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Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder.
Am J Clin Nutr. 2000 01; 71(1 Suppl):327S-30S.AJ

Abstract

Attention-deficit hyperactivity disorder (ADHD) is the diagnosis used to describe children who are inattentive, impulsive, and hyperactive. ADHD is a widespread condition that is of public health concern. In most children with ADHD the cause is unknown, but is thought to be biological and multifactorial. Several previous studies indicated that some physical symptoms reported in ADHD are similar to symptoms observed in essential fatty acid (EFA) deficiency in animals and humans deprived of EFAs. We reported previously that a subgroup of ADHD subjects reporting many symptoms indicative of EFA deficiency (L-ADHD) had significantly lower proportions of plasma arachidonic acid and docosahexaenoic acid than did ADHD subjects with few such symptoms or control subjects. In another study using contrast analysis of the plasma polar lipid data, subjects with lower compositions of total n-3 fatty acids had significantly more behavioral problems, temper tantrums, and learning, health, and sleep problems than did those with high proportions of n-3 fatty acids. The reasons for the lower proportions of long-chain polyunsaturated fatty acids (LCPUFAs) in these children are not clear; however, factors involving fatty acid intake, conversion of EFAs to LCPUFA products, and enhanced metabolism are discussed. The relation between LCPUFA status and the behavior problems that the children exhibited is also unclear. We are currently testing this relation in a double-blind, placebo-controlled intervention in a population of children with clinically diagnosed ADHD who exhibit symptoms of EFA deficiency.

Authors+Show Affiliations

Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-1264, USA. burgessj@cfs.purdue.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10617991

Citation

Burgess, J R., et al. "Long-chain Polyunsaturated Fatty Acids in Children With Attention-deficit Hyperactivity Disorder." The American Journal of Clinical Nutrition, vol. 71, no. 1 Suppl, 2000, 327S-30S.
Burgess JR, Stevens L, Zhang W, et al. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. Am J Clin Nutr. 2000;71(1 Suppl):327S-30S.
Burgess, J. R., Stevens, L., Zhang, W., & Peck, L. (2000). Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. The American Journal of Clinical Nutrition, 71(1 Suppl), 327S-30S. https://doi.org/10.1093/ajcn/71.1.327S
Burgess JR, et al. Long-chain Polyunsaturated Fatty Acids in Children With Attention-deficit Hyperactivity Disorder. Am J Clin Nutr. 2000;71(1 Suppl):327S-30S. PubMed PMID: 10617991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. AU - Burgess,J R, AU - Stevens,L, AU - Zhang,W, AU - Peck,L, PY - 2000/1/5/pubmed PY - 2000/1/5/medline PY - 2000/1/5/entrez SP - 327S EP - 30S JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 71 IS - 1 Suppl N2 - Attention-deficit hyperactivity disorder (ADHD) is the diagnosis used to describe children who are inattentive, impulsive, and hyperactive. ADHD is a widespread condition that is of public health concern. In most children with ADHD the cause is unknown, but is thought to be biological and multifactorial. Several previous studies indicated that some physical symptoms reported in ADHD are similar to symptoms observed in essential fatty acid (EFA) deficiency in animals and humans deprived of EFAs. We reported previously that a subgroup of ADHD subjects reporting many symptoms indicative of EFA deficiency (L-ADHD) had significantly lower proportions of plasma arachidonic acid and docosahexaenoic acid than did ADHD subjects with few such symptoms or control subjects. In another study using contrast analysis of the plasma polar lipid data, subjects with lower compositions of total n-3 fatty acids had significantly more behavioral problems, temper tantrums, and learning, health, and sleep problems than did those with high proportions of n-3 fatty acids. The reasons for the lower proportions of long-chain polyunsaturated fatty acids (LCPUFAs) in these children are not clear; however, factors involving fatty acid intake, conversion of EFAs to LCPUFA products, and enhanced metabolism are discussed. The relation between LCPUFA status and the behavior problems that the children exhibited is also unclear. We are currently testing this relation in a double-blind, placebo-controlled intervention in a population of children with clinically diagnosed ADHD who exhibit symptoms of EFA deficiency. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/10617991/Long_chain_polyunsaturated_fatty_acids_in_children_with_attention_deficit_hyperactivity_disorder_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/71.1.327S DB - PRIME DP - Unbound Medicine ER -