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Telomerase activity in thyroid malignancy.
Thyroid. 1999 Dec; 9(12):1215-20.T

Abstract

Telomerase activity seems to play a role in the development and pathogenesis of thyroid carcinoma. Its incidence of expression and its application as a tumor marker remain to be elucidated. Thyroid tissues obtained during thyroidectomy from 1996-1998 were rapidly frozen and stored at -80 degrees C until processed. Telomerase activity was determined using telomeric repeat amplification protocol (TRAP). Histology of the tissue examined (67 benign and 59 malignant) was reviewed. Telomerase activity was detected in 15 of 52 papillary carcinomas (29%); 1 of 1 thyroid lymphoma (100%); 1 of 2 anaplastic carcinomas (50%); and 2 of 16 lymphocytic thyroiditis specimens (13%). Telomerase activity was not detectable in 35 normal thyroid, 9 follicular adenoma, 7 nodular hyperplasia, 2 follicular carcinoma, and 2 medullary carcinoma. Lymphocytic thyroiditis was detected in 8 of 37 (22%) apparently normal thyroid tissues adjacent to papillary thyroid carcinoma and telomerase activity was present in 2 of these 8 specimens (25%). In conclusion, telomerase does not appear to be frequently activated in papillary thyroid carcinoma. The association of lymphocytic thyroiditis with papillary thyroid carcinoma may limit its clinical usefulness as a tumor marker.

Authors+Show Affiliations

Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, China. cylo@hkucc.hku.hkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10646661

Citation

Lo, C Y., et al. "Telomerase Activity in Thyroid Malignancy." Thyroid : Official Journal of the American Thyroid Association, vol. 9, no. 12, 1999, pp. 1215-20.
Lo CY, Lam KY, Chan KT, et al. Telomerase activity in thyroid malignancy. Thyroid. 1999;9(12):1215-20.
Lo, C. Y., Lam, K. Y., Chan, K. T., & Luk, J. M. (1999). Telomerase activity in thyroid malignancy. Thyroid : Official Journal of the American Thyroid Association, 9(12), 1215-20.
Lo CY, et al. Telomerase Activity in Thyroid Malignancy. Thyroid. 1999;9(12):1215-20. PubMed PMID: 10646661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity in thyroid malignancy. AU - Lo,C Y, AU - Lam,K Y, AU - Chan,K T, AU - Luk,J M, PY - 2000/1/26/pubmed PY - 2000/1/26/medline PY - 2000/1/26/entrez SP - 1215 EP - 20 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 9 IS - 12 N2 - Telomerase activity seems to play a role in the development and pathogenesis of thyroid carcinoma. Its incidence of expression and its application as a tumor marker remain to be elucidated. Thyroid tissues obtained during thyroidectomy from 1996-1998 were rapidly frozen and stored at -80 degrees C until processed. Telomerase activity was determined using telomeric repeat amplification protocol (TRAP). Histology of the tissue examined (67 benign and 59 malignant) was reviewed. Telomerase activity was detected in 15 of 52 papillary carcinomas (29%); 1 of 1 thyroid lymphoma (100%); 1 of 2 anaplastic carcinomas (50%); and 2 of 16 lymphocytic thyroiditis specimens (13%). Telomerase activity was not detectable in 35 normal thyroid, 9 follicular adenoma, 7 nodular hyperplasia, 2 follicular carcinoma, and 2 medullary carcinoma. Lymphocytic thyroiditis was detected in 8 of 37 (22%) apparently normal thyroid tissues adjacent to papillary thyroid carcinoma and telomerase activity was present in 2 of these 8 specimens (25%). In conclusion, telomerase does not appear to be frequently activated in papillary thyroid carcinoma. The association of lymphocytic thyroiditis with papillary thyroid carcinoma may limit its clinical usefulness as a tumor marker. SN - 1050-7256 UR - https://www.unboundmedicine.com/medline/citation/10646661/Telomerase_activity_in_thyroid_malignancy_ L2 - https://www.liebertpub.com/doi/10.1089/thy.1999.9.1215?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -