Tags

Type your tag names separated by a space and hit enter

Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra.

Abstract

The active-oxygen scavenging activity of 70 traditional herbal medicines used in China and Japan as nourishing tonics were evaluated by electron spin resonance (ESR) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. Most of the 70 herbal medicines showed scavenging activity with various intensities. Areca catechu (methanol extract), Dendrobium plicatile (methanol extract), Juglans regia (water extract), Paeonia lactiflora (methanol extract), Psychotria serpens (water and methanol extracts), Rhodiola sacra (water and methanol extracts) and Uncaria rhynchophylla (water extract) especially showed strong scavenging activity against superoxide anion radical (*O2-), while J. regia (water and methanol extracts), Morus alba (water extract) and Schisandra chinensis (water extract) revealed strong scavenging activity against hydroxyl radical (HO*). In addition, the active-oxygen scavenging activities of 19 compounds isolated from R. sacra were also examined, and hydroquinone (1), caffeic acid (3), protocatechuic acid (6), gallic acid (7), (-)-epigallocatechin 3-O-gallate (8), 3-O-galloylepigallocatechin-(4beta-->8)-epigallocatechin+ ++ 3-O-gallate (10), heterodendrin (17) and gallic acid 4-O-beta-D-glucopyranoside (19) were found to show mild or strong inhibitory activity against superoxide anion radical (*O2-), while 4-hydroxybenzoic acid (2), 3, 4-hydroxycinnamic acid (4), 6-8 and 19 inhibited hydroxyl radical (OH*). These active-oxygen scavengers may contribute, to different extents, to their anti-aging action.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan.

    , , , , , , , ,

    Source

    Journal of ethnopharmacology 67:1 1999 Oct pg 111-9

    MeSH

    Antioxidants
    China
    Electron Spin Resonance Spectroscopy
    Free Radical Scavengers
    Humans
    Japan
    Medicine, East Asian Traditional
    Plant Extracts
    Plants, Medicinal

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10616967

    Citation

    Ohsugi, M, et al. "Active-oxygen Scavenging Activity of Traditional Nourishing-tonic Herbal Medicines and Active Constituents of Rhodiola Sacra." Journal of Ethnopharmacology, vol. 67, no. 1, 1999, pp. 111-9.
    Ohsugi M, Fan W, Hase K, et al. Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol. 1999;67(1):111-9.
    Ohsugi, M., Fan, W., Hase, K., Xiong, Q., Tezuka, Y., Komatsu, K., ... Kadota, S. (1999). Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. Journal of Ethnopharmacology, 67(1), pp. 111-9.
    Ohsugi M, et al. Active-oxygen Scavenging Activity of Traditional Nourishing-tonic Herbal Medicines and Active Constituents of Rhodiola Sacra. J Ethnopharmacol. 1999;67(1):111-9. PubMed PMID: 10616967.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. AU - Ohsugi,M, AU - Fan,W, AU - Hase,K, AU - Xiong,Q, AU - Tezuka,Y, AU - Komatsu,K, AU - Namba,T, AU - Saitoh,T, AU - Tazawa,K, AU - Kadota,S, PY - 2000/1/5/pubmed PY - 2000/1/5/medline PY - 2000/1/5/entrez SP - 111 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 67 IS - 1 N2 - The active-oxygen scavenging activity of 70 traditional herbal medicines used in China and Japan as nourishing tonics were evaluated by electron spin resonance (ESR) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. Most of the 70 herbal medicines showed scavenging activity with various intensities. Areca catechu (methanol extract), Dendrobium plicatile (methanol extract), Juglans regia (water extract), Paeonia lactiflora (methanol extract), Psychotria serpens (water and methanol extracts), Rhodiola sacra (water and methanol extracts) and Uncaria rhynchophylla (water extract) especially showed strong scavenging activity against superoxide anion radical (*O2-), while J. regia (water and methanol extracts), Morus alba (water extract) and Schisandra chinensis (water extract) revealed strong scavenging activity against hydroxyl radical (HO*). In addition, the active-oxygen scavenging activities of 19 compounds isolated from R. sacra were also examined, and hydroquinone (1), caffeic acid (3), protocatechuic acid (6), gallic acid (7), (-)-epigallocatechin 3-O-gallate (8), 3-O-galloylepigallocatechin-(4beta-->8)-epigallocatechin+ ++ 3-O-gallate (10), heterodendrin (17) and gallic acid 4-O-beta-D-glucopyranoside (19) were found to show mild or strong inhibitory activity against superoxide anion radical (*O2-), while 4-hydroxybenzoic acid (2), 3, 4-hydroxycinnamic acid (4), 6-8 and 19 inhibited hydroxyl radical (OH*). These active-oxygen scavengers may contribute, to different extents, to their anti-aging action. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/10616967/Active_oxygen_scavenging_activity_of_traditional_nourishing_tonic_herbal_medicines_and_active_constituents_of_Rhodiola_sacra_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378874198002451 DB - PRIME DP - Unbound Medicine ER -