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Identical clonality of sporadic gastrinomas at multiple sites.
Cancer Res. 2000 Jan 01; 60(1):60-3.CR

Abstract

Gastrinomas are neuroendocrine neoplasms that occur sporadically and in patients with multiple endocrine neoplasia type 1 (MEN1). In MEN1, multiple gastrinomas have been shown to arise by independent clonal events (Debelenko, et al., Cancer Res., 57: 2238-2243, 1997). The purpose of the present study was to analyze clonality in 20 sporadic gastrinomas from eight patients in whom the tumor was present in at least two separate sites. A combination of methods was used to assess clonality, including MEN1 gene mutation analysis, loss of heterozygosity analysis of the MEN1 locus, and analysis of X-chromosome inactivation at the human androgen receptor locus (human androgen receptor analysis). In three patients, a somantic MEN1 gene mutation was detected in the tumor. Identical mutations were found in other tumors at different sites within the same patients. Human androgen receptor analysis in three informative patients and loss of heterozygosity analysis in five patients revealed identical clonal patterns in the tumors from multiple sites in each patient. We conclude that sporadic gastrinomas at multiple sites are monoclonal and that MEN1 gene alterations in gastrinomas occur before the development of tumor metastases.

Authors+Show Affiliations

Digestive Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10646853

Citation

Goebel, S U., et al. "Identical Clonality of Sporadic Gastrinomas at Multiple Sites." Cancer Research, vol. 60, no. 1, 2000, pp. 60-3.
Goebel SU, Vortmeyer AO, Zhuang Z, et al. Identical clonality of sporadic gastrinomas at multiple sites. Cancer Res. 2000;60(1):60-3.
Goebel, S. U., Vortmeyer, A. O., Zhuang, Z., Serrano, J., Jensen, R. T., & Lubensky, I. A. (2000). Identical clonality of sporadic gastrinomas at multiple sites. Cancer Research, 60(1), 60-3.
Goebel SU, et al. Identical Clonality of Sporadic Gastrinomas at Multiple Sites. Cancer Res. 2000 Jan 1;60(1):60-3. PubMed PMID: 10646853.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identical clonality of sporadic gastrinomas at multiple sites. AU - Goebel,S U, AU - Vortmeyer,A O, AU - Zhuang,Z, AU - Serrano,J, AU - Jensen,R T, AU - Lubensky,I A, PY - 2000/1/26/pubmed PY - 2000/1/26/medline PY - 2000/1/26/entrez SP - 60 EP - 3 JF - Cancer research JO - Cancer Res VL - 60 IS - 1 N2 - Gastrinomas are neuroendocrine neoplasms that occur sporadically and in patients with multiple endocrine neoplasia type 1 (MEN1). In MEN1, multiple gastrinomas have been shown to arise by independent clonal events (Debelenko, et al., Cancer Res., 57: 2238-2243, 1997). The purpose of the present study was to analyze clonality in 20 sporadic gastrinomas from eight patients in whom the tumor was present in at least two separate sites. A combination of methods was used to assess clonality, including MEN1 gene mutation analysis, loss of heterozygosity analysis of the MEN1 locus, and analysis of X-chromosome inactivation at the human androgen receptor locus (human androgen receptor analysis). In three patients, a somantic MEN1 gene mutation was detected in the tumor. Identical mutations were found in other tumors at different sites within the same patients. Human androgen receptor analysis in three informative patients and loss of heterozygosity analysis in five patients revealed identical clonal patterns in the tumors from multiple sites in each patient. We conclude that sporadic gastrinomas at multiple sites are monoclonal and that MEN1 gene alterations in gastrinomas occur before the development of tumor metastases. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/10646853/Identical_clonality_of_sporadic_gastrinomas_at_multiple_sites_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=10646853 DB - PRIME DP - Unbound Medicine ER -