antibodies are a reliable measure of otitis proneness.
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MeSH
Acute DiseaseAntibodies, BacterialBacterial CapsulesBacterial Outer Membrane ProteinsChi-Square DistributionChild, PreschoolDisease SusceptibilityFemaleHaemophilus VaccinesHaemophilus influenzaeHumansImmunoglobulin GInfantMaleMolecular WeightOtitis MediaPolysaccharides, BacterialStreptococcus pneumoniae
Pub Type(s)
Comparative Study
Journal Article
Language
eng
PubMed ID
10587005
Citation
Hotomi, M, et al. "Antibody Responses to the Outer Membrane Protein P6 of Non-typeable Haemophilus Influenzae and Pneumococcal Capsular Polysaccharides in Otitis-prone Children." Acta Oto-laryngologica, vol. 119, no. 6, 1999, pp. 703-7.
Hotomi M, Yamanaka N, Saito T, et al. Antibody responses to the outer membrane protein P6 of non-typeable Haemophilus influenzae and pneumococcal capsular polysaccharides in otitis-prone children. Acta Otolaryngol. 1999;119(6):703-7.
Hotomi, M., Yamanaka, N., Saito, T., Shimada, J., Suzumoto, M., Suetake, M., & Faden, H. (1999). Antibody responses to the outer membrane protein P6 of non-typeable Haemophilus influenzae and pneumococcal capsular polysaccharides in otitis-prone children. Acta Oto-laryngologica, 119(6), 703-7.
Hotomi M, et al. Antibody Responses to the Outer Membrane Protein P6 of Non-typeable Haemophilus Influenzae and Pneumococcal Capsular Polysaccharides in Otitis-prone Children. Acta Otolaryngol. 1999;119(6):703-7. PubMed PMID: 10587005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Antibody responses to the outer membrane protein P6 of non-typeable Haemophilus influenzae and pneumococcal capsular polysaccharides in otitis-prone children.
AU - Hotomi,M,
AU - Yamanaka,N,
AU - Saito,T,
AU - Shimada,J,
AU - Suzumoto,M,
AU - Suetake,M,
AU - Faden,H,
PY - 1999/12/10/pubmed
PY - 1999/12/10/medline
PY - 1999/12/10/entrez
SP - 703
EP - 7
JF - Acta oto-laryngologica
JO - Acta Otolaryngol
VL - 119
IS - 6
N2 - Acute otitis media (AOM) is a common infectious disease in children. Some children experience recurrent episodes of AOM. Recent investigations demonstrate antigen-specific immunological deficiencies in children prone to AOM. In the present study, the immune responses to non-typeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (S. pneumoniae) were further investigated in otitis-prone children and normal children. Forty-eight percent of otitis-prone children exhibited reduced IgG2 levels to S. pneumoniae and 55% exhibited reduced IgG levels to NTHi. These data suggest that otitis proneness appears to be related to numerous immunological derangements. Pathogen-specific antibodies are a reliable measure of otitis proneness.
SN - 0001-6489
UR - https://www.unboundmedicine.com/medline/citation/10587005/Antibody_responses_to_the_outer_membrane_protein_P6_of_non_typeable_Haemophilus_influenzae_and_pneumococcal_capsular_polysaccharides_in_otitis_prone_children_
L2 - https://www.tandfonline.com/doi/full/10.1080/00016489950180667
DB - PRIME
DP - Unbound Medicine
ER -
