Tags

Type your tag names separated by a space and hit enter

The effects of capsaicin on reflux, gastric emptying and dyspepsia.
Aliment Pharmacol Ther 2000; 14(1):129-34AP

Abstract

AIMS

To evaluate capsaicin's effects on heartburn, dyspepsia, gastric acidity and emptying, and gastro-oesophageal reflux, and to test the hypothesis that capsaicin induces heartburn and exacerbates symptoms by sensitizing the oesophagus.

METHODS

Eleven heartburn sufferers underwent two separate pH monitoring sessions and assessments of gastric emptying (13C-octanoic acid breath test), heartburn and dyspepsia (100 mm VAS) after a non-irritant meal. The meal consisted of a sausage biscuit with egg, cheese and 30 g raw onion, 8 oz chocolate milk and a peppermint patty. Thirty minutes prior to meal consumption, subjects were administered a placebo capsule. On visit 1, subjects consumed the meal containing 100 microl 13C-octanoic acid cooked in the egg, over 15 min. On visit 2, subjects consumed the meal plus 5 mg capsaicin in gelatin capsules.

RESULTS

Oesophageal and gastric pH profiles and gastric emptying were not different between meals. Capsaicin did not alter mean heartburn and dyspepsia scores (P > 0.05), but significantly decreased time to peak heartburn (120 min vs. 247 min; P < 0.003). Time to peak dyspepsia was not altered by capsaicin (P > 0.05).

CONCLUSION

Capsaicin enhances noxious postprandial heartburn, presumably by direct effects on sensory neurons.

Authors+Show Affiliations

The Oklahoma Foundation for Digestive Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. sheila-stanley@ouhsc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

10632656

Citation

Rodriguez-Stanley, S, et al. "The Effects of Capsaicin On Reflux, Gastric Emptying and Dyspepsia." Alimentary Pharmacology & Therapeutics, vol. 14, no. 1, 2000, pp. 129-34.
Rodriguez-Stanley S, Collings KL, Robinson M, et al. The effects of capsaicin on reflux, gastric emptying and dyspepsia. Aliment Pharmacol Ther. 2000;14(1):129-34.
Rodriguez-Stanley, S., Collings, K. L., Robinson, M., Owen, W., & Miner, P. B. (2000). The effects of capsaicin on reflux, gastric emptying and dyspepsia. Alimentary Pharmacology & Therapeutics, 14(1), pp. 129-34.
Rodriguez-Stanley S, et al. The Effects of Capsaicin On Reflux, Gastric Emptying and Dyspepsia. Aliment Pharmacol Ther. 2000;14(1):129-34. PubMed PMID: 10632656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of capsaicin on reflux, gastric emptying and dyspepsia. AU - Rodriguez-Stanley,S, AU - Collings,K L, AU - Robinson,M, AU - Owen,W, AU - Miner,P B,Jr PY - 2000/1/13/pubmed PY - 2000/2/19/medline PY - 2000/1/13/entrez SP - 129 EP - 34 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 14 IS - 1 N2 - AIMS: To evaluate capsaicin's effects on heartburn, dyspepsia, gastric acidity and emptying, and gastro-oesophageal reflux, and to test the hypothesis that capsaicin induces heartburn and exacerbates symptoms by sensitizing the oesophagus. METHODS: Eleven heartburn sufferers underwent two separate pH monitoring sessions and assessments of gastric emptying (13C-octanoic acid breath test), heartburn and dyspepsia (100 mm VAS) after a non-irritant meal. The meal consisted of a sausage biscuit with egg, cheese and 30 g raw onion, 8 oz chocolate milk and a peppermint patty. Thirty minutes prior to meal consumption, subjects were administered a placebo capsule. On visit 1, subjects consumed the meal containing 100 microl 13C-octanoic acid cooked in the egg, over 15 min. On visit 2, subjects consumed the meal plus 5 mg capsaicin in gelatin capsules. RESULTS: Oesophageal and gastric pH profiles and gastric emptying were not different between meals. Capsaicin did not alter mean heartburn and dyspepsia scores (P > 0.05), but significantly decreased time to peak heartburn (120 min vs. 247 min; P < 0.003). Time to peak dyspepsia was not altered by capsaicin (P > 0.05). CONCLUSION: Capsaicin enhances noxious postprandial heartburn, presumably by direct effects on sensory neurons. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/10632656/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=2000&amp;volume=14&amp;issue=1&amp;spage=129 DB - PRIME DP - Unbound Medicine ER -