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Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind single-dose study.
Clin Pharmacol Ther. 1999 Dec; 66(6):625-35.CP

Abstract

In a randomized double-blind study, 120 patients with moderate to strong pain after surgical removal of wisdom teeth were given the following in single oral doses: 100-mg enteric-coated diclofenac tablets; 1 g acetaminophen (INN, paracetamol); 1 g acetaminophen plus 60 mg codeine; 100-mg enteric-coated diclofenac tablets plus 1 g acetaminophen; or 100-mg enteric-coated diclofenac tablets plus 1 g acetaminophen plus 60 mg codeine. Patients recorded pain intensity and pain relief for 8 hours. Upside assay sensitivity was confirmed because acetaminophen plus codeine was superior to acetaminophen. Diclofenac plus acetaminophen with and without codeine had superior analgesic effect compared with diclofenac, acetaminophen, or acetaminophen plus codeine. Addition of 60 mg codeine increased the degree of side effects. These results support the clinical practice of combining diclofenac with acetaminophen for acute pain. Of clinical importance are superior and prolonged analgesia and fewer side effects after enteric-coated diclofenac tablets plus acetaminophen compared with acetaminophen plus codeine.

Authors+Show Affiliations

Department of Oral Surgery and Oral Medicine, Institute for Basic Medical Sciences, University of Oslo, Norway.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10613619

Citation

Breivik, E K., et al. "Combining Diclofenac With Acetaminophen or Acetaminophen-codeine After Oral Surgery: a Randomized, Double-blind Single-dose Study." Clinical Pharmacology and Therapeutics, vol. 66, no. 6, 1999, pp. 625-35.
Breivik EK, Barkvoll P, Skovlund E. Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind single-dose study. Clin Pharmacol Ther. 1999;66(6):625-35.
Breivik, E. K., Barkvoll, P., & Skovlund, E. (1999). Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind single-dose study. Clinical Pharmacology and Therapeutics, 66(6), 625-35.
Breivik EK, Barkvoll P, Skovlund E. Combining Diclofenac With Acetaminophen or Acetaminophen-codeine After Oral Surgery: a Randomized, Double-blind Single-dose Study. Clin Pharmacol Ther. 1999;66(6):625-35. PubMed PMID: 10613619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind single-dose study. AU - Breivik,E K, AU - Barkvoll,P, AU - Skovlund,E, PY - 1999/12/29/pubmed PY - 1999/12/29/medline PY - 1999/12/29/entrez SP - 625 EP - 35 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 66 IS - 6 N2 - In a randomized double-blind study, 120 patients with moderate to strong pain after surgical removal of wisdom teeth were given the following in single oral doses: 100-mg enteric-coated diclofenac tablets; 1 g acetaminophen (INN, paracetamol); 1 g acetaminophen plus 60 mg codeine; 100-mg enteric-coated diclofenac tablets plus 1 g acetaminophen; or 100-mg enteric-coated diclofenac tablets plus 1 g acetaminophen plus 60 mg codeine. Patients recorded pain intensity and pain relief for 8 hours. Upside assay sensitivity was confirmed because acetaminophen plus codeine was superior to acetaminophen. Diclofenac plus acetaminophen with and without codeine had superior analgesic effect compared with diclofenac, acetaminophen, or acetaminophen plus codeine. Addition of 60 mg codeine increased the degree of side effects. These results support the clinical practice of combining diclofenac with acetaminophen for acute pain. Of clinical importance are superior and prolonged analgesia and fewer side effects after enteric-coated diclofenac tablets plus acetaminophen compared with acetaminophen plus codeine. SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/10613619/Combining_diclofenac_with_acetaminophen_or_acetaminophen_codeine_after_oral_surgery:_a_randomized_double_blind_single_dose_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0009-9236&date=1999&volume=66&issue=6&spage=625 DB - PRIME DP - Unbound Medicine ER -