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Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight.
J Endocrinol 1999; 163(3):R11-4JE

Abstract

Leptin mRNA was measured in adipose tissue of fetal sheep by reverse transcription polymerase chain reaction (RTPCR). Abundance of leptin mRNA relative to beta-actin mRNA in fetal perirenal adipose tissue increased (P<0.02) with gestation, being higher at 144 d (0.73+/-0. 10, n=5) than at 90-91 d (0.40 +/- 0.08, n=6) or 125 d (0.40 +/- 0. 04, n=5) gestation (term approximately 147- 150 d). There was a positive relationship between relative abundance of leptin mRNA (y) and fetal body weight (x) between 90 and 144 d gestation (r(2) =0.27, P<0.01). The slope of the linear dependence of leptin mRNA on fetal weight was 15-fold greater (P<0.001) at 90-91d (y = 2.81x - 1.1, n=6, r(2) =0.71, P<0.025) than between 125-144 d gestation (y = 0.195x - 0.15, n=16, r(2) =0.39, P<0.01). Thus the leptin synthetic capacity of fetal adipose tissue appears to increase in late gestation but this is accompanied by constraint of its sensitivity to fetal body weight. We hypothesise that leptin synthesis in fetal adipose tissue is related to fetal nutrient supply and growth rate.

Authors+Show Affiliations

Department of Physiology, University of Adelaide, Adelaide 5005, Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Corrected and Republished Article
Journal Article

Language

eng

PubMed ID

10588830

Citation

Yuen, B S., et al. "Abundance of Leptin mRNA in Fetal Adipose Tissue Is Related to Fetal Body Weight." The Journal of Endocrinology, vol. 163, no. 3, 1999, pp. R11-4.
Yuen BS, McMillen IC, Symonds ME, et al. Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight. J Endocrinol. 1999;163(3):R11-4.
Yuen, B. S., McMillen, I. C., Symonds, M. E., & Owens, P. C. (1999). Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight. The Journal of Endocrinology, 163(3), pp. R11-4.
Yuen BS, et al. Abundance of Leptin mRNA in Fetal Adipose Tissue Is Related to Fetal Body Weight. J Endocrinol. 1999;163(3):R11-4. PubMed PMID: 10588830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight. AU - Yuen,B S, AU - McMillen,I C, AU - Symonds,M E, AU - Owens,P C, PY - 1999/12/10/pubmed PY - 2000/2/19/medline PY - 1999/12/10/entrez SP - R11 EP - 4 JF - The Journal of endocrinology JO - J. Endocrinol. VL - 163 IS - 3 N2 - Leptin mRNA was measured in adipose tissue of fetal sheep by reverse transcription polymerase chain reaction (RTPCR). Abundance of leptin mRNA relative to beta-actin mRNA in fetal perirenal adipose tissue increased (P<0.02) with gestation, being higher at 144 d (0.73+/-0. 10, n=5) than at 90-91 d (0.40 +/- 0.08, n=6) or 125 d (0.40 +/- 0. 04, n=5) gestation (term approximately 147- 150 d). There was a positive relationship between relative abundance of leptin mRNA (y) and fetal body weight (x) between 90 and 144 d gestation (r(2) =0.27, P<0.01). The slope of the linear dependence of leptin mRNA on fetal weight was 15-fold greater (P<0.001) at 90-91d (y = 2.81x - 1.1, n=6, r(2) =0.71, P<0.025) than between 125-144 d gestation (y = 0.195x - 0.15, n=16, r(2) =0.39, P<0.01). Thus the leptin synthetic capacity of fetal adipose tissue appears to increase in late gestation but this is accompanied by constraint of its sensitivity to fetal body weight. We hypothesise that leptin synthesis in fetal adipose tissue is related to fetal nutrient supply and growth rate. SN - 0022-0795 UR - https://www.unboundmedicine.com/medline/citation/10588830/Abundance_of_leptin_mRNA_in_fetal_adipose_tissue_is_related_to_fetal_body_weight_ L2 - https://joe.bioscientifica.com/doi/10.1677/joe.0.163r011 DB - PRIME DP - Unbound Medicine ER -