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Endoscopic treatments for portal hypertension.
Semin Liver Dis. 1999; 19(4):439-55.SL

Abstract

Endoscopic treatments for bleeding gastroesophageal varices include injection sclerotherapy, variceal obturation with tissue adhesives, and variceal rubber band ligation. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from esophageal varices. Although few trials have been published so far, some evidence suggests that the early administration of vasoactive drugs (somatostatin, octreotide, or terlipressin) is safe and may increase the efficacy of endoscopic treatments. Banding ligation is the optimal endoscopic treatment for the prevention of rebleeding from esophageal varices. The use of tissue adhesives and thrombin as injectates to treat bleeding fundal gastric varices and esophageal varices not responding to vasoactive drugs or sclerotherapy is promising but needs further assessment by means of randomized controlled trials. As of today, endoscopic treatments are not recommended for the primary prophylaxis of variceal bleeding.

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Authors+Show Affiliations

de Franchis R
Dipartimento di Medicina Interna, University of Milan, Italy. deFranchis@planet.it
Primignani M
No affiliation info available

MeSH

Acute DiseaseAnimalsCatheterizationEndoscopyEsophageal and Gastric VaricesGastrointestinal HemorrhageHumansHypertension, PortalLigationSclerotherapyTissue Adhesives

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10643628

Clinical Trial Links

Predictive Factors and Outcome of Esophageal Ulcers After Endoscopic Treatment of Esophageal Varices

Citation

de Franchis, R, and M Primignani. "Endoscopic Treatments for Portal Hypertension." Seminars in Liver Disease, vol. 19, no. 4, 1999, pp. 439-55.
de Franchis R, Primignani M. Endoscopic treatments for portal hypertension. Semin Liver Dis. 1999;19(4):439-55.
de Franchis, R., & Primignani, M. (1999). Endoscopic treatments for portal hypertension. Seminars in Liver Disease, 19(4), 439-55.
de Franchis R, Primignani M. Endoscopic Treatments for Portal Hypertension. Semin Liver Dis. 1999;19(4):439-55. PubMed PMID: 10643628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endoscopic treatments for portal hypertension. AU - de Franchis,R, AU - Primignani,M, PY - 2000/1/22/pubmed PY - 2000/1/22/medline PY - 2000/1/22/entrez SP - 439 EP - 55 JF - Seminars in liver disease JO - Semin Liver Dis VL - 19 IS - 4 N2 - Endoscopic treatments for bleeding gastroesophageal varices include injection sclerotherapy, variceal obturation with tissue adhesives, and variceal rubber band ligation. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from esophageal varices. Although few trials have been published so far, some evidence suggests that the early administration of vasoactive drugs (somatostatin, octreotide, or terlipressin) is safe and may increase the efficacy of endoscopic treatments. Banding ligation is the optimal endoscopic treatment for the prevention of rebleeding from esophageal varices. The use of tissue adhesives and thrombin as injectates to treat bleeding fundal gastric varices and esophageal varices not responding to vasoactive drugs or sclerotherapy is promising but needs further assessment by means of randomized controlled trials. As of today, endoscopic treatments are not recommended for the primary prophylaxis of variceal bleeding. SN - 0272-8087 UR - https://www.unboundmedicine.com/medline/citation/10643628/Endoscopic_treatments_for_portal_hypertension_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-1007131 DB - PRIME DP - Unbound Medicine ER -