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Beneficial effect of intranasal desmopressin for men with benign prostatic hyperplasia and nocturia: preliminary results.
Tech Urol. 1999 Dec; 5(4):191-4.TU

Abstract

The aim of this study was to determine the efficacy of intranasal desmopressin in the treatment of nocturnal polyuria in men with benign prostatic hyperplasia (BPH). Twelve men with BPH were treated with intranasal desmopressin at bedtime for nocturnal polyuria. All patients underwent video-urodynamic evaluation. The number of nocturia episodes was the dependent variable. Exclusion criteria included nephrolithiasis, active urinary tact infection, and history of myocardial infarction, congestive heart failure, and angina. Ten of 12 patients improved with the intranasal desmopressin therapy. Nocturia episodes decreased from a median of 3.6 +/- 0.5 episodes/night before treatment to 1.8 +/- 1.1 episodes/night 3 months after therapy (p = .01). The American Urological Association symptom index decreased from 19 +/- 6 before treatment to 12 +/- 6 after therapy (p = .02). Hyponatremia did not occur. We conclude that intranasal desmopressin is a promising therapy for nocturnal polyuria in selected BPH patients.

Authors+Show Affiliations

Division of Urologic Surgery, University of Pittsburgh, School of Medicine, Pennsylvania, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10591256

Citation

Chancellor, M B., et al. "Beneficial Effect of Intranasal Desmopressin for Men With Benign Prostatic Hyperplasia and Nocturia: Preliminary Results." Techniques in Urology, vol. 5, no. 4, 1999, pp. 191-4.
Chancellor MB, Atan A, Rivas DA, et al. Beneficial effect of intranasal desmopressin for men with benign prostatic hyperplasia and nocturia: preliminary results. Tech Urol. 1999;5(4):191-4.
Chancellor, M. B., Atan, A., Rivas, D. A., Watanabe, T., Tai, H. L., & Kumon, H. (1999). Beneficial effect of intranasal desmopressin for men with benign prostatic hyperplasia and nocturia: preliminary results. Techniques in Urology, 5(4), 191-4.
Chancellor MB, et al. Beneficial Effect of Intranasal Desmopressin for Men With Benign Prostatic Hyperplasia and Nocturia: Preliminary Results. Tech Urol. 1999;5(4):191-4. PubMed PMID: 10591256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effect of intranasal desmopressin for men with benign prostatic hyperplasia and nocturia: preliminary results. AU - Chancellor,M B, AU - Atan,A, AU - Rivas,D A, AU - Watanabe,T, AU - Tai,H L, AU - Kumon,H, PY - 1999/12/11/pubmed PY - 1999/12/11/medline PY - 1999/12/11/entrez SP - 191 EP - 4 JF - Techniques in urology JO - Tech Urol VL - 5 IS - 4 N2 - The aim of this study was to determine the efficacy of intranasal desmopressin in the treatment of nocturnal polyuria in men with benign prostatic hyperplasia (BPH). Twelve men with BPH were treated with intranasal desmopressin at bedtime for nocturnal polyuria. All patients underwent video-urodynamic evaluation. The number of nocturia episodes was the dependent variable. Exclusion criteria included nephrolithiasis, active urinary tact infection, and history of myocardial infarction, congestive heart failure, and angina. Ten of 12 patients improved with the intranasal desmopressin therapy. Nocturia episodes decreased from a median of 3.6 +/- 0.5 episodes/night before treatment to 1.8 +/- 1.1 episodes/night 3 months after therapy (p = .01). The American Urological Association symptom index decreased from 19 +/- 6 before treatment to 12 +/- 6 after therapy (p = .02). Hyponatremia did not occur. We conclude that intranasal desmopressin is a promising therapy for nocturnal polyuria in selected BPH patients. SN - 1079-3259 UR - https://www.unboundmedicine.com/medline/citation/10591256/Beneficial_effect_of_intranasal_desmopressin_for_men_with_benign_prostatic_hyperplasia_and_nocturia:_preliminary_results_ L2 - http://www.diseaseinfosearch.org/result/9668 DB - PRIME DP - Unbound Medicine ER -