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The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country.
Am J Gastroenterol. 2000 Jan; 95(1):50-6.AJ

Abstract

OBJECTIVE

The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) eradication on the natural history of duodenal ulcer disease and the reinfection rate after treatment in a developing country.

METHODS

A total of 111 H. pylori-infected patients with duodenal ulcer were treated with either omeprazole or famotidine plus two antibiotics for 2 wk. Those failed to respond to treatment were retreated with bismuth-based triple therapy.

RESULTS

The radication rate was 76% (95% CI: 67-83%). Eventually, H. pylori was eradicated in 96 of the 111 patients (86%), who were followed-up clinically and endoscopically for a mean of 37.2 months. The cumulative reinfection rate after eradication (Kaplan-Meier) was 8%+/-3% in yr 1, 11%+/-4% in yr 2, and 13%+/-4% in yr 3. Nine of the 12 reinfections occurred during yr 1. Recurrence of duodenal ulcer was detected in five patients (5.2%), all of them during yr 1 of follow-up. Histologically, gastritis scores (according to the Sydney system) improved significantly after eradication.

CONCLUSIONS

In a high prevalence setting, H. pylori eradication and early reinfection rates after treatment are similar to rates observed in a low prevalence environment, whereas the late reinfection rate seems to be higher. However, up to 3 yr after treatment, most treated patients are free of H. pylori infection and/or ulcer activity. Even longer follow-up studies are necessary to determine whether specific retreatment policies are necessary to maintain long term eradication in developing countries.

Authors+Show Affiliations

Department of Gastroenterology and Pathology, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10638558

Citation

Rollan, A, et al. "The Long-term Reinfection Rate and the Course of Duodenal Ulcer Disease After Eradication of Helicobacter Pylori in a Developing Country." The American Journal of Gastroenterology, vol. 95, no. 1, 2000, pp. 50-6.
Rollan A, Giancaspero R, Fuster F, et al. The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country. Am J Gastroenterol. 2000;95(1):50-6.
Rollan, A., Giancaspero, R., Fuster, F., Acevedo, C., Figueroa, C., Hola, K., Schulz, M., & Duarte, I. (2000). The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country. The American Journal of Gastroenterology, 95(1), 50-6.
Rollan A, et al. The Long-term Reinfection Rate and the Course of Duodenal Ulcer Disease After Eradication of Helicobacter Pylori in a Developing Country. Am J Gastroenterol. 2000;95(1):50-6. PubMed PMID: 10638558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The long-term reinfection rate and the course of duodenal ulcer disease after eradication of Helicobacter pylori in a developing country. AU - Rollan,A, AU - Giancaspero,R, AU - Fuster,F, AU - Acevedo,C, AU - Figueroa,C, AU - Hola,K, AU - Schulz,M, AU - Duarte,I, PY - 2000/1/19/pubmed PY - 2000/1/19/medline PY - 2000/1/19/entrez SP - 50 EP - 6 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 95 IS - 1 N2 - OBJECTIVE: The aim of this study was to evaluate the effect of Helicobacter pylori (H. pylori) eradication on the natural history of duodenal ulcer disease and the reinfection rate after treatment in a developing country. METHODS: A total of 111 H. pylori-infected patients with duodenal ulcer were treated with either omeprazole or famotidine plus two antibiotics for 2 wk. Those failed to respond to treatment were retreated with bismuth-based triple therapy. RESULTS: The radication rate was 76% (95% CI: 67-83%). Eventually, H. pylori was eradicated in 96 of the 111 patients (86%), who were followed-up clinically and endoscopically for a mean of 37.2 months. The cumulative reinfection rate after eradication (Kaplan-Meier) was 8%+/-3% in yr 1, 11%+/-4% in yr 2, and 13%+/-4% in yr 3. Nine of the 12 reinfections occurred during yr 1. Recurrence of duodenal ulcer was detected in five patients (5.2%), all of them during yr 1 of follow-up. Histologically, gastritis scores (according to the Sydney system) improved significantly after eradication. CONCLUSIONS: In a high prevalence setting, H. pylori eradication and early reinfection rates after treatment are similar to rates observed in a low prevalence environment, whereas the late reinfection rate seems to be higher. However, up to 3 yr after treatment, most treated patients are free of H. pylori infection and/or ulcer activity. Even longer follow-up studies are necessary to determine whether specific retreatment policies are necessary to maintain long term eradication in developing countries. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/10638558/The_long_term_reinfection_rate_and_the_course_of_duodenal_ulcer_disease_after_eradication_of_Helicobacter_pylori_in_a_developing_country_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-9270&date=2000&volume=95&issue=1&spage=50 DB - PRIME DP - Unbound Medicine ER -