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Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population.

Abstract

We compared the distribution of an insertion (I)/deletion (D) polymorphism of the gene coding for the angiotensin-converting enzyme (ACE) in 133 Japanese sporadic Alzheimer disease (AD) patients with 257 controls. The association between AD and ACE genotypes or alleles was found to be significant. The frequency of II genotypes was 1.4 times higher in AD than controls, while that of DD genotypes was only 0.4 times as high. The altered distribution of ACE alleles in patients with AD appeared to be independent of apolipoprotein E.

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  • Authors+Show Affiliations

    ,

    R&D Center, BML Inc., Kawagoe, Saitama, Japan. hu@alk.co.jp

    , , , , , , ,

    Source

    Neuroscience letters 277:1 1999 Dec 17 pg 65-7

    MeSH

    Aged
    Alzheimer Disease
    Brain Chemistry
    Gene Frequency
    Genotype
    Humans
    Japan
    Peptidyl-Dipeptidase A
    Polymorphism, Genetic
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    10643899

    Citation

    Hu, J, et al. "Angiotensin-converting Enzyme Genotype Is Associated With Alzheimer Disease in the Japanese Population." Neuroscience Letters, vol. 277, no. 1, 1999, pp. 65-7.
    Hu J, Miyatake F, Aizu Y, et al. Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. Neurosci Lett. 1999;277(1):65-7.
    Hu, J., Miyatake, F., Aizu, Y., Nakagawa, H., Nakamura, S., Tamaoka, A., ... Shoji, M. (1999). Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. Neuroscience Letters, 277(1), pp. 65-7.
    Hu J, et al. Angiotensin-converting Enzyme Genotype Is Associated With Alzheimer Disease in the Japanese Population. Neurosci Lett. 1999 Dec 17;277(1):65-7. PubMed PMID: 10643899.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population. AU - Hu,J, AU - Miyatake,F, AU - Aizu,Y, AU - Nakagawa,H, AU - Nakamura,S, AU - Tamaoka,A, AU - Takahash,R, AU - Urakami,K, AU - Shoji,M, PY - 2000/1/22/pubmed PY - 2000/2/19/medline PY - 2000/1/22/entrez SP - 65 EP - 7 JF - Neuroscience letters JO - Neurosci. Lett. VL - 277 IS - 1 N2 - We compared the distribution of an insertion (I)/deletion (D) polymorphism of the gene coding for the angiotensin-converting enzyme (ACE) in 133 Japanese sporadic Alzheimer disease (AD) patients with 257 controls. The association between AD and ACE genotypes or alleles was found to be significant. The frequency of II genotypes was 1.4 times higher in AD than controls, while that of DD genotypes was only 0.4 times as high. The altered distribution of ACE alleles in patients with AD appeared to be independent of apolipoprotein E. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/10643899/Angiotensin_converting_enzyme_genotype_is_associated_with_Alzheimer_disease_in_the_Japanese_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(99)00827-7 DB - PRIME DP - Unbound Medicine ER -