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CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes.
Int Immunol. 2000 Jan; 12(1):73-82.II

Abstract

Human CD137 is a member of the tumor necrosis factor (TNF) receptor family and the homologue of murine 4-1BB. Recent studies have demonstrated that CD137 promotes accessory T cell activation, and regulates proliferation and survival of T lymphocytes. This study reports on the expression and function of CD137 in peripheral blood monocytes. While monocytes showed constitutive expression in 10 out of 18 healthy donors, CD137 was not expressed on resting T or B lymphocytes. Immobilized antibodies to CD137 markedly induced the production of IL-8 and TNF-alpha protein and mRNA, and led to inhibition of IL-10 expression by primary monocytes. Furthermore, cross-linking of CD137 on monocytes resulted in an increase of B lymphocyte apoptosis mediated by direct cell-cell contact of both cell populations. In conclusion, this study identified CD137 as a new receptor involved in monocyte activation by inducing a characteristic cytokine release profile. In addition, CD137 may play a role in monocyte-dependent control of B lymphocyte survival.

Authors+Show Affiliations

Division of Rheumatology and Clinical Immunology, University Hospital Department of Medicine, Hugstetter Strasse 55, 79106 Freiburg, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10607752

Citation

Kienzle, G, and J von Kempis. "CD137 (ILA/4-1BB), Expressed By Primary Human Monocytes, Induces Monocyte Activation and Apoptosis of B Lymphocytes." International Immunology, vol. 12, no. 1, 2000, pp. 73-82.
Kienzle G, von Kempis J. CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes. Int Immunol. 2000;12(1):73-82.
Kienzle, G., & von Kempis, J. (2000). CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes. International Immunology, 12(1), 73-82.
Kienzle G, von Kempis J. CD137 (ILA/4-1BB), Expressed By Primary Human Monocytes, Induces Monocyte Activation and Apoptosis of B Lymphocytes. Int Immunol. 2000;12(1):73-82. PubMed PMID: 10607752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes. AU - Kienzle,G, AU - von Kempis,J, PY - 1999/12/23/pubmed PY - 2000/2/26/medline PY - 1999/12/23/entrez SP - 73 EP - 82 JF - International immunology JO - Int Immunol VL - 12 IS - 1 N2 - Human CD137 is a member of the tumor necrosis factor (TNF) receptor family and the homologue of murine 4-1BB. Recent studies have demonstrated that CD137 promotes accessory T cell activation, and regulates proliferation and survival of T lymphocytes. This study reports on the expression and function of CD137 in peripheral blood monocytes. While monocytes showed constitutive expression in 10 out of 18 healthy donors, CD137 was not expressed on resting T or B lymphocytes. Immobilized antibodies to CD137 markedly induced the production of IL-8 and TNF-alpha protein and mRNA, and led to inhibition of IL-10 expression by primary monocytes. Furthermore, cross-linking of CD137 on monocytes resulted in an increase of B lymphocyte apoptosis mediated by direct cell-cell contact of both cell populations. In conclusion, this study identified CD137 as a new receptor involved in monocyte activation by inducing a characteristic cytokine release profile. In addition, CD137 may play a role in monocyte-dependent control of B lymphocyte survival. SN - 0953-8178 UR - https://www.unboundmedicine.com/medline/citation/10607752/CD137__ILA/4_1BB__expressed_by_primary_human_monocytes_induces_monocyte_activation_and_apoptosis_of_B_lymphocytes_ L2 - https://academic.oup.com/intimm/article-lookup/doi/10.1093/intimm/12.1.73 DB - PRIME DP - Unbound Medicine ER -