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Pituitary apoplexy probably due to TRH and GnRH stimulation tests in a patient with acromegaly.
J Endocrinol Invest. 1999 Oct; 22(9):698-700.JE

Abstract

Pituitary apoplexy is the most serious and life-threatening complication of pituitary adenomas. Most of the cases occur spontaneously but it may occur also after a number of events such as the pituitary stimulation tests. We report a case of acromegaly due to a giant pituitary adenoma in which pituitary apoplexy developed 88 hours after TRH/GnRH stimulation test. The patient had severe headaches, nausea, vomiting, visual disturbance and mental alteration and the computed tomography (CT) scans revealed intratumoral and intraventricular bleeding. The pituitary mass was removed by transsphenoidal approach. The patient developed pneumonia and died on the 9th postoperative day. Pituitary apoplexy was confirmed at surgery and on histological examination. Immunohistochemical staining was positive for GH and PRL. This case indicates that pituitary apoplexy may develop several days after TRH/GnRH stimulation test.

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Authors+Show Affiliations

Dökmetaş HS
Department of Endocrinology, Erciyes University, Medical School, Kayseri, Turkey.
Selçuklu A
No affiliation info available
Colak R
No affiliation info available
Unlühizarci K
No affiliation info available
Bayram F
No affiliation info available
Keleştimur F
No affiliation info available

MeSH

AcromegalyAdenomaAdultFatal OutcomeFemaleGonadotropin-Releasing HormoneHumansPituitary ApoplexyPituitary NeoplasmsThyrotropin-Releasing Hormone

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10595834

Citation

Dökmetaş, H S., et al. "Pituitary Apoplexy Probably Due to TRH and GnRH Stimulation Tests in a Patient With Acromegaly." Journal of Endocrinological Investigation, vol. 22, no. 9, 1999, pp. 698-700.
Dökmetaş HS, Selçuklu A, Colak R, et al. Pituitary apoplexy probably due to TRH and GnRH stimulation tests in a patient with acromegaly. J Endocrinol Invest. 1999;22(9):698-700.
Dökmetaş, H. S., Selçuklu, A., Colak, R., Unlühizarci, K., Bayram, F., & Keleştimur, F. (1999). Pituitary apoplexy probably due to TRH and GnRH stimulation tests in a patient with acromegaly. Journal of Endocrinological Investigation, 22(9), 698-700.
Dökmetaş HS, et al. Pituitary Apoplexy Probably Due to TRH and GnRH Stimulation Tests in a Patient With Acromegaly. J Endocrinol Invest. 1999;22(9):698-700. PubMed PMID: 10595834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pituitary apoplexy probably due to TRH and GnRH stimulation tests in a patient with acromegaly. AU - Dökmetaş,H S, AU - Selçuklu,A, AU - Colak,R, AU - Unlühizarci,K, AU - Bayram,F, AU - Keleştimur,F, PY - 1999/12/14/pubmed PY - 1999/12/14/medline PY - 1999/12/14/entrez SP - 698 EP - 700 JF - Journal of endocrinological investigation JO - J Endocrinol Invest VL - 22 IS - 9 N2 - Pituitary apoplexy is the most serious and life-threatening complication of pituitary adenomas. Most of the cases occur spontaneously but it may occur also after a number of events such as the pituitary stimulation tests. We report a case of acromegaly due to a giant pituitary adenoma in which pituitary apoplexy developed 88 hours after TRH/GnRH stimulation test. The patient had severe headaches, nausea, vomiting, visual disturbance and mental alteration and the computed tomography (CT) scans revealed intratumoral and intraventricular bleeding. The pituitary mass was removed by transsphenoidal approach. The patient developed pneumonia and died on the 9th postoperative day. Pituitary apoplexy was confirmed at surgery and on histological examination. Immunohistochemical staining was positive for GH and PRL. This case indicates that pituitary apoplexy may develop several days after TRH/GnRH stimulation test. SN - 0391-4097 UR - https://www.unboundmedicine.com/medline/citation/10595834/Pituitary_apoplexy_probably_due_to_TRH_and_GnRH_stimulation_tests_in_a_patient_with_acromegaly_ L2 - https://link.springer.com/article/10.1007/BF03343632 DB - PRIME DP - Unbound Medicine ER -