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Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra.
J Ethnopharmacol 1999; 67(1):111-9JE

Abstract

The active-oxygen scavenging activity of 70 traditional herbal medicines used in China and Japan as nourishing tonics were evaluated by electron spin resonance (ESR) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. Most of the 70 herbal medicines showed scavenging activity with various intensities. Areca catechu (methanol extract), Dendrobium plicatile (methanol extract), Juglans regia (water extract), Paeonia lactiflora (methanol extract), Psychotria serpens (water and methanol extracts), Rhodiola sacra (water and methanol extracts) and Uncaria rhynchophylla (water extract) especially showed strong scavenging activity against superoxide anion radical (*O2-), while J. regia (water and methanol extracts), Morus alba (water extract) and Schisandra chinensis (water extract) revealed strong scavenging activity against hydroxyl radical (HO*). In addition, the active-oxygen scavenging activities of 19 compounds isolated from R. sacra were also examined, and hydroquinone (1), caffeic acid (3), protocatechuic acid (6), gallic acid (7), (-)-epigallocatechin 3-O-gallate (8), 3-O-galloylepigallocatechin-(4beta-->8)-epigallocatechin+ ++ 3-O-gallate (10), heterodendrin (17) and gallic acid 4-O-beta-D-glucopyranoside (19) were found to show mild or strong inhibitory activity against superoxide anion radical (*O2-), while 4-hydroxybenzoic acid (2), 3, 4-hydroxycinnamic acid (4), 6-8 and 19 inhibited hydroxyl radical (OH*). These active-oxygen scavengers may contribute, to different extents, to their anti-aging action.

Authors+Show Affiliations

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10616967

Citation

Ohsugi, M, et al. "Active-oxygen Scavenging Activity of Traditional Nourishing-tonic Herbal Medicines and Active Constituents of Rhodiola Sacra." Journal of Ethnopharmacology, vol. 67, no. 1, 1999, pp. 111-9.
Ohsugi M, Fan W, Hase K, et al. Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol. 1999;67(1):111-9.
Ohsugi, M., Fan, W., Hase, K., Xiong, Q., Tezuka, Y., Komatsu, K., ... Kadota, S. (1999). Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. Journal of Ethnopharmacology, 67(1), pp. 111-9.
Ohsugi M, et al. Active-oxygen Scavenging Activity of Traditional Nourishing-tonic Herbal Medicines and Active Constituents of Rhodiola Sacra. J Ethnopharmacol. 1999;67(1):111-9. PubMed PMID: 10616967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. AU - Ohsugi,M, AU - Fan,W, AU - Hase,K, AU - Xiong,Q, AU - Tezuka,Y, AU - Komatsu,K, AU - Namba,T, AU - Saitoh,T, AU - Tazawa,K, AU - Kadota,S, PY - 2000/1/5/pubmed PY - 2000/1/5/medline PY - 2000/1/5/entrez SP - 111 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 67 IS - 1 N2 - The active-oxygen scavenging activity of 70 traditional herbal medicines used in China and Japan as nourishing tonics were evaluated by electron spin resonance (ESR) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. Most of the 70 herbal medicines showed scavenging activity with various intensities. Areca catechu (methanol extract), Dendrobium plicatile (methanol extract), Juglans regia (water extract), Paeonia lactiflora (methanol extract), Psychotria serpens (water and methanol extracts), Rhodiola sacra (water and methanol extracts) and Uncaria rhynchophylla (water extract) especially showed strong scavenging activity against superoxide anion radical (*O2-), while J. regia (water and methanol extracts), Morus alba (water extract) and Schisandra chinensis (water extract) revealed strong scavenging activity against hydroxyl radical (HO*). In addition, the active-oxygen scavenging activities of 19 compounds isolated from R. sacra were also examined, and hydroquinone (1), caffeic acid (3), protocatechuic acid (6), gallic acid (7), (-)-epigallocatechin 3-O-gallate (8), 3-O-galloylepigallocatechin-(4beta-->8)-epigallocatechin+ ++ 3-O-gallate (10), heterodendrin (17) and gallic acid 4-O-beta-D-glucopyranoside (19) were found to show mild or strong inhibitory activity against superoxide anion radical (*O2-), while 4-hydroxybenzoic acid (2), 3, 4-hydroxycinnamic acid (4), 6-8 and 19 inhibited hydroxyl radical (OH*). These active-oxygen scavengers may contribute, to different extents, to their anti-aging action. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/10616967/Active_oxygen_scavenging_activity_of_traditional_nourishing_tonic_herbal_medicines_and_active_constituents_of_Rhodiola_sacra_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378874198002451 DB - PRIME DP - Unbound Medicine ER -