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The failure of granulocytes to produce transcobalamin I TC I.
Scand J Haematol. 1976 Mar; 16(3):176-82.SJ

Abstract

The hypothesis that transcobalamin I (TC I) originates from granulocytes was tested by comparing the isoelectric focusing (IEF) patterns of the R-type binder (cobalophilin) of vitamin B12 of: 1) lysed granulocytes, 2) 24 h granulocyte output, and 3) plasma. The preparations came from the blood of 5 normal subjects and 4 with myeloproliferative states. The cobalophilin released into a culture of granulocytes resembled the binder in the granulocytes initially. TC I, defined as the alpha1 cobalophilin with components isoelectric between pH 2.9-3.35 and as a carrier of native plasma B12, was not released by granulocytes. The granulocyte binder of leukaemic granulocytes did not differ from the normal in content per cell or amount released.

Authors

Hall CA
No affiliation info available

MeSH

Blood ProteinsCells, CulturedGranulocytesHumansIsoelectric FocusingLeukemiaLeukemia, MyeloidLeukocytesPrimary MyelofibrosisTranscobalaminsVitamin B 12

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

1064150

Citation

Hall, C A.. "The Failure of Granulocytes to Produce Transcobalamin I TC I." Scandinavian Journal of Haematology, vol. 16, no. 3, 1976, pp. 176-82.
Hall CA. The failure of granulocytes to produce transcobalamin I TC I. Scand J Haematol. 1976;16(3):176-82.
Hall, C. A. (1976). The failure of granulocytes to produce transcobalamin I TC I. Scandinavian Journal of Haematology, 16(3), 176-82.
Hall CA. The Failure of Granulocytes to Produce Transcobalamin I TC I. Scand J Haematol. 1976;16(3):176-82. PubMed PMID: 1064150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The failure of granulocytes to produce transcobalamin I TC I. A1 - Hall,C A, PY - 1976/3/1/pubmed PY - 1976/3/1/medline PY - 1976/3/1/entrez SP - 176 EP - 82 JF - Scandinavian journal of haematology JO - Scand J Haematol VL - 16 IS - 3 N2 - The hypothesis that transcobalamin I (TC I) originates from granulocytes was tested by comparing the isoelectric focusing (IEF) patterns of the R-type binder (cobalophilin) of vitamin B12 of: 1) lysed granulocytes, 2) 24 h granulocyte output, and 3) plasma. The preparations came from the blood of 5 normal subjects and 4 with myeloproliferative states. The cobalophilin released into a culture of granulocytes resembled the binder in the granulocytes initially. TC I, defined as the alpha1 cobalophilin with components isoelectric between pH 2.9-3.35 and as a carrier of native plasma B12, was not released by granulocytes. The granulocyte binder of leukaemic granulocytes did not differ from the normal in content per cell or amount released. SN - 0036-553X UR - https://www.unboundmedicine.com/medline/citation/1064150/The_failure_of_granulocytes_to_produce_transcobalamin_I_TC_I_ DB - PRIME DP - Unbound Medicine ER -