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Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels.
Int J Hematol. 1999 Jan; 69(1):43-7.IJ

Abstract

Plasminogen activator inhibitor-1 (PAI-1) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases. The gene for PAI-1 has an insertion/deletion polymorphism at the promoter region, the 4G/5G polymorphism, which is related to differences in transcription activity in vitro. Association of the 4G/5G polymorphism with plasma PAI-1 levels, however, has not been uniformly reported. We evaluated the relationship between the 4G/5G polymorphism and plasma PAI-1 antigen levels in 104 Japanese males not taking lipid-lowering drugs and without non-insulin-dependent (type 2) diabetes mellitus or coronary artery disease. The genotype frequency was 37.5%, 50.0%, and 12.5% for 4G/4G, 4G/5G, and 5G/5G genotypes, respectively, which differs from that reported for healthy Caucasian males (P < 0.01), with the 4G allele more frequently found in the Japanese population. No association was found between the 4G/5G polymorphism and plasma PAI-1 antigen levels. Multiple regression analysis revealed a significant (P < 0.01) contribution of triglyceride (TG) levels to variations in plasma PAI-1 antigen levels. The correlation between TG levels and plasma PAI-1 antigen levels was not 4G/5G genotype-specific. These findings suggest that PAI-1 4G/5G polymorphism is not associated with plasma PAI-1 antigen levels among healthy Japanese males and that TG levels correlate to plasma PAI-1 antigen levels in all PAI-1 4G/5G genotypes.

Authors+Show Affiliations

Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10641442

Citation

Matsubara, Y, et al. "Genotype Frequency of Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G Polymorphism in Healthy Japanese Males and Its Relation to PAI-1 Levels." International Journal of Hematology, vol. 69, no. 1, 1999, pp. 43-7.
Matsubara Y, Murata M, Isshiki I, et al. Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels. Int J Hematol. 1999;69(1):43-7.
Matsubara, Y., Murata, M., Isshiki, I., Watanabe, R., Zama, T., Watanabe, G., Watanabe, K., & Ikeda, Y. (1999). Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels. International Journal of Hematology, 69(1), 43-7.
Matsubara Y, et al. Genotype Frequency of Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G Polymorphism in Healthy Japanese Males and Its Relation to PAI-1 Levels. Int J Hematol. 1999;69(1):43-7. PubMed PMID: 10641442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genotype frequency of plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in healthy Japanese males and its relation to PAI-1 levels. AU - Matsubara,Y, AU - Murata,M, AU - Isshiki,I, AU - Watanabe,R, AU - Zama,T, AU - Watanabe,G, AU - Watanabe,K, AU - Ikeda,Y, PY - 2000/1/21/pubmed PY - 2000/2/19/medline PY - 2000/1/21/entrez SP - 43 EP - 7 JF - International journal of hematology JO - Int J Hematol VL - 69 IS - 1 N2 - Plasminogen activator inhibitor-1 (PAI-1) plays an inhibitory role in the fibrinolytic enzyme system and is associated with thrombotic diseases. The gene for PAI-1 has an insertion/deletion polymorphism at the promoter region, the 4G/5G polymorphism, which is related to differences in transcription activity in vitro. Association of the 4G/5G polymorphism with plasma PAI-1 levels, however, has not been uniformly reported. We evaluated the relationship between the 4G/5G polymorphism and plasma PAI-1 antigen levels in 104 Japanese males not taking lipid-lowering drugs and without non-insulin-dependent (type 2) diabetes mellitus or coronary artery disease. The genotype frequency was 37.5%, 50.0%, and 12.5% for 4G/4G, 4G/5G, and 5G/5G genotypes, respectively, which differs from that reported for healthy Caucasian males (P < 0.01), with the 4G allele more frequently found in the Japanese population. No association was found between the 4G/5G polymorphism and plasma PAI-1 antigen levels. Multiple regression analysis revealed a significant (P < 0.01) contribution of triglyceride (TG) levels to variations in plasma PAI-1 antigen levels. The correlation between TG levels and plasma PAI-1 antigen levels was not 4G/5G genotype-specific. These findings suggest that PAI-1 4G/5G polymorphism is not associated with plasma PAI-1 antigen levels among healthy Japanese males and that TG levels correlate to plasma PAI-1 antigen levels in all PAI-1 4G/5G genotypes. SN - 0925-5710 UR - https://www.unboundmedicine.com/medline/citation/10641442/Genotype_frequency_of_plasminogen_activator_inhibitor_1__PAI_1__4G/5G_polymorphism_in_healthy_Japanese_males_and_its_relation_to_PAI_1_levels_ DB - PRIME DP - Unbound Medicine ER -