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The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients.
Aliment Pharmacol Ther 2000; 14(1):35-43AP

Abstract

OBJECTIVES

To evaluate the impact of a 1-year gluten-free diet on bone metabolism and nutritional status in coeliac disease.

METHODS

Bone mineral density, serum indices of bone remodelling, clinical and biochemical nutritional assessment were evaluated in 86 consecutive newly-diagnosed, biopsy proven, coeliac disease patients (untreated). A complete reevaluation, including intestinal biopsy, was repeated within 1 year of dietary treatment (treated).

RESULTS

Untreated: according to WHO criteria, 34% of patients had a normal bone mineral density, 40% had osteopenia and 26% osteoporosis. Between males and females there were no statistical differences in bone metabolism or in most of the nutritional indices, while, between fertile and postmenopausal women, bone mineral density and several bone metabolism markers were significantly different. Compared to subjects with a normal bone mineral density, osteopenics had higher bone specific alkaline phosphatase (BAP) and Bone-Gla-protein (BGP) values. In patients with a concomitant BAP increase and 25OH vitamin D serum level reduction, bone mineral density and several bone turnover markers were statistically different compared to patients without such a serological pattern. Treated: notwithstanding intestinal biopsy which showed a mucosal recovery in only 57%, gluten-free diet led, even in postmenopausal women, to a significant improvement in bone mineral density, bone metabolism and nutrition, except for folic acid, albumin and pre-albumin serum levels which persisted as abnormal in patients with obdurate mucosal impairment.

CONCLUSIONS

Coeliac disease patients are at high risk for developing a low bone mineral density and bone turnover impairment. A gluten-free diet can improve this situation even in postmenopausal women and in patients with incomplete mucosal recovery.

Authors+Show Affiliations

Dipartimento di Medicina Interna, Universitá di Torino, Italy. carla.sategna@unito.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10632643

Citation

Sategna-Guidetti, C, et al. "The Effects of 1-year Gluten Withdrawal On Bone Mass, Bone Metabolism and Nutritional Status in Newly-diagnosed Adult Coeliac Disease Patients." Alimentary Pharmacology & Therapeutics, vol. 14, no. 1, 2000, pp. 35-43.
Sategna-Guidetti C, Grosso SB, Grosso S, et al. The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients. Aliment Pharmacol Ther. 2000;14(1):35-43.
Sategna-Guidetti, C., Grosso, S. B., Grosso, S., Mengozzi, G., Aimo, G., Zaccaria, T., ... Isaia, G. C. (2000). The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients. Alimentary Pharmacology & Therapeutics, 14(1), pp. 35-43.
Sategna-Guidetti C, et al. The Effects of 1-year Gluten Withdrawal On Bone Mass, Bone Metabolism and Nutritional Status in Newly-diagnosed Adult Coeliac Disease Patients. Aliment Pharmacol Ther. 2000;14(1):35-43. PubMed PMID: 10632643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of 1-year gluten withdrawal on bone mass, bone metabolism and nutritional status in newly-diagnosed adult coeliac disease patients. AU - Sategna-Guidetti,C, AU - Grosso,S B, AU - Grosso,S, AU - Mengozzi,G, AU - Aimo,G, AU - Zaccaria,T, AU - Di Stefano,M, AU - Isaia,G C, PY - 2000/1/13/pubmed PY - 2000/2/19/medline PY - 2000/1/13/entrez SP - 35 EP - 43 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 14 IS - 1 N2 - OBJECTIVES: To evaluate the impact of a 1-year gluten-free diet on bone metabolism and nutritional status in coeliac disease. METHODS: Bone mineral density, serum indices of bone remodelling, clinical and biochemical nutritional assessment were evaluated in 86 consecutive newly-diagnosed, biopsy proven, coeliac disease patients (untreated). A complete reevaluation, including intestinal biopsy, was repeated within 1 year of dietary treatment (treated). RESULTS: Untreated: according to WHO criteria, 34% of patients had a normal bone mineral density, 40% had osteopenia and 26% osteoporosis. Between males and females there were no statistical differences in bone metabolism or in most of the nutritional indices, while, between fertile and postmenopausal women, bone mineral density and several bone metabolism markers were significantly different. Compared to subjects with a normal bone mineral density, osteopenics had higher bone specific alkaline phosphatase (BAP) and Bone-Gla-protein (BGP) values. In patients with a concomitant BAP increase and 25OH vitamin D serum level reduction, bone mineral density and several bone turnover markers were statistically different compared to patients without such a serological pattern. Treated: notwithstanding intestinal biopsy which showed a mucosal recovery in only 57%, gluten-free diet led, even in postmenopausal women, to a significant improvement in bone mineral density, bone metabolism and nutrition, except for folic acid, albumin and pre-albumin serum levels which persisted as abnormal in patients with obdurate mucosal impairment. CONCLUSIONS: Coeliac disease patients are at high risk for developing a low bone mineral density and bone turnover impairment. A gluten-free diet can improve this situation even in postmenopausal women and in patients with incomplete mucosal recovery. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/10632643/The_effects_of_1_year_gluten_withdrawal_on_bone_mass_bone_metabolism_and_nutritional_status_in_newly_diagnosed_adult_coeliac_disease_patients_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0269-2813&date=2000&volume=14&issue=1&spage=35 DB - PRIME DP - Unbound Medicine ER -