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Increase in serum concentrations of thyroxine-binding globulin and of cortisol-binding globulin after the induction of normal thyroid function in previously hyperthyroid patients.
Thyroid. 1999 Nov; 9(11):1085-7.T

Abstract

Serum concentrations of thyroxine-binding globulin (TBG) were determined in 36 female patients with hyperthyroidism due to either Graves' disease (n = 33), or autonomous thyroid adenomas (n = 3). After the induction of euthyroidism by antithyroid drugs, serum concentrations of TBG rose from 13.7 +/- 2.4 ng/mL to 17.1 +/- 2.8 ng/mL (p < 0.001) whereas those of sex hormone-binding globulin (SHBG) fell from 142.2 +/- 66.4 nmol/L to 53.6 +/- 21.8 nmol/L (p < 0.001). Serum concentrations of cortisol-binding globulin (CBG) rose to 42.9 +/- 10.3 microg/mL (basal: 36.8 +/- 9.4 microg/mL; p < 0.001) but serum concentrations of total and of free cortisol remained unchanged. Thus, thyroid hormones exert different effects on the production of various carrier proteins in vivo. Whereas they stimulate the production of SHBG, they suppress the level of CBG and of their own carrier protein, TBG.

Authors+Show Affiliations

Department of Internal Medicine III, University of Vienna, Austria. h.vierhapper@akh-wien.ac.atNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10595456

Citation

Vierhapper, H, et al. "Increase in Serum Concentrations of Thyroxine-binding Globulin and of Cortisol-binding Globulin After the Induction of Normal Thyroid Function in Previously Hyperthyroid Patients." Thyroid : Official Journal of the American Thyroid Association, vol. 9, no. 11, 1999, pp. 1085-7.
Vierhapper H, Nowotny P, Waldhäusl W. Increase in serum concentrations of thyroxine-binding globulin and of cortisol-binding globulin after the induction of normal thyroid function in previously hyperthyroid patients. Thyroid. 1999;9(11):1085-7.
Vierhapper, H., Nowotny, P., & Waldhäusl, W. (1999). Increase in serum concentrations of thyroxine-binding globulin and of cortisol-binding globulin after the induction of normal thyroid function in previously hyperthyroid patients. Thyroid : Official Journal of the American Thyroid Association, 9(11), 1085-7.
Vierhapper H, Nowotny P, Waldhäusl W. Increase in Serum Concentrations of Thyroxine-binding Globulin and of Cortisol-binding Globulin After the Induction of Normal Thyroid Function in Previously Hyperthyroid Patients. Thyroid. 1999;9(11):1085-7. PubMed PMID: 10595456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase in serum concentrations of thyroxine-binding globulin and of cortisol-binding globulin after the induction of normal thyroid function in previously hyperthyroid patients. AU - Vierhapper,H, AU - Nowotny,P, AU - Waldhäusl,W, PY - 1999/12/14/pubmed PY - 1999/12/14/medline PY - 1999/12/14/entrez SP - 1085 EP - 7 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 9 IS - 11 N2 - Serum concentrations of thyroxine-binding globulin (TBG) were determined in 36 female patients with hyperthyroidism due to either Graves' disease (n = 33), or autonomous thyroid adenomas (n = 3). After the induction of euthyroidism by antithyroid drugs, serum concentrations of TBG rose from 13.7 +/- 2.4 ng/mL to 17.1 +/- 2.8 ng/mL (p < 0.001) whereas those of sex hormone-binding globulin (SHBG) fell from 142.2 +/- 66.4 nmol/L to 53.6 +/- 21.8 nmol/L (p < 0.001). Serum concentrations of cortisol-binding globulin (CBG) rose to 42.9 +/- 10.3 microg/mL (basal: 36.8 +/- 9.4 microg/mL; p < 0.001) but serum concentrations of total and of free cortisol remained unchanged. Thus, thyroid hormones exert different effects on the production of various carrier proteins in vivo. Whereas they stimulate the production of SHBG, they suppress the level of CBG and of their own carrier protein, TBG. SN - 1050-7256 UR - https://www.unboundmedicine.com/medline/citation/10595456/Increase_in_serum_concentrations_of_thyroxine_binding_globulin_and_of_cortisol_binding_globulin_after_the_induction_of_normal_thyroid_function_in_previously_hyperthyroid_patients_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.1999.9.1085?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -