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Therapeutic uses of vitamin E in prevention of atherosclerosis.
Altern Med Rev 1999; 4(6):414-23AM

Abstract

The purpose of this review is to present the evidence-based pharmacotherapeutic properties of vitamin E and provide clinical recommendations for use in the arena of atherosclerosis.

METHODS

A literature search was conducted from 1966 through March 1999. All usable papers were retrieved, with large, randomized, double-blinded, clinical trials and epidemiological trials receiving emphasis.

RESULTS

Vitamin E, a lipid soluble vitamin, is a potent antioxidant. Several epidemiological studies have demonstrated positive relationships between vitamin E intake and the prevention of atherosclerotic heart disease; however, only one, large randomized clinical trial (The CHAOS Trial) has been conducted using more than 400 IU per day of vitamin E. Positive outcomes included a 77-percent reduction in nonfatal myocardial infarction (MI), but no corresponding reduction in mortality. Several large clinical trials are ongoing, investigating vitamin E for the prevention of atherosclerosis. Much less work has been undertaken studying vitamin E for prevention of cerebro- and peripheral vascular disease, but there appears to be promise in these areas as well.

CONCLUSIONS

On the basis of the literature search, the authors recommend 400 IU or more per day of vitamin E to patients at high risk or already diagnosed with coronary artery disease. Vitamin E supplementation may also be beneficial in the prevention of cerebro- and peripheral vascular diseases.

Authors+Show Affiliations

Family and Sports Medicine, West Virginia University, Charleston, WV, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10608914

Citation

Swain, R A., and B Kaplan-Machlis. "Therapeutic Uses of Vitamin E in Prevention of Atherosclerosis." Alternative Medicine Review : a Journal of Clinical Therapeutic, vol. 4, no. 6, 1999, pp. 414-23.
Swain RA, Kaplan-Machlis B. Therapeutic uses of vitamin E in prevention of atherosclerosis. Altern Med Rev. 1999;4(6):414-23.
Swain, R. A., & Kaplan-Machlis, B. (1999). Therapeutic uses of vitamin E in prevention of atherosclerosis. Alternative Medicine Review : a Journal of Clinical Therapeutic, 4(6), pp. 414-23.
Swain RA, Kaplan-Machlis B. Therapeutic Uses of Vitamin E in Prevention of Atherosclerosis. Altern Med Rev. 1999;4(6):414-23. PubMed PMID: 10608914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic uses of vitamin E in prevention of atherosclerosis. AU - Swain,R A, AU - Kaplan-Machlis,B, PY - 1999/12/23/pubmed PY - 2000/3/4/medline PY - 1999/12/23/entrez SP - 414 EP - 23 JF - Alternative medicine review : a journal of clinical therapeutic JO - Altern Med Rev VL - 4 IS - 6 N2 - UNLABELLED: The purpose of this review is to present the evidence-based pharmacotherapeutic properties of vitamin E and provide clinical recommendations for use in the arena of atherosclerosis. METHODS: A literature search was conducted from 1966 through March 1999. All usable papers were retrieved, with large, randomized, double-blinded, clinical trials and epidemiological trials receiving emphasis. RESULTS: Vitamin E, a lipid soluble vitamin, is a potent antioxidant. Several epidemiological studies have demonstrated positive relationships between vitamin E intake and the prevention of atherosclerotic heart disease; however, only one, large randomized clinical trial (The CHAOS Trial) has been conducted using more than 400 IU per day of vitamin E. Positive outcomes included a 77-percent reduction in nonfatal myocardial infarction (MI), but no corresponding reduction in mortality. Several large clinical trials are ongoing, investigating vitamin E for the prevention of atherosclerosis. Much less work has been undertaken studying vitamin E for prevention of cerebro- and peripheral vascular disease, but there appears to be promise in these areas as well. CONCLUSIONS: On the basis of the literature search, the authors recommend 400 IU or more per day of vitamin E to patients at high risk or already diagnosed with coronary artery disease. Vitamin E supplementation may also be beneficial in the prevention of cerebro- and peripheral vascular diseases. SN - 1089-5159 UR - https://www.unboundmedicine.com/medline/citation/10608914/Therapeutic_uses_of_vitamin_E_in_prevention_of_atherosclerosis_ L2 - http://archive.foundationalmedicinereview.com/publications/4/6/414.pdf DB - PRIME DP - Unbound Medicine ER -