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Comparison of terbinafine and griseofulvin in the treatment of tinea capitis.
J Am Acad Dermatol. 2000 Jan; 42(1 Pt 1):80-4.JA

Abstract

BACKGROUND

Griseofulvin has been used for many years in the treatment of tinea capitis. Increase in resistance to this medication has led to a search for new therapeutic alternatives.

OBJECTIVE

Our purpose was to evaluate the therapeutic efficacy of terbinafine in comparison with griseofulvin in the treatment of tinea capitis.

METHODS

We performed a double-blind, randomized, prospective evaluation of 50 patients with a clinical and mycologic diagnosis of tinea capitis. One group received 4 weeks of terbinafine followed by 4 weeks of placebo. The other group received 8 weeks of griseofulvin. We evaluated 5 clinical parameters. Mycologic examinations were performed at baseline and at the end of weeks 8 and 12.

RESULTS

Patients' ages ranged from 1 to 14 years. Fifty-four percent were girls and 46% were boys. Mycologic examinations disclosed Trichophyton tonsurans in 74% of patients and Microsporum canis in 26%. At week 8, the griseofulvin-treated group showed a cure rate of 76%, and the terbinafine-treated group 72%. At week 12, the efficacy of griseofulvin decreased to 44%, whereas the efficacy of terbinafine was 76%.

CONCLUSION

Terbinafine constitutes an alternative for the treatment of tinea capitis. Recurrences were less frequent. No significant side effects were reported.

Authors+Show Affiliations

Department of Pediatric Dermatology, Instituto de Salud del Niño, Peru. spederma@chavin.rcp.net.peNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10607324

Citation

Cáceres-Ríos, H, et al. "Comparison of Terbinafine and Griseofulvin in the Treatment of Tinea Capitis." Journal of the American Academy of Dermatology, vol. 42, no. 1 Pt 1, 2000, pp. 80-4.
Cáceres-Ríos H, Rueda M, Ballona R, et al. Comparison of terbinafine and griseofulvin in the treatment of tinea capitis. J Am Acad Dermatol. 2000;42(1 Pt 1):80-4.
Cáceres-Ríos, H., Rueda, M., Ballona, R., & Bustamante, B. (2000). Comparison of terbinafine and griseofulvin in the treatment of tinea capitis. Journal of the American Academy of Dermatology, 42(1 Pt 1), 80-4.
Cáceres-Ríos H, et al. Comparison of Terbinafine and Griseofulvin in the Treatment of Tinea Capitis. J Am Acad Dermatol. 2000;42(1 Pt 1):80-4. PubMed PMID: 10607324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of terbinafine and griseofulvin in the treatment of tinea capitis. AU - Cáceres-Ríos,H, AU - Rueda,M, AU - Ballona,R, AU - Bustamante,B, PY - 1999/12/22/pubmed PY - 1999/12/22/medline PY - 1999/12/22/entrez SP - 80 EP - 4 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 42 IS - 1 Pt 1 N2 - BACKGROUND: Griseofulvin has been used for many years in the treatment of tinea capitis. Increase in resistance to this medication has led to a search for new therapeutic alternatives. OBJECTIVE: Our purpose was to evaluate the therapeutic efficacy of terbinafine in comparison with griseofulvin in the treatment of tinea capitis. METHODS: We performed a double-blind, randomized, prospective evaluation of 50 patients with a clinical and mycologic diagnosis of tinea capitis. One group received 4 weeks of terbinafine followed by 4 weeks of placebo. The other group received 8 weeks of griseofulvin. We evaluated 5 clinical parameters. Mycologic examinations were performed at baseline and at the end of weeks 8 and 12. RESULTS: Patients' ages ranged from 1 to 14 years. Fifty-four percent were girls and 46% were boys. Mycologic examinations disclosed Trichophyton tonsurans in 74% of patients and Microsporum canis in 26%. At week 8, the griseofulvin-treated group showed a cure rate of 76%, and the terbinafine-treated group 72%. At week 12, the efficacy of griseofulvin decreased to 44%, whereas the efficacy of terbinafine was 76%. CONCLUSION: Terbinafine constitutes an alternative for the treatment of tinea capitis. Recurrences were less frequent. No significant side effects were reported. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/10607324/Comparison_of_terbinafine_and_griseofulvin_in_the_treatment_of_tinea_capitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(00)90013-6 DB - PRIME DP - Unbound Medicine ER -