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Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review.
J Am Acad Dermatol. 2000 Feb; 42(2 Pt 2):357-62.JA

Abstract

The association of acanthosis nigricans (AN) with the sign of Leser-Trélat (LT) and gastric carcinoma is rare. Our patient was a 69-year-old man, who presented with hematemesis; a stage-IV poorly differentiated, diffuse-type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, with florid cutaneous papillomatosis that also involved the mucous membranes of the mouth and eyelids, and keratoderma. AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena. The patient died 7 months after completion of chemotherapy. The coexistence of AN and the sign of LT should prompt a search for underlying malignancy. The pathogenesis of both dermatoses is discussed.

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Authors+Show Affiliations

Yeh JS
Department of Dermatology, King's College Hospital, London, United Kingdom.
Munn SE
No affiliation info available
Plunkett TA
No affiliation info available
Harper PG
No affiliation info available
Hopster DJ
No affiliation info available
du Vivier AW
No affiliation info available

MeSH

Acanthosis NigricansAdenocarcinomaAgedFatal OutcomeGastric MucosaHumansKeratosis, SeborrheicMaleMouth MucosaSkinStomach Neoplasms

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10640933

Citation

Yeh, J S., et al. "Coexistence of Acanthosis Nigricans and the Sign of Leser-Trélat in a Patient With Gastric Adenocarcinoma: a Case Report and Literature Review." Journal of the American Academy of Dermatology, vol. 42, no. 2 Pt 2, 2000, pp. 357-62.
Yeh JS, Munn SE, Plunkett TA, et al. Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review. J Am Acad Dermatol. 2000;42(2 Pt 2):357-62.
Yeh, J. S., Munn, S. E., Plunkett, T. A., Harper, P. G., Hopster, D. J., & du Vivier, A. W. (2000). Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review. Journal of the American Academy of Dermatology, 42(2 Pt 2), 357-62.
Yeh JS, et al. Coexistence of Acanthosis Nigricans and the Sign of Leser-Trélat in a Patient With Gastric Adenocarcinoma: a Case Report and Literature Review. J Am Acad Dermatol. 2000;42(2 Pt 2):357-62. PubMed PMID: 10640933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coexistence of acanthosis nigricans and the sign of Leser-Trélat in a patient with gastric adenocarcinoma: a case report and literature review. AU - Yeh,J S, AU - Munn,S E, AU - Plunkett,T A, AU - Harper,P G, AU - Hopster,D J, AU - du Vivier,A W, PY - 2000/1/21/pubmed PY - 2000/2/26/medline PY - 2000/1/21/entrez SP - 357 EP - 62 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 42 IS - 2 Pt 2 N2 - The association of acanthosis nigricans (AN) with the sign of Leser-Trélat (LT) and gastric carcinoma is rare. Our patient was a 69-year-old man, who presented with hematemesis; a stage-IV poorly differentiated, diffuse-type, adenocarcinoma of the gastric antrum was diagnosed. The AN was striking, with florid cutaneous papillomatosis that also involved the mucous membranes of the mouth and eyelids, and keratoderma. AN and the sign of LT predated tumor detection by 6 months and regressed after chemotherapy in parallel with reduction of the tumor load, demonstrating the dermatoses as paraneoplastic phenomena. The patient died 7 months after completion of chemotherapy. The coexistence of AN and the sign of LT should prompt a search for underlying malignancy. The pathogenesis of both dermatoses is discussed. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/10640933/Coexistence_of_acanthosis_nigricans_and_the_sign_of_Leser_Trélat_in_a_patient_with_gastric_adenocarcinoma:_a_case_report_and_literature_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(00)90112-9 DB - PRIME DP - Unbound Medicine ER -