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[Ocular pulse amplitude, intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma].
Klin Monbl Augenheilkd. 1999 Dec; 215(6):361-6.KM

Abstract

BACKGROUND

Beyond intraocular pressure (IOP, German abbreviation: IOD) ocular perfusion is increasingly discussed in the pathogenesis of the glaucomas. The present study was designed to investigate for ocular pulse amplitude (OPA) in primary open angle glaucoma patients with elevated intraocular pressure (POAG, German abbreviation: POWG) following application of timolol, a beta-blocker and dorzolamide a topical carbonic anhydrase inhibitor.

METHODS

OPA (Ocular Blood Flow System, OBF Labs U.K.) IOP, heart rate, systolic and diastolic brachial artery pressures were measured before and 4 weeks following application of timolol and additional 4 weeks following application of a timolol/dorzolamide combination in 14 POAG patients.

RESULTS

Following administration of timolol, IOP was highly significantly reduced in drug treated POAG eyes; this effect was additively enhanced by dorzolamide. Timolol did not affect OPA, whereas dorzolamide significantly increased OPA in drug treated POAG eyes. Systemic perfusion parameters were unchanged.

CONCLUSION

Timolol and dorzolamide drastically reduced IOP, in addition dorzolamide increased OPA in POAG, an ocular microcirculatory effect which may further help to improve prognosis of POAG.

Links

Publisher Full Text

Authors+Show Affiliations

Schmidt KG
Univ.-Augenklinik, Giessen.
von Rückmann A
No affiliation info available
Becker R
No affiliation info available
Pillunat LE
No affiliation info available

MeSH

Adrenergic beta-AntagonistsAgedBlood PressureCarbonic Anhydrase InhibitorsDrug Therapy, CombinationEyeFemaleGlaucoma, Open-AngleHumansIntraocular PressureMaleMiddle AgedOphthalmic SolutionsPulsatile FlowSulfonamidesThiophenesTimolol

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

10637801

Citation

Schmidt, K G., et al. "[Ocular Pulse Amplitude, Intraocular Pressure and Beta Blocker/carbonic Anhydrase Inhibition in Combined Therapy of Primary Open-angle Glaucoma]." Klinische Monatsblatter Fur Augenheilkunde, vol. 215, no. 6, 1999, pp. 361-6.
Schmidt KG, von Rückmann A, Becker R, et al. [Ocular pulse amplitude, intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma]. Klin Monbl Augenheilkd. 1999;215(6):361-6.
Schmidt, K. G., von Rückmann, A., Becker, R., & Pillunat, L. E. (1999). [Ocular pulse amplitude, intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma]. Klinische Monatsblatter Fur Augenheilkunde, 215(6), 361-6.
Schmidt KG, et al. [Ocular Pulse Amplitude, Intraocular Pressure and Beta Blocker/carbonic Anhydrase Inhibition in Combined Therapy of Primary Open-angle Glaucoma]. Klin Monbl Augenheilkd. 1999;215(6):361-6. PubMed PMID: 10637801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Ocular pulse amplitude, intraocular pressure and beta blocker/carbonic anhydrase inhibition in combined therapy of primary open-angle glaucoma]. AU - Schmidt,K G, AU - von Rückmann,A, AU - Becker,R, AU - Pillunat,L E, PY - 2000/1/19/pubmed PY - 2000/2/26/medline PY - 2000/1/19/entrez SP - 361 EP - 6 JF - Klinische Monatsblatter fur Augenheilkunde JO - Klin Monbl Augenheilkd VL - 215 IS - 6 N2 - BACKGROUND: Beyond intraocular pressure (IOP, German abbreviation: IOD) ocular perfusion is increasingly discussed in the pathogenesis of the glaucomas. The present study was designed to investigate for ocular pulse amplitude (OPA) in primary open angle glaucoma patients with elevated intraocular pressure (POAG, German abbreviation: POWG) following application of timolol, a beta-blocker and dorzolamide a topical carbonic anhydrase inhibitor. METHODS: OPA (Ocular Blood Flow System, OBF Labs U.K.) IOP, heart rate, systolic and diastolic brachial artery pressures were measured before and 4 weeks following application of timolol and additional 4 weeks following application of a timolol/dorzolamide combination in 14 POAG patients. RESULTS: Following administration of timolol, IOP was highly significantly reduced in drug treated POAG eyes; this effect was additively enhanced by dorzolamide. Timolol did not affect OPA, whereas dorzolamide significantly increased OPA in drug treated POAG eyes. Systemic perfusion parameters were unchanged. CONCLUSION: Timolol and dorzolamide drastically reduced IOP, in addition dorzolamide increased OPA in POAG, an ocular microcirculatory effect which may further help to improve prognosis of POAG. SN - 0023-2165 UR - https://www.unboundmedicine.com/medline/citation/10637801/[Ocular_pulse_amplitude_intraocular_pressure_and_beta_blocker/carbonic_anhydrase_inhibition_in_combined_therapy_of_primary_open_angle_glaucoma]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1034733 DB - PRIME DP - Unbound Medicine ER -