Tags

Type your tag names separated by a space and hit enter

High-frequency oscillatory ventilation in premature infants.
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Dec; 62(12):879-85.ZY

Abstract

BACKGROUND

Although assisted ventilation has reduced the mortality rate of premature infants, pulmonary disease is still the major cause of morbidity and mortality in very low birth weight infants. We designed this study to evaluate the efficacy and safety of high-frequency oscillatory ventilation (HFOV) in premature infants and to compare the outcome for early intervention with HFOV versus conventional ventilation (CV).

METHODS

From January, 1997, to June, 1998, we analyzed premature infants with respiratory failure who required mechanical ventilation and supplemental oxygen to support adequate gas exchange in our neonatal intensive care unit. Patients were eligible if their gestational age was less than 35 weeks or their birth weight was less than 1,751 g. A total of 35 neonates were enrolled in the study. Eighteen infants were treated with HFOV, and 17 infants were treated with CV. They were treated with early intervention of HFOV or CV, within 24 hours-of-age. Patients were excluded if a lethal congenital anomaly, bacteremia, hydrops fetalis, congenital diaphragmatic hernia or intubation only for apnea were noted. Data on demographics, gas exchange and outcome parameters were collected for each patient enrolled in the study.

RESULTS

No differences were noted in the demographic features between the study groups. All of the enrolled patients suffered from variable grades of respiratory distress syndrome. A significantly shorter intubation period was found in the HFOV group compared with the CV group (2.8 +/- 1.5 days vs 8.8 +/- 9.4 days; p = 0.013).

CONCLUSIONS

HFOV is a safe and effective therapy for premature infants with respiratory failure due to respiratory distress syndrome.

Authors+Show Affiliations

Lai MK
Department of Pediatrics, Children's Medical Center, Taipei Veterans General Hospital, Taiwan, ROC.
Jeng MJ
No affiliation info available
Soong WJ
No affiliation info available
Liu CW
No affiliation info available
Chen SJ
No affiliation info available
Hwang B
No affiliation info available

MeSH

FemaleHigh-Frequency VentilationHumansInfant, NewbornInfant, PrematureMaleRespiratory Insufficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10634002

Citation

Lai, M K., et al. "High-frequency Oscillatory Ventilation in Premature Infants." Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed, vol. 62, no. 12, 1999, pp. 879-85.
Lai MK, Jeng MJ, Soong WJ, et al. High-frequency oscillatory ventilation in premature infants. Zhonghua Yi Xue Za Zhi (Taipei). 1999;62(12):879-85.
Lai, M. K., Jeng, M. J., Soong, W. J., Liu, C. W., Chen, S. J., & Hwang, B. (1999). High-frequency oscillatory ventilation in premature infants. Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed, 62(12), 879-85.
Lai MK, et al. High-frequency Oscillatory Ventilation in Premature Infants. Zhonghua Yi Xue Za Zhi (Taipei). 1999;62(12):879-85. PubMed PMID: 10634002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-frequency oscillatory ventilation in premature infants. AU - Lai,M K, AU - Jeng,M J, AU - Soong,W J, AU - Liu,C W, AU - Chen,S J, AU - Hwang,B, PY - 2000/1/14/pubmed PY - 2000/1/14/medline PY - 2000/1/14/entrez SP - 879 EP - 85 JF - Zhonghua yi xue za zhi = Chinese medical journal; Free China ed JO - Zhonghua Yi Xue Za Zhi (Taipei) VL - 62 IS - 12 N2 - BACKGROUND: Although assisted ventilation has reduced the mortality rate of premature infants, pulmonary disease is still the major cause of morbidity and mortality in very low birth weight infants. We designed this study to evaluate the efficacy and safety of high-frequency oscillatory ventilation (HFOV) in premature infants and to compare the outcome for early intervention with HFOV versus conventional ventilation (CV). METHODS: From January, 1997, to June, 1998, we analyzed premature infants with respiratory failure who required mechanical ventilation and supplemental oxygen to support adequate gas exchange in our neonatal intensive care unit. Patients were eligible if their gestational age was less than 35 weeks or their birth weight was less than 1,751 g. A total of 35 neonates were enrolled in the study. Eighteen infants were treated with HFOV, and 17 infants were treated with CV. They were treated with early intervention of HFOV or CV, within 24 hours-of-age. Patients were excluded if a lethal congenital anomaly, bacteremia, hydrops fetalis, congenital diaphragmatic hernia or intubation only for apnea were noted. Data on demographics, gas exchange and outcome parameters were collected for each patient enrolled in the study. RESULTS: No differences were noted in the demographic features between the study groups. All of the enrolled patients suffered from variable grades of respiratory distress syndrome. A significantly shorter intubation period was found in the HFOV group compared with the CV group (2.8 +/- 1.5 days vs 8.8 +/- 9.4 days; p = 0.013). CONCLUSIONS: HFOV is a safe and effective therapy for premature infants with respiratory failure due to respiratory distress syndrome. SN - 0578-1337 UR - https://www.unboundmedicine.com/medline/citation/10634002/High_frequency_oscillatory_ventilation_in_premature_infants_ DB - PRIME DP - Unbound Medicine ER -