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Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.
J Infect Dis. 2000 Jan; 181(1):2-9.JI

Abstract

Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.

Authors+Show Affiliations

Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. david.vaughn@na.amedd.army.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10608744

Citation

Vaughn, D W., et al. "Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate With Disease Severity." The Journal of Infectious Diseases, vol. 181, no. 1, 2000, pp. 2-9.
Vaughn DW, Green S, Kalayanarooj S, et al. Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. J Infect Dis. 2000;181(1):2-9.
Vaughn, D. W., Green, S., Kalayanarooj, S., Innis, B. L., Nimmannitya, S., Suntayakorn, S., Endy, T. P., Raengsakulrach, B., Rothman, A. L., Ennis, F. A., & Nisalak, A. (2000). Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. The Journal of Infectious Diseases, 181(1), 2-9.
Vaughn DW, et al. Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate With Disease Severity. J Infect Dis. 2000;181(1):2-9. PubMed PMID: 10608744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity. AU - Vaughn,D W, AU - Green,S, AU - Kalayanarooj,S, AU - Innis,B L, AU - Nimmannitya,S, AU - Suntayakorn,S, AU - Endy,T P, AU - Raengsakulrach,B, AU - Rothman,A L, AU - Ennis,F A, AU - Nisalak,A, PY - 1999/12/23/pubmed PY - 2000/3/21/medline PY - 1999/12/23/entrez SP - 2 EP - 9 JF - The Journal of infectious diseases JO - J Infect Dis VL - 181 IS - 1 N2 - Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10608744/Dengue_viremia_titer_antibody_response_pattern_and_virus_serotype_correlate_with_disease_severity_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315215 DB - PRIME DP - Unbound Medicine ER -