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Hypopigmented mycosis fungoides: treatment and a 6(1/2)-year follow-up of 9 patients.
J Am Acad Dermatol. 2000 Jan; 42(1 Pt 1):33-9.JA

Abstract

BACKGROUND

The clinical course of hypopigmented mycosis fungoides has not been well described.

OBJECTIVE AND METHODS

We sought to review the management and follow-up of patients with hypopigmented mycosis fungoides evaluated between January 1990 and August 1998.

RESULTS

There were 7 African American and 2 Asian patients (5 male and 4 female patients); 8 had stage Ia and 1 had stage Ib disease. The mean age at diagnosis was 34.4 years, the mean latent period was 9.2 years, and the mean follow-up period after diagnosis was 6.5 years. Treatment modalities used included psoralen UVA, UVB, and topical mechlorethamine. Eight had complete clinical responses, and another had a partial response. The remission period ranged from 2 months to 3 years. In all but one patient, lesions recurred; all responded rapidly to another course of therapy.

CONCLUSION

Hypopigmented mycosis fungoides is characterized by early onset, occurrence in dark-skinned individuals, and good response to therapy. Recurrences are common. In most, it has a biologically benign course.

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Authors+Show Affiliations

Akaraphanth R
Institute of Dermatology, Bangkok, Thailand.
Douglass MC
No affiliation info available
Lim HW
No affiliation info available

MeSH

AdolescentAdultAfrican Continental Ancestry GroupAntineoplastic Agents, AlkylatingAsian Continental Ancestry GroupChildFemaleFollow-Up StudiesHumansHypopigmentationMaleMechlorethamineMiddle AgedMycosis FungoidesPUVA TherapyRecurrenceRemission InductionSkin Neoplasms

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10607317

Citation

Akaraphanth, R, et al. "Hypopigmented Mycosis Fungoides: Treatment and a 6(1/2)-year Follow-up of 9 Patients." Journal of the American Academy of Dermatology, vol. 42, no. 1 Pt 1, 2000, pp. 33-9.
Akaraphanth R, Douglass MC, Lim HW. Hypopigmented mycosis fungoides: treatment and a 6(1/2)-year follow-up of 9 patients. J Am Acad Dermatol. 2000;42(1 Pt 1):33-9.
Akaraphanth, R., Douglass, M. C., & Lim, H. W. (2000). Hypopigmented mycosis fungoides: treatment and a 6(1/2)-year follow-up of 9 patients. Journal of the American Academy of Dermatology, 42(1 Pt 1), 33-9.
Akaraphanth R, Douglass MC, Lim HW. Hypopigmented Mycosis Fungoides: Treatment and a 6(1/2)-year Follow-up of 9 Patients. J Am Acad Dermatol. 2000;42(1 Pt 1):33-9. PubMed PMID: 10607317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypopigmented mycosis fungoides: treatment and a 6(1/2)-year follow-up of 9 patients. AU - Akaraphanth,R, AU - Douglass,M C, AU - Lim,H W, PY - 1999/12/22/pubmed PY - 1999/12/22/medline PY - 1999/12/22/entrez SP - 33 EP - 9 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 42 IS - 1 Pt 1 N2 - BACKGROUND: The clinical course of hypopigmented mycosis fungoides has not been well described. OBJECTIVE AND METHODS: We sought to review the management and follow-up of patients with hypopigmented mycosis fungoides evaluated between January 1990 and August 1998. RESULTS: There were 7 African American and 2 Asian patients (5 male and 4 female patients); 8 had stage Ia and 1 had stage Ib disease. The mean age at diagnosis was 34.4 years, the mean latent period was 9.2 years, and the mean follow-up period after diagnosis was 6.5 years. Treatment modalities used included psoralen UVA, UVB, and topical mechlorethamine. Eight had complete clinical responses, and another had a partial response. The remission period ranged from 2 months to 3 years. In all but one patient, lesions recurred; all responded rapidly to another course of therapy. CONCLUSION: Hypopigmented mycosis fungoides is characterized by early onset, occurrence in dark-skinned individuals, and good response to therapy. Recurrences are common. In most, it has a biologically benign course. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/10607317/Hypopigmented_mycosis_fungoides:_treatment_and_a_6_1/2__year_follow_up_of_9_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(00)90006-9 DB - PRIME DP - Unbound Medicine ER -