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The prevalence of celiac disease in at-risk groups of children in the United States.

Abstract

OBJECTIVE

In contrast to its prevalence in Europe, celiac disease (CD) is considered rare in the United States. We aimed to determine the prevalence of CD in children presenting with symptoms or conditions associated with CD.

STUDY DESIGN

Individuals aged 6 months to 20 years were screened for IgG and IgA antigliadin (AGA-IgG and AGA-IgA) and antiendomysium (EMA) antibodies. Those with only elevated AGA-IgG were screened for selective IgA deficiency. Patients with elevated EMA, or AGA-IgG elevation and selective IgA deficiency, were advised to undergo small intestinal biopsy.

RESULTS

A total of 1200 individuals were studied; 34 were EMA positive-26 (19 EMA positive) consented to biopsy and 21 had CD, giving a prevalence of 1 in 57 (21/1200). Including the 15 EMA positive patients who refused a biopsy, the prevalence of CD in this study could be as high as 1 in 33 (36/1200).

CONCLUSIONS

CD is not rare in the United States and may be as common as in Europe. AGA and EMA are useful for identifying patients who should undergo a small intestinal biopsy.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Pediatric Gastroenterology and Nutrition, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

    , , , ,

    Source

    The Journal of pediatrics 136:1 2000 Jan pg 86-90

    MeSH

    Adolescent
    Adult
    Antibodies
    Biopsy
    Celiac Disease
    Child
    Child, Preschool
    Dysgammaglobulinemia
    Europe
    Follow-Up Studies
    Gliadin
    Humans
    IgA Deficiency
    Immunoglobulin A
    Immunoglobulin G
    Infant
    Intestine, Small
    Mass Screening
    Myofibrils
    Risk Factors
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10636980

    Citation

    Hill, I, et al. "The Prevalence of Celiac Disease in At-risk Groups of Children in the United States." The Journal of Pediatrics, vol. 136, no. 1, 2000, pp. 86-90.
    Hill I, Fasano A, Schwartz R, et al. The prevalence of celiac disease in at-risk groups of children in the United States. J Pediatr. 2000;136(1):86-90.
    Hill, I., Fasano, A., Schwartz, R., Counts, D., Glock, M., & Horvath, K. (2000). The prevalence of celiac disease in at-risk groups of children in the United States. The Journal of Pediatrics, 136(1), pp. 86-90.
    Hill I, et al. The Prevalence of Celiac Disease in At-risk Groups of Children in the United States. J Pediatr. 2000;136(1):86-90. PubMed PMID: 10636980.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The prevalence of celiac disease in at-risk groups of children in the United States. AU - Hill,I, AU - Fasano,A, AU - Schwartz,R, AU - Counts,D, AU - Glock,M, AU - Horvath,K, PY - 2000/1/15/pubmed PY - 2000/2/19/medline PY - 2000/1/15/entrez SP - 86 EP - 90 JF - The Journal of pediatrics JO - J. Pediatr. VL - 136 IS - 1 N2 - OBJECTIVE: In contrast to its prevalence in Europe, celiac disease (CD) is considered rare in the United States. We aimed to determine the prevalence of CD in children presenting with symptoms or conditions associated with CD. STUDY DESIGN: Individuals aged 6 months to 20 years were screened for IgG and IgA antigliadin (AGA-IgG and AGA-IgA) and antiendomysium (EMA) antibodies. Those with only elevated AGA-IgG were screened for selective IgA deficiency. Patients with elevated EMA, or AGA-IgG elevation and selective IgA deficiency, were advised to undergo small intestinal biopsy. RESULTS: A total of 1200 individuals were studied; 34 were EMA positive-26 (19 EMA positive) consented to biopsy and 21 had CD, giving a prevalence of 1 in 57 (21/1200). Including the 15 EMA positive patients who refused a biopsy, the prevalence of CD in this study could be as high as 1 in 33 (36/1200). CONCLUSIONS: CD is not rare in the United States and may be as common as in Europe. AGA and EMA are useful for identifying patients who should undergo a small intestinal biopsy. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/10636980/The_prevalence_of_celiac_disease_in_at_risk_groups_of_children_in_the_United_States_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(00)90055-6 DB - PRIME DP - Unbound Medicine ER -