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The persistent efficacy of doramectin pour-on against biting and sucking louse infestations of cattle.
Vet Parasitol. 2000 Jan; 87(2-3):183-92.VP

Abstract

A repeated-exposure challenge model was used to evaluate the pour-on formulation of doramectin in preventing the establishment of louse infestations in cattle. Twenty calves cleared of preexisting biting and sucking louse infestations were randomly and equally allocated to either a doramectin-treated or untreated control group, with five replicates per group. Doramectin pour-on was administered topically at a dose rate of 500 microg/kg body weight. Every 14 days, from a pool of seeder calves with infestations of at least 50 biting and 50 sucking lice each, 10 calves were selected and 1 was placed in each replicate pen. Every week during the 112-day study, 9 predilection sites on the doramectin-treated and untreated calves were examined to estimate the louse population density. A calf met the infestation criterion for a louse species when two or more live lice were counted on two or more body regions for two consecutive count days. Because only 4 of 10 untreated calves acquired Solenopotes capillatus infestations, the persistent efficacy of doramectin against S. capillatus was not evaluated. Bovicola bovis and Linognathus vituli infestations in the untreated calves developed shortly after exposure to infested seeder calves. The acquisition of B. bovis and L. vituli infestations in the doramectin-treated group was delayed for 77 days and 105 days, respectively.

Authors+Show Affiliations

Pfizer Animal Health Group, Lee's Summit, MO 64081-2998, USA. skoget@pfizer.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10622610

Citation

Skogerboe, T L., et al. "The Persistent Efficacy of Doramectin Pour-on Against Biting and Sucking Louse Infestations of Cattle." Veterinary Parasitology, vol. 87, no. 2-3, 2000, pp. 183-92.
Skogerboe TL, Smith LL, Karle VK, et al. The persistent efficacy of doramectin pour-on against biting and sucking louse infestations of cattle. Vet Parasitol. 2000;87(2-3):183-92.
Skogerboe, T. L., Smith, L. L., Karle, V. K., & Derozier, C. L. (2000). The persistent efficacy of doramectin pour-on against biting and sucking louse infestations of cattle. Veterinary Parasitology, 87(2-3), 183-92.
Skogerboe TL, et al. The Persistent Efficacy of Doramectin Pour-on Against Biting and Sucking Louse Infestations of Cattle. Vet Parasitol. 2000;87(2-3):183-92. PubMed PMID: 10622610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The persistent efficacy of doramectin pour-on against biting and sucking louse infestations of cattle. AU - Skogerboe,T L, AU - Smith,L L, AU - Karle,V K, AU - Derozier,C L, PY - 2000/1/6/pubmed PY - 2000/3/11/medline PY - 2000/1/6/entrez SP - 183 EP - 92 JF - Veterinary parasitology JO - Vet. Parasitol. VL - 87 IS - 2-3 N2 - A repeated-exposure challenge model was used to evaluate the pour-on formulation of doramectin in preventing the establishment of louse infestations in cattle. Twenty calves cleared of preexisting biting and sucking louse infestations were randomly and equally allocated to either a doramectin-treated or untreated control group, with five replicates per group. Doramectin pour-on was administered topically at a dose rate of 500 microg/kg body weight. Every 14 days, from a pool of seeder calves with infestations of at least 50 biting and 50 sucking lice each, 10 calves were selected and 1 was placed in each replicate pen. Every week during the 112-day study, 9 predilection sites on the doramectin-treated and untreated calves were examined to estimate the louse population density. A calf met the infestation criterion for a louse species when two or more live lice were counted on two or more body regions for two consecutive count days. Because only 4 of 10 untreated calves acquired Solenopotes capillatus infestations, the persistent efficacy of doramectin against S. capillatus was not evaluated. Bovicola bovis and Linognathus vituli infestations in the untreated calves developed shortly after exposure to infested seeder calves. The acquisition of B. bovis and L. vituli infestations in the doramectin-treated group was delayed for 77 days and 105 days, respectively. SN - 0304-4017 UR - https://www.unboundmedicine.com/medline/citation/10622610/The_persistent_efficacy_of_doramectin_pour_on_against_biting_and_sucking_louse_infestations_of_cattle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(99)00186-7 DB - PRIME DP - Unbound Medicine ER -