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Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters.
Nutr Cancer. 1999; 35(1):73-9.NC

Abstract

The preventive effects of green tea, tea pigments, and mixed tea (a composite of whole water extract of green tea, tea polyphenols, and tea pigments) on 7,12-dimethyl-benz[a]anthracene (DMBA)-induced oral carcinogenesis in golden Syrian hamsters were studied. The right buccal pouches of animals were topically treated with 0.5% DMBA three times per week for 15 weeks. Animals were killed separately after 6, 10, and 15 weeks of DMBA treatment. Oral tumors were counted and measured, and mean tumor burden was calculated. The incidence of preneoplastic lesions and micronucleated cells, the number and volume of silver-stained nucleolar organizer regions (AgNOR), the labeling index of proliferating cell nuclear antigen, and the level of epidermal growth factor receptor expression were studied. The results showed that oral administration of 1.5% green tea, 0.1% tea pigments, and 0.5% mixed tea as the sole source of drinking water for two weeks before initiation of the DMBA treatment and until the end of the experiment significantly reduced the mean tumor burden and the incidence of dysplasia and oral carcinoma (p < 0.01). The frequency of micronucleated cells, the number of AgNOR, the total volume of AgNORs, the labeling index of proliferating cell nuclear antigen, and the level of epidermal growth factor receptor expression in the oral mucosal cells were also significantly reduced (p < 0.01). These results clearly indicated that tea preparations could effectively inhibit DMBA-induced oral carcinogenesis in hamsters. Protection from DNA damage and suppression of cell proliferation could be important mechanisms of the anticarcinogenic effects of the tea preparations.

Authors+Show Affiliations

Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10624709

Citation

Li, N, et al. "Tea Preparations Protect Against DMBA-induced Oral Carcinogenesis in Hamsters." Nutrition and Cancer, vol. 35, no. 1, 1999, pp. 73-9.
Li N, Han C, Chen J. Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters. Nutr Cancer. 1999;35(1):73-9.
Li, N., Han, C., & Chen, J. (1999). Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters. Nutrition and Cancer, 35(1), 73-9.
Li N, Han C, Chen J. Tea Preparations Protect Against DMBA-induced Oral Carcinogenesis in Hamsters. Nutr Cancer. 1999;35(1):73-9. PubMed PMID: 10624709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tea preparations protect against DMBA-induced oral carcinogenesis in hamsters. AU - Li,N, AU - Han,C, AU - Chen,J, PY - 2000/1/7/pubmed PY - 2000/1/7/medline PY - 2000/1/7/entrez SP - 73 EP - 9 JF - Nutrition and cancer JO - Nutr Cancer VL - 35 IS - 1 N2 - The preventive effects of green tea, tea pigments, and mixed tea (a composite of whole water extract of green tea, tea polyphenols, and tea pigments) on 7,12-dimethyl-benz[a]anthracene (DMBA)-induced oral carcinogenesis in golden Syrian hamsters were studied. The right buccal pouches of animals were topically treated with 0.5% DMBA three times per week for 15 weeks. Animals were killed separately after 6, 10, and 15 weeks of DMBA treatment. Oral tumors were counted and measured, and mean tumor burden was calculated. The incidence of preneoplastic lesions and micronucleated cells, the number and volume of silver-stained nucleolar organizer regions (AgNOR), the labeling index of proliferating cell nuclear antigen, and the level of epidermal growth factor receptor expression were studied. The results showed that oral administration of 1.5% green tea, 0.1% tea pigments, and 0.5% mixed tea as the sole source of drinking water for two weeks before initiation of the DMBA treatment and until the end of the experiment significantly reduced the mean tumor burden and the incidence of dysplasia and oral carcinoma (p < 0.01). The frequency of micronucleated cells, the number of AgNOR, the total volume of AgNORs, the labeling index of proliferating cell nuclear antigen, and the level of epidermal growth factor receptor expression in the oral mucosal cells were also significantly reduced (p < 0.01). These results clearly indicated that tea preparations could effectively inhibit DMBA-induced oral carcinogenesis in hamsters. Protection from DNA damage and suppression of cell proliferation could be important mechanisms of the anticarcinogenic effects of the tea preparations. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/10624709/Tea_preparations_protect_against_DMBA_induced_oral_carcinogenesis_in_hamsters_ L2 - https://www.tandfonline.com/doi/full/10.1207/S1532791473-79 DB - PRIME DP - Unbound Medicine ER -