Tags

Type your tag names separated by a space and hit enter

Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects.
J Allergy Clin Immunol. 1999 Dec; 104(6):1273-9.JA

Abstract

BACKGROUND

Although allergens have been implicated as aggravating factors in atopic dermatitis (AD), there is little epidemiologic data on the significance of specific IgE.

OBJECTIVE

We sought to compare sensitization to dust mite and fungi between patients with AD and asthmatic and nonasthmatic control subjects.

METHODS

Total IgE and specific IgE to Dermatophagoides pteronyssinus, Alternaria alternata, Aspergillus fumigatus, Candida albicans, Malassezia furfur, and Trichophyton rubrum were measured in 73 patients with moderate to severe AD. Total IgE and IgE specific for D pteronyssinus, A alternata, and M furfur were also measured in sera from 156 asthmatic and 212 nonasthmatic control subjects.

RESULTS

Positive correlations were found between total IgE and IgE antibodies specific for each of the antigens. IgE specific for M furfur was observed more frequently in adults compared with children with AD (P <.01). AD sera had higher levels of total IgE and a higher prevalence of positive sera to D pteronyssinus (95% vs 42% and 17% for subjects with AD, asthmatic subjects, and nonasthmatic subjects, respectively), M furfur (53% vs 1% and 0.5%), and A alternata (49% vs 29% and 18%). Among the sera from subjects allergic to mites, the contribution of IgE specific for D pteronyssinus to the total IgE levels was similar regardless of the clinical status.

CONCLUSIONS

Our results demonstrate that moderate-to-severe AD is strongly associated with sensitization to dust mite andM furfur (odds ratios, 45.6 and 132 vs pooled control sera). These results suggest that both environmental allergens and colonizing fungi contribute to the severity of disease, which is consistent with the view that mite avoidance and antifungal treatment can be beneficial in the treatment of these patients.

Authors+Show Affiliations

Asthma and Allergic Disease Center, Departments of Internal Medicine and Dermatology, University of Virginia, Charlottesville, VA 22908, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10589012

Citation

Scalabrin, D M., et al. "Use of Specific IgE in Assessing the Relevance of Fungal and Dust Mite Allergens to Atopic Dermatitis: a Comparison With Asthmatic and Nonasthmatic Control Subjects." The Journal of Allergy and Clinical Immunology, vol. 104, no. 6, 1999, pp. 1273-9.
Scalabrin DM, Bavbek S, Perzanowski MS, et al. Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. J Allergy Clin Immunol. 1999;104(6):1273-9.
Scalabrin, D. M., Bavbek, S., Perzanowski, M. S., Wilson, B. B., Platts-Mills, T. A., & Wheatley, L. M. (1999). Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. The Journal of Allergy and Clinical Immunology, 104(6), 1273-9.
Scalabrin DM, et al. Use of Specific IgE in Assessing the Relevance of Fungal and Dust Mite Allergens to Atopic Dermatitis: a Comparison With Asthmatic and Nonasthmatic Control Subjects. J Allergy Clin Immunol. 1999;104(6):1273-9. PubMed PMID: 10589012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. AU - Scalabrin,D M, AU - Bavbek,S, AU - Perzanowski,M S, AU - Wilson,B B, AU - Platts-Mills,T A, AU - Wheatley,L M, PY - 1999/12/10/pubmed PY - 1999/12/10/medline PY - 1999/12/10/entrez SP - 1273 EP - 9 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 104 IS - 6 N2 - BACKGROUND: Although allergens have been implicated as aggravating factors in atopic dermatitis (AD), there is little epidemiologic data on the significance of specific IgE. OBJECTIVE: We sought to compare sensitization to dust mite and fungi between patients with AD and asthmatic and nonasthmatic control subjects. METHODS: Total IgE and specific IgE to Dermatophagoides pteronyssinus, Alternaria alternata, Aspergillus fumigatus, Candida albicans, Malassezia furfur, and Trichophyton rubrum were measured in 73 patients with moderate to severe AD. Total IgE and IgE specific for D pteronyssinus, A alternata, and M furfur were also measured in sera from 156 asthmatic and 212 nonasthmatic control subjects. RESULTS: Positive correlations were found between total IgE and IgE antibodies specific for each of the antigens. IgE specific for M furfur was observed more frequently in adults compared with children with AD (P <.01). AD sera had higher levels of total IgE and a higher prevalence of positive sera to D pteronyssinus (95% vs 42% and 17% for subjects with AD, asthmatic subjects, and nonasthmatic subjects, respectively), M furfur (53% vs 1% and 0.5%), and A alternata (49% vs 29% and 18%). Among the sera from subjects allergic to mites, the contribution of IgE specific for D pteronyssinus to the total IgE levels was similar regardless of the clinical status. CONCLUSIONS: Our results demonstrate that moderate-to-severe AD is strongly associated with sensitization to dust mite andM furfur (odds ratios, 45.6 and 132 vs pooled control sera). These results suggest that both environmental allergens and colonizing fungi contribute to the severity of disease, which is consistent with the view that mite avoidance and antifungal treatment can be beneficial in the treatment of these patients. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/10589012/Use_of_specific_IgE_in_assessing_the_relevance_of_fungal_and_dust_mite_allergens_to_atopic_dermatitis:_a_comparison_with_asthmatic_and_nonasthmatic_control_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(99)70024-2 DB - PRIME DP - Unbound Medicine ER -