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Relation between interleukin-1beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori.
J Gastroenterol. 1999; 34 Suppl 11:10-7.JG

Abstract

The effects of Helicobacter pylori infection on gastric acid secretion has not been clarified. The aim of this study was to elucidate the effects of H. pylori infection on gastric juice pH in relation to gene expression of interleukin-1beta (IL-1beta), which is reported to inhibit gastric acid secretion. Gastric juice pH and serum gastrin levels were measured in patients with peptic ulcer disease. The amount of IL-1beta mRNA in gastric fundic gland mucosa was also measured by a competitive reverse transcription-polymerase chain reaction method. These parameters were determined before and after treatment with lansoprazole and amoxicillin. Before treatment a significant positive relation was observed between the amount of IL-1beta mRNA in gastric fundic gland mucosa and gastric juice pH. After treatment significant decreases in the amount of IL-1beta mRNA, gastric juice pH, and serum gastrin levels were observed in patients with eradication of H. pylori, whereas no significant changes were observed in patients without eradication. These results suggest that H. pylori infection induces IL-1beta and suppresses acid secretion, resulting in increases in gastric juice pH and serum gastrin levels. Eradication of H. pylori decreases IL-1beta induction, resulting in an increase in gastric juice acidity and normalization of serum gastrin levels.

Authors+Show Affiliations

First Department of Medicine, Hamamatsu University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10616759

Citation

Wang, M, et al. "Relation Between Interleukin-1beta Messenger RNA in Gastric Fundic Mucosa and Gastric Juice pH in Patients Infected With Helicobacter Pylori." Journal of Gastroenterology, vol. 34 Suppl 11, 1999, pp. 10-7.
Wang M, Furuta T, Takashima M, et al. Relation between interleukin-1beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori. J Gastroenterol. 1999;34 Suppl 11:10-7.
Wang, M., Furuta, T., Takashima, M., Futami, H., Shirai, N., Hanai, H., & Kaneko, E. (1999). Relation between interleukin-1beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori. Journal of Gastroenterology, 34 Suppl 11, 10-7.
Wang M, et al. Relation Between Interleukin-1beta Messenger RNA in Gastric Fundic Mucosa and Gastric Juice pH in Patients Infected With Helicobacter Pylori. J Gastroenterol. 1999;34 Suppl 11:10-7. PubMed PMID: 10616759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between interleukin-1beta messenger RNA in gastric fundic mucosa and gastric juice pH in patients infected with Helicobacter pylori. AU - Wang,M, AU - Furuta,T, AU - Takashima,M, AU - Futami,H, AU - Shirai,N, AU - Hanai,H, AU - Kaneko,E, PY - 2000/1/5/pubmed PY - 2000/1/5/medline PY - 2000/1/5/entrez SP - 10 EP - 7 JF - Journal of gastroenterology JO - J Gastroenterol VL - 34 Suppl 11 N2 - The effects of Helicobacter pylori infection on gastric acid secretion has not been clarified. The aim of this study was to elucidate the effects of H. pylori infection on gastric juice pH in relation to gene expression of interleukin-1beta (IL-1beta), which is reported to inhibit gastric acid secretion. Gastric juice pH and serum gastrin levels were measured in patients with peptic ulcer disease. The amount of IL-1beta mRNA in gastric fundic gland mucosa was also measured by a competitive reverse transcription-polymerase chain reaction method. These parameters were determined before and after treatment with lansoprazole and amoxicillin. Before treatment a significant positive relation was observed between the amount of IL-1beta mRNA in gastric fundic gland mucosa and gastric juice pH. After treatment significant decreases in the amount of IL-1beta mRNA, gastric juice pH, and serum gastrin levels were observed in patients with eradication of H. pylori, whereas no significant changes were observed in patients without eradication. These results suggest that H. pylori infection induces IL-1beta and suppresses acid secretion, resulting in increases in gastric juice pH and serum gastrin levels. Eradication of H. pylori decreases IL-1beta induction, resulting in an increase in gastric juice acidity and normalization of serum gastrin levels. SN - 0944-1174 UR - https://www.unboundmedicine.com/medline/citation/10616759/Relation_between_interleukin_1beta_messenger_RNA_in_gastric_fundic_mucosa_and_gastric_juice_pH_in_patients_infected_with_Helicobacter_pylori_ L2 - https://medlineplus.gov/pepticulcer.html DB - PRIME DP - Unbound Medicine ER -