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Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation.
Clin Exp Allergy. 2000 Jan; 30(1):71-8.CE

Abstract

BACKGROUND

Although airway hyperresponsiveness to inhaled acetaldehyde has been documented in Japanese patients with asthma, the response to this bronchoconstrictor agent has never been studied in Caucasians.

OBJECTIVES

The objectives of the study were to determine differences in airway responsiveness to acetaldehyde between asthmatic and healthy subjects, and to examine the relationship between acetaldehyde responsiveness and the variability of peak expiratory flow (PEF).

METHODS

The response to methacholine and acetaldehyde challenges was measured in 81 non-smoking adults (61 asthmatics and 20 normal controls). Subjects recorded PEF morning and evening for 14 days. The response to both bronchoconstrictor agents was measured by the PC20 (provocative concentration required to produce a 20% fall in FEV1). PEF variation was expressed as amplitude percentage mean, and as low percentage best (lowest PEF expressed as a percentage of the best PEF recorded).

RESULTS

The two types of challenge yielded a similarly high level of sensitivity (100% for methacholine and 92% for acetaldehyde) and specificity (90 and 100%, respectively) to distinguish between asthma and controls. Asthmatic subjects were on average 265-fold less sensitive to acetaldehyde than to methacholine. PC20 acetaldehyde correlated weakly but significantly with both indices of PEF variation (amplitude percentage mean: rho = - 0.36, P = 0. 004; low percentage best: rho = 0.42, P = 0.001).

CONCLUSIONS

These results indicate that airway hyperresponsiveness to acetaldehyde is a sensitive and specific indicator for separating asthmatic and normal subjects. Airway responsiveness to methacholine or acetaldehyde and PEF variation are not reflecting the same pathophysiological process in the airways.

Authors+Show Affiliations

Sección de Alergología, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

10606933

Citation

Prieto, L, et al. "Airway Responsiveness to Acetaldehyde in Patients With Asthma: Relationship to Methacholine Responsiveness and Peak Expiratory Flow Variation." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 30, no. 1, 2000, pp. 71-8.
Prieto L, Sánchez-Toril F, Brotons B, et al. Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation. Clin Exp Allergy. 2000;30(1):71-8.
Prieto, L., Sánchez-Toril, F., Brotons, B., Soriano, S., Casañ, R., & Belenguer, J. L. (2000). Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 30(1), 71-8.
Prieto L, et al. Airway Responsiveness to Acetaldehyde in Patients With Asthma: Relationship to Methacholine Responsiveness and Peak Expiratory Flow Variation. Clin Exp Allergy. 2000;30(1):71-8. PubMed PMID: 10606933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway responsiveness to acetaldehyde in patients with asthma: relationship to methacholine responsiveness and peak expiratory flow variation. AU - Prieto,L, AU - Sánchez-Toril,F, AU - Brotons,B, AU - Soriano,S, AU - Casañ,R, AU - Belenguer,J L, PY - 1999/12/22/pubmed PY - 2000/4/1/medline PY - 1999/12/22/entrez SP - 71 EP - 8 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 30 IS - 1 N2 - BACKGROUND: Although airway hyperresponsiveness to inhaled acetaldehyde has been documented in Japanese patients with asthma, the response to this bronchoconstrictor agent has never been studied in Caucasians. OBJECTIVES: The objectives of the study were to determine differences in airway responsiveness to acetaldehyde between asthmatic and healthy subjects, and to examine the relationship between acetaldehyde responsiveness and the variability of peak expiratory flow (PEF). METHODS: The response to methacholine and acetaldehyde challenges was measured in 81 non-smoking adults (61 asthmatics and 20 normal controls). Subjects recorded PEF morning and evening for 14 days. The response to both bronchoconstrictor agents was measured by the PC20 (provocative concentration required to produce a 20% fall in FEV1). PEF variation was expressed as amplitude percentage mean, and as low percentage best (lowest PEF expressed as a percentage of the best PEF recorded). RESULTS: The two types of challenge yielded a similarly high level of sensitivity (100% for methacholine and 92% for acetaldehyde) and specificity (90 and 100%, respectively) to distinguish between asthma and controls. Asthmatic subjects were on average 265-fold less sensitive to acetaldehyde than to methacholine. PC20 acetaldehyde correlated weakly but significantly with both indices of PEF variation (amplitude percentage mean: rho = - 0.36, P = 0. 004; low percentage best: rho = 0.42, P = 0.001). CONCLUSIONS: These results indicate that airway hyperresponsiveness to acetaldehyde is a sensitive and specific indicator for separating asthmatic and normal subjects. Airway responsiveness to methacholine or acetaldehyde and PEF variation are not reflecting the same pathophysiological process in the airways. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/10606933/Airway_responsiveness_to_acetaldehyde_in_patients_with_asthma:_relationship_to_methacholine_responsiveness_and_peak_expiratory_flow_variation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2000&volume=30&issue=1&spage=71 DB - PRIME DP - Unbound Medicine ER -