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Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease.

Abstract

Carriers of the apolipoprotein E (APOE) epsilon4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an ongoing longitudinal study of aging and dementia were genotyped. All subjects were at least 60 years old; demented subjects met clinical or pathologic criteria for late-onset AD. Logistic regression analysis and proportional hazard models were used to evaluate joint effects of APOE and gender. A significant statistical interaction between APOE and gender was shown (p = 0.04) in logistic regression analysis. Women carrying one or more APOE-epsilon4 allele were more likely to develop AD [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 3.2-19. 1]. For men, the presence of the APOE-epsilon4 allele was not associated with a statistically significant increased risk (OR = 1.6, 95% CI = 0.5-5.3). The interaction term in the proportional hazards model neared (p = 0.07) statistical significance, and a similar but reduced gender effect was shown. The analysis suggests that the presence of one or more APOE-epsilon4 allele confers a substantially greater risk of AD to women than to men. These findings in part may account for reports of increased risk of AD faced by women.

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  • Authors+Show Affiliations

    ,

    Andrus Gerontology Center, University of Southern California, Los Angeles, USA.

    , , , , , ,

    Source

    MeSH

    Aged
    Aged, 80 and over
    Alleles
    Alzheimer Disease
    Apolipoprotein E4
    Apolipoproteins E
    Female
    Genetic Markers
    Genotype
    Humans
    Logistic Models
    Longitudinal Studies
    Male
    Middle Aged
    Proportional Hazards Models
    Retrospective Studies
    Risk Factors
    Sex Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10609670

    Citation

    Bretsky, P M., et al. "Evidence for an Interaction Between Apolipoprotein E Genotype, Gender, and Alzheimer Disease." Alzheimer Disease and Associated Disorders, vol. 13, no. 4, 1999, pp. 216-21.
    Bretsky PM, Buckwalter JG, Seeman TE, et al. Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. Alzheimer Dis Assoc Disord. 1999;13(4):216-21.
    Bretsky, P. M., Buckwalter, J. G., Seeman, T. E., Miller, C. A., Poirier, J., Schellenberg, G. D., ... Henderson, V. W. (1999). Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. Alzheimer Disease and Associated Disorders, 13(4), pp. 216-21.
    Bretsky PM, et al. Evidence for an Interaction Between Apolipoprotein E Genotype, Gender, and Alzheimer Disease. Alzheimer Dis Assoc Disord. 1999;13(4):216-21. PubMed PMID: 10609670.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. AU - Bretsky,P M, AU - Buckwalter,J G, AU - Seeman,T E, AU - Miller,C A, AU - Poirier,J, AU - Schellenberg,G D, AU - Finch,C E, AU - Henderson,V W, PY - 1999/12/28/pubmed PY - 1999/12/28/medline PY - 1999/12/28/entrez SP - 216 EP - 21 JF - Alzheimer disease and associated disorders JO - Alzheimer Dis Assoc Disord VL - 13 IS - 4 N2 - Carriers of the apolipoprotein E (APOE) epsilon4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an ongoing longitudinal study of aging and dementia were genotyped. All subjects were at least 60 years old; demented subjects met clinical or pathologic criteria for late-onset AD. Logistic regression analysis and proportional hazard models were used to evaluate joint effects of APOE and gender. A significant statistical interaction between APOE and gender was shown (p = 0.04) in logistic regression analysis. Women carrying one or more APOE-epsilon4 allele were more likely to develop AD [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 3.2-19. 1]. For men, the presence of the APOE-epsilon4 allele was not associated with a statistically significant increased risk (OR = 1.6, 95% CI = 0.5-5.3). The interaction term in the proportional hazards model neared (p = 0.07) statistical significance, and a similar but reduced gender effect was shown. The analysis suggests that the presence of one or more APOE-epsilon4 allele confers a substantially greater risk of AD to women than to men. These findings in part may account for reports of increased risk of AD faced by women. SN - 0893-0341 UR - https://www.unboundmedicine.com/medline/citation/10609670/Evidence_for_an_interaction_between_apolipoprotein_E_genotype_gender_and_Alzheimer_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10609670.ui DB - PRIME DP - Unbound Medicine ER -