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Excess mortality related to alcohol and smoking among hospital-treated patients with psoriasis.
Arch Dermatol. 1999 Dec; 135(12):1490-3.AD

Abstract

BACKGROUND

Psoriasis is seen as a disease that does not kill. However, it is associated with alcohol intake and smoking. Thus, there could be excess mortality due to causes related to alcohol intake and smoking among patients with psoriasis.

DESIGN

A cohort was identified from the nationwide Hospital Discharge Register from January 1, 1973, through December 31, 1984, and mortality was followed up for 22 years by linkage with the Cause-of-Death Register, from January 1, 1973, through December 31, 1995.

PATIENTS

A cohort of 3132 men and 2555 women admitted to inpatient treatment with psoriasis as the principal diagnosis.

MAIN OUTCOME MEASURES

Date and underlying cause of death.

RESULTS

We observed 1918 deaths in contrast to the 1211 deaths expected on the basis of the national mortality rates. The all-cause standardized mortality ratio (SMR) for men was 1.62 (95% confidence interval [CI], 1.52-1.71); for women, 1.54 (95% CI, 1.43-1.64). Among men, the highest SMRs were found for alcohol psychosis (8.91 [95% CI, 2.89-20.70]) and liver disease, ie, cirrhosis, fatty liver, and hepatitis (6.98 [95% CI, 5.34-8.96]). Among women, the highest SMR was found for liver disease (5.06 [95% CI, 2.70-8.65]). Excess mortality was high for all causes of death directly related to alcohol; the SMR for men was 4.46 (95% CI, 3.60-5.45); for women, 5.60 (95% CI, 2.98-8.65).

CONCLUSIONS

Patients with moderate to severe psoriasis are at increased risk for death. Alcohol is a major cause for this excess mortality.

Authors+Show Affiliations

Järvenpää Addiction Hospital, Helsinki, Finland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10606054

Citation

Poikolainen, K, et al. "Excess Mortality Related to Alcohol and Smoking Among Hospital-treated Patients With Psoriasis." Archives of Dermatology, vol. 135, no. 12, 1999, pp. 1490-3.
Poikolainen K, Karvonen J, Pukkala E. Excess mortality related to alcohol and smoking among hospital-treated patients with psoriasis. Arch Dermatol. 1999;135(12):1490-3.
Poikolainen, K., Karvonen, J., & Pukkala, E. (1999). Excess mortality related to alcohol and smoking among hospital-treated patients with psoriasis. Archives of Dermatology, 135(12), 1490-3.
Poikolainen K, Karvonen J, Pukkala E. Excess Mortality Related to Alcohol and Smoking Among Hospital-treated Patients With Psoriasis. Arch Dermatol. 1999;135(12):1490-3. PubMed PMID: 10606054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excess mortality related to alcohol and smoking among hospital-treated patients with psoriasis. AU - Poikolainen,K, AU - Karvonen,J, AU - Pukkala,E, PY - 1999/12/22/pubmed PY - 1999/12/22/medline PY - 1999/12/22/entrez SP - 1490 EP - 3 JF - Archives of dermatology JO - Arch Dermatol VL - 135 IS - 12 N2 - BACKGROUND: Psoriasis is seen as a disease that does not kill. However, it is associated with alcohol intake and smoking. Thus, there could be excess mortality due to causes related to alcohol intake and smoking among patients with psoriasis. DESIGN: A cohort was identified from the nationwide Hospital Discharge Register from January 1, 1973, through December 31, 1984, and mortality was followed up for 22 years by linkage with the Cause-of-Death Register, from January 1, 1973, through December 31, 1995. PATIENTS: A cohort of 3132 men and 2555 women admitted to inpatient treatment with psoriasis as the principal diagnosis. MAIN OUTCOME MEASURES: Date and underlying cause of death. RESULTS: We observed 1918 deaths in contrast to the 1211 deaths expected on the basis of the national mortality rates. The all-cause standardized mortality ratio (SMR) for men was 1.62 (95% confidence interval [CI], 1.52-1.71); for women, 1.54 (95% CI, 1.43-1.64). Among men, the highest SMRs were found for alcohol psychosis (8.91 [95% CI, 2.89-20.70]) and liver disease, ie, cirrhosis, fatty liver, and hepatitis (6.98 [95% CI, 5.34-8.96]). Among women, the highest SMR was found for liver disease (5.06 [95% CI, 2.70-8.65]). Excess mortality was high for all causes of death directly related to alcohol; the SMR for men was 4.46 (95% CI, 3.60-5.45); for women, 5.60 (95% CI, 2.98-8.65). CONCLUSIONS: Patients with moderate to severe psoriasis are at increased risk for death. Alcohol is a major cause for this excess mortality. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/10606054/Excess_mortality_related_to_alcohol_and_smoking_among_hospital_treated_patients_with_psoriasis_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/135/pg/1490 DB - PRIME DP - Unbound Medicine ER -