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Medicinal herbs: drugs or dietary supplements?

Abstract

The process of evaluating medicinal herbs is complex, and there is a need to carefully define a research strategy that addresses a solution to safe and efficacious herbal products. Notwithstanding the immense value of distilling the pharmacological activity of an herb into a chemical suitable for drug development, another approach is to develop a standardized herbal extract that yields consistent pharmacological activity. However, it frequently is forgotten that even in an extract several active ingredients contribute to the pharmacological action. Sufficient evidence exists to suggest that extracts of medicinal herbs, once isolated in their pure state, can produce pharmacological effects that differ significantly from that of the whole herb. This article discusses a research-based strategy that may be suitable for validating, in part, the putative health benefits of medicinal herbs. Additionally, the body of scientific evidence that underpins the pharmacological activity of several herbs is reviewed briefly.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Pharmanex, Inc., Brisbane, CA 94005, USA. jchang@pharmanex.com

    Source

    Biochemical pharmacology 59:3 2000 Feb 01 pg 211-9

    MeSH

    Clinical Trials as Topic
    Dietary Supplements
    Drug Approval
    Forecasting
    Humans
    Phytotherapy
    Plant Extracts
    Plants, Medicinal
    Research Design
    Treatment Outcome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10609549

    Citation

    Chang, J. "Medicinal Herbs: Drugs or Dietary Supplements?" Biochemical Pharmacology, vol. 59, no. 3, 2000, pp. 211-9.
    Chang J. Medicinal herbs: drugs or dietary supplements? Biochem Pharmacol. 2000;59(3):211-9.
    Chang, J. (2000). Medicinal herbs: drugs or dietary supplements? Biochemical Pharmacology, 59(3), pp. 211-9.
    Chang J. Medicinal Herbs: Drugs or Dietary Supplements. Biochem Pharmacol. 2000 Feb 1;59(3):211-9. PubMed PMID: 10609549.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Medicinal herbs: drugs or dietary supplements? A1 - Chang,J, PY - 1999/12/28/pubmed PY - 1999/12/28/medline PY - 1999/12/28/entrez SP - 211 EP - 9 JF - Biochemical pharmacology JO - Biochem. Pharmacol. VL - 59 IS - 3 N2 - The process of evaluating medicinal herbs is complex, and there is a need to carefully define a research strategy that addresses a solution to safe and efficacious herbal products. Notwithstanding the immense value of distilling the pharmacological activity of an herb into a chemical suitable for drug development, another approach is to develop a standardized herbal extract that yields consistent pharmacological activity. However, it frequently is forgotten that even in an extract several active ingredients contribute to the pharmacological action. Sufficient evidence exists to suggest that extracts of medicinal herbs, once isolated in their pure state, can produce pharmacological effects that differ significantly from that of the whole herb. This article discusses a research-based strategy that may be suitable for validating, in part, the putative health benefits of medicinal herbs. Additionally, the body of scientific evidence that underpins the pharmacological activity of several herbs is reviewed briefly. SN - 0006-2952 UR - https://www.unboundmedicine.com/medline/citation/10609549/Medicinal_herbs:_drugs_or_dietary_supplements L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(99)00243-9 DB - PRIME DP - Unbound Medicine ER -