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Association between infections with CagA-positive or -negative strains of Helicobacter pylori and risk for gastric cancer in young adults. Research Group on Prevention of Gastric Carcinoma Among Young Adults.
Am J Gastroenterol 1999; 94(12):3455-9AJ

Abstract

OBJECTIVE

We assessed the association between infection with CagA-positive and -negative Helicobacter pylori and the risk of gastric cancer in young adults.

METHODS

CagA IgG antibodies were measured in sera of subjects participating in a case-control study in Japan. The study subjects were 103 gastric cancer patients <40 yr of age, 100 inpatients with benign diseases, and 101 screenees younger than age 43 yr.

RESULTS

Compared with the H. pylori-negative/CagA-negative (H. pylori-/CagA-) group, both the H. pylori-positive/CagA-negative (H. pylori+/CagA-) group and the H. pylori-positive/CagA-positive (H. pylori+/CagA+) groups showed elevated odds ratios for intestinal-type, diffuse-type, early, advanced, proximal, and distal gastric cancers. All the relationships were significant except for the H. pylori+/CagA- group in relation to proximal cancer. The overall odds ratios (95% confidence intervals) for gastric cancer in the H. pylori+/CagA- and the H. pylori+/CagA+ groups were 15.0 (6.4, 35.2) and 14.6 (6.7, 31.9), respectively. Between these two groups, no significant difference was observed in risks for intestinal-type, diffuse-type, early, advanced, proximal, or distal gastric cancer.

CONCLUSIONS

In those <40 yr of age, it is concluded that both CagA-positive and CagA-negative H. pylori infections are related to risks of intestinal-type, diffuse-type, early, advanced, and distal gastric cancers.

Authors+Show Affiliations

Department of Epidemiology and Environmental Health, Juntendo University School of Medicine, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10606302

Citation

Kikuchi, S, et al. "Association Between Infections With CagA-positive or -negative Strains of Helicobacter Pylori and Risk for Gastric Cancer in Young Adults. Research Group On Prevention of Gastric Carcinoma Among Young Adults." The American Journal of Gastroenterology, vol. 94, no. 12, 1999, pp. 3455-9.
Kikuchi S, Crabtree JE, Forman D, et al. Association between infections with CagA-positive or -negative strains of Helicobacter pylori and risk for gastric cancer in young adults. Research Group on Prevention of Gastric Carcinoma Among Young Adults. Am J Gastroenterol. 1999;94(12):3455-9.
Kikuchi, S., Crabtree, J. E., Forman, D., & Kurosawa, M. (1999). Association between infections with CagA-positive or -negative strains of Helicobacter pylori and risk for gastric cancer in young adults. Research Group on Prevention of Gastric Carcinoma Among Young Adults. The American Journal of Gastroenterology, 94(12), pp. 3455-9.
Kikuchi S, et al. Association Between Infections With CagA-positive or -negative Strains of Helicobacter Pylori and Risk for Gastric Cancer in Young Adults. Research Group On Prevention of Gastric Carcinoma Among Young Adults. Am J Gastroenterol. 1999;94(12):3455-9. PubMed PMID: 10606302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between infections with CagA-positive or -negative strains of Helicobacter pylori and risk for gastric cancer in young adults. Research Group on Prevention of Gastric Carcinoma Among Young Adults. AU - Kikuchi,S, AU - Crabtree,J E, AU - Forman,D, AU - Kurosawa,M, PY - 1999/12/22/pubmed PY - 1999/12/22/medline PY - 1999/12/22/entrez SP - 3455 EP - 9 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 94 IS - 12 N2 - OBJECTIVE: We assessed the association between infection with CagA-positive and -negative Helicobacter pylori and the risk of gastric cancer in young adults. METHODS: CagA IgG antibodies were measured in sera of subjects participating in a case-control study in Japan. The study subjects were 103 gastric cancer patients <40 yr of age, 100 inpatients with benign diseases, and 101 screenees younger than age 43 yr. RESULTS: Compared with the H. pylori-negative/CagA-negative (H. pylori-/CagA-) group, both the H. pylori-positive/CagA-negative (H. pylori+/CagA-) group and the H. pylori-positive/CagA-positive (H. pylori+/CagA+) groups showed elevated odds ratios for intestinal-type, diffuse-type, early, advanced, proximal, and distal gastric cancers. All the relationships were significant except for the H. pylori+/CagA- group in relation to proximal cancer. The overall odds ratios (95% confidence intervals) for gastric cancer in the H. pylori+/CagA- and the H. pylori+/CagA+ groups were 15.0 (6.4, 35.2) and 14.6 (6.7, 31.9), respectively. Between these two groups, no significant difference was observed in risks for intestinal-type, diffuse-type, early, advanced, proximal, or distal gastric cancer. CONCLUSIONS: In those <40 yr of age, it is concluded that both CagA-positive and CagA-negative H. pylori infections are related to risks of intestinal-type, diffuse-type, early, advanced, and distal gastric cancers. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10606302/Association_between_infections_with_CagA_positive_or__negative_strains_of_Helicobacter_pylori_and_risk_for_gastric_cancer_in_young_adults__Research_Group_on_Prevention_of_Gastric_Carcinoma_Among_Young_Adults_ L2 - http://Insights.ovid.com/pubmed?pmid=10606302 DB - PRIME DP - Unbound Medicine ER -