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The vagus and gastrin components in peripheral blood.
Scand J Gastroenterol Suppl. 1976; 37:77-80.SJ

Abstract

To study the role played by vagal activity for the gastrins in peripheral blood, the mean pattern during feeding was studied in 16 duodenal ulcer patients before and after selective (n=8), or truncal vagotomy (n=8). Two normal subjects were studied with and without atropine during hypoglycaemic activation of the vagus. Gastrins were fractionated by gel chromatography. Serum gastrin was almost exclusively made up of gastrin component II (gastrin 34-like) and III (gastrin 17-like). Both components rose after feeding but the major increase was incomponent III. Total gastrin concentrations rose after vagotomy but no qualitative changes were seen. During hypoglycaemia a marked increase in gastrin component III and a lesser increase in component II was found. This pattern was not changed by atropine. It is concluded that the vagus plays little or no role for a selective release of the various gastrins. Furthermore there is no indication that the higher serum levels after vagotomy consist of gastrins of a lesser biological activity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1064145

Citation

Stadil, F, et al. "The Vagus and Gastrin Components in Peripheral Blood." Scandinavian Journal of Gastroenterology. Supplement, vol. 37, 1976, pp. 77-80.
Stadil F, Malmström J, Christensen KC. The vagus and gastrin components in peripheral blood. Scand J Gastroenterol Suppl. 1976;37:77-80.
Stadil, F., Malmström, J., & Christensen, K. C. (1976). The vagus and gastrin components in peripheral blood. Scandinavian Journal of Gastroenterology. Supplement, 37, 77-80.
Stadil F, Malmström J, Christensen KC. The Vagus and Gastrin Components in Peripheral Blood. Scand J Gastroenterol Suppl. 1976;37:77-80. PubMed PMID: 1064145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The vagus and gastrin components in peripheral blood. AU - Stadil,F, AU - Malmström,J, AU - Christensen,K C, PY - 1976/1/1/pubmed PY - 1976/1/1/medline PY - 1976/1/1/entrez SP - 77 EP - 80 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand J Gastroenterol Suppl VL - 37 N2 - To study the role played by vagal activity for the gastrins in peripheral blood, the mean pattern during feeding was studied in 16 duodenal ulcer patients before and after selective (n=8), or truncal vagotomy (n=8). Two normal subjects were studied with and without atropine during hypoglycaemic activation of the vagus. Gastrins were fractionated by gel chromatography. Serum gastrin was almost exclusively made up of gastrin component II (gastrin 34-like) and III (gastrin 17-like). Both components rose after feeding but the major increase was incomponent III. Total gastrin concentrations rose after vagotomy but no qualitative changes were seen. During hypoglycaemia a marked increase in gastrin component III and a lesser increase in component II was found. This pattern was not changed by atropine. It is concluded that the vagus plays little or no role for a selective release of the various gastrins. Furthermore there is no indication that the higher serum levels after vagotomy consist of gastrins of a lesser biological activity. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/1064145/The_vagus_and_gastrin_components_in_peripheral_blood_ DB - PRIME DP - Unbound Medicine ER -
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