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Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease.
Alzheimer Dis Assoc Disord 1999 Oct-Dec; 13(4):216-21AD

Abstract

Carriers of the apolipoprotein E (APOE) epsilon4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an ongoing longitudinal study of aging and dementia were genotyped. All subjects were at least 60 years old; demented subjects met clinical or pathologic criteria for late-onset AD. Logistic regression analysis and proportional hazard models were used to evaluate joint effects of APOE and gender. A significant statistical interaction between APOE and gender was shown (p = 0.04) in logistic regression analysis. Women carrying one or more APOE-epsilon4 allele were more likely to develop AD [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 3.2-19. 1]. For men, the presence of the APOE-epsilon4 allele was not associated with a statistically significant increased risk (OR = 1.6, 95% CI = 0.5-5.3). The interaction term in the proportional hazards model neared (p = 0.07) statistical significance, and a similar but reduced gender effect was shown. The analysis suggests that the presence of one or more APOE-epsilon4 allele confers a substantially greater risk of AD to women than to men. These findings in part may account for reports of increased risk of AD faced by women.

Authors+Show Affiliations

Andrus Gerontology Center, University of Southern California, Los Angeles, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10609670

Citation

Bretsky, P M., et al. "Evidence for an Interaction Between Apolipoprotein E Genotype, Gender, and Alzheimer Disease." Alzheimer Disease and Associated Disorders, vol. 13, no. 4, 1999, pp. 216-21.
Bretsky PM, Buckwalter JG, Seeman TE, et al. Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. Alzheimer Dis Assoc Disord. 1999;13(4):216-21.
Bretsky, P. M., Buckwalter, J. G., Seeman, T. E., Miller, C. A., Poirier, J., Schellenberg, G. D., ... Henderson, V. W. (1999). Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. Alzheimer Disease and Associated Disorders, 13(4), pp. 216-21.
Bretsky PM, et al. Evidence for an Interaction Between Apolipoprotein E Genotype, Gender, and Alzheimer Disease. Alzheimer Dis Assoc Disord. 1999;13(4):216-21. PubMed PMID: 10609670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease. AU - Bretsky,P M, AU - Buckwalter,J G, AU - Seeman,T E, AU - Miller,C A, AU - Poirier,J, AU - Schellenberg,G D, AU - Finch,C E, AU - Henderson,V W, PY - 1999/12/28/pubmed PY - 1999/12/28/medline PY - 1999/12/28/entrez SP - 216 EP - 21 JF - Alzheimer disease and associated disorders JO - Alzheimer Dis Assoc Disord VL - 13 IS - 4 N2 - Carriers of the apolipoprotein E (APOE) epsilon4 allele show significantly higher risk of Alzheimer disease (AD). The aim of this present study was to test the hypothesis that a significant interaction exists between APOE genotype and gender on AD. Interactions of epsilon4 by gender, although indicated in the literature, require further verification. A total of 195 past or current control or AD participants in an ongoing longitudinal study of aging and dementia were genotyped. All subjects were at least 60 years old; demented subjects met clinical or pathologic criteria for late-onset AD. Logistic regression analysis and proportional hazard models were used to evaluate joint effects of APOE and gender. A significant statistical interaction between APOE and gender was shown (p = 0.04) in logistic regression analysis. Women carrying one or more APOE-epsilon4 allele were more likely to develop AD [odds ratio (OR) = 7.8, 95% confidence interval (CI) = 3.2-19. 1]. For men, the presence of the APOE-epsilon4 allele was not associated with a statistically significant increased risk (OR = 1.6, 95% CI = 0.5-5.3). The interaction term in the proportional hazards model neared (p = 0.07) statistical significance, and a similar but reduced gender effect was shown. The analysis suggests that the presence of one or more APOE-epsilon4 allele confers a substantially greater risk of AD to women than to men. These findings in part may account for reports of increased risk of AD faced by women. SN - 0893-0341 UR - https://www.unboundmedicine.com/medline/citation/10609670/Evidence_for_an_interaction_between_apolipoprotein_E_genotype_gender_and_Alzheimer_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=10609670.ui DB - PRIME DP - Unbound Medicine ER -